CONTENTS. Committees of the 4 rth International H.S.S.B.M. Scientific Meeting...4. Acknowledgements...5. Invitation Letter...7

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3 CONTENTS Committees of the 4 rth International H.S.S.B.M. Scientific Meeting...4 Acknowledgements...5 Invitation Letter...7 Scientific Programme...8 List of Speakers...10 Registration Fees...11 Social Events...12 General Information...13 Hotel Accomodation...15 Airplane Schedule

4 COMMITTEES of the 4 th International H.S.S.B.M. Scientific Meeting Seminar Presidents Skarantavos Grigorios Paschalis Eleftherios Executive Committee H.S.S.B.M. President Vice President Gen. Secretary Treasurer Members Karachalios Theofilos Kataxaki Evangelia Kosmidis Christos Lagoudakis Aristidis Kaldrimidis Filippos Karamitsiou Victoria Trovas Georgios 4 Presidents Scientific Committee Skarantavos Grigorios Paschalis Eleftherios Atsali Erato Kaldrimidis Filippos Karachalios Theofilos Karamitsiou Victoria Kataxaki Evangelia Katsibri Pelagia Kosmidis Christos Lagoudakis Aristidis Metania Eleftheria Stathopoulos Konstantinos Trovas Georgios

5 ACKNOWLEDGEMENTS of the 4 th International H.S.S.B.M. Scientific Meeting The Organizing Committee of the 4 rth International Scientific HSSBM Seminar wish to thank all Sponsors and Exhibitors listed below, for their support to the Scientific and Social programme of the Seminar. 5

ORGANIZED BY HSSBM Hellenic Society for the Study of Bone Metabolism 2 Thrakis St., 15124 Maroussi, Greece Tel./Fax: +30 210 6128606, E-mail: eemmo@otenet.gr Web site: www.eemmo.gr SEMINAR SECRETARIAT PCO-CONVIN S.

6 ORGANIZED BY HSSBM Hellenic Society for the Study of Bone Metabolism 2 Thrakis St., Maroussi, Greece Tel./Fax: , eemmo@otenet.gr Web site: SEMINAR SECRETARIAT PCO-CONVIN S.A. 29 Costa Varnali St., Chalandri, Greece Τel.: , Fax: congress@pco-convin.gr Web site: 6

7 INVITATION LETTER Dear colleagues, There is no doubt that there have been many changes in general theories of biology and pathology of the musculoskeletal system in the past few years. We now realize that the architectural properties of the bone are important factors in bone physiology, both in normal and diseased conditions. An abundance of information from the basic sciences is helping us in the search for treatment and understanding of metabolic diseases of the bone. This new accumulated knowledge of the basic sciences has opened new horizons, but has also generated new questions regarding the therapeutic methods that we follow in the management of bone disease. HSSBM has already organized three meetings on the topic of bone quality and its parameters. At these meetings, high level, in-depth analyses of the various theories have been undertaken. We have decided that, for the year 2009, the 4 th International Meeting to discuss the parameters of bone quality and strength will be organized on Mykonos on the 25 th - 27 th of September. Dr. Gregory Skarantaros and Dr. Eleftherios Pashalis will be responsible for the scientific programme of this Meeting - they have been similarly responsible for previous, highly successful Meetings. I therefore invite you to a challenging scientific Meeting on the magical island of Mykonos. I am sure that this will be a very inspiring Conference. I look forward to welcoming you to Mykonos. Your colleague, Dr Th. Karachalios, MD, DSc Associate Professor in Orthopaedics President of the H.S.S.B.M

8 SCIENTIFIC PROGRAMME 17:00-19:30 Registrations 20:00 Opening Ceremony & Welcome Reception Venue to be announced 08:30-16:00 Registrations 09:00-09:45 Finite element analysis for prediction of bone strength: assumptions and current results P. Zyssett, Austria 09:45-10:30 Potential future diagnostic techniques C. Kontoyannis, Greece 10:30-11:15 Cortical porosity: Bisphosphonates decrease it and this is good. PTH increases it and this is good/not detrimental. What is the explanation for this apparent discrepancy? D. Agnusdei, Italy 11:15-12:00 Placebo: Since nowadays vit D and Ca are given along with the placebo, what are the effects of these 2 supplements on bone? P. Roschger, Austria 12:00-12:45 Comprehensive approach of osteonecrosis K.N. Malizos, Greece 12:45-13:45 Light Lunch Friday, September Saturday, September :45-14:30 Biomechanics: If we want to stimulate in vivo conditions then why do we use any other test other than cyclic loading? Th. Karachalios, Greece 14:30-15:15 DXA vs pqct G. Skarantavos, Greece 8

9 15:15-16:00 Schnurri-3 Null Mice: A new target for therapies and does Bone Mass influence Bone Quality? J.G. Hofstaetter, Austria 21:00 Gala Dinner 08:30-15:00 Registrations 09:00-09:45 Are all antiresorptives the same E. Eriksen, Norway 09:45-10:30 Biological mechanism of SrR therapy P.J. Marie, France 10:30-11:15 Strontium and apatites P.G. Koutsoukos, Greece Venue to be announced 11:15-12:00 Hyper- and Hypoparathyroidism: Altered bone turnover in both, yet no fractures. Why? D.W. Dempster, USA 12:00-12:30 Light Lunch Sunday, September :30-13:15 Is collagen ageing important for bone quality? S.P. Robins, UK 13:15-14:00 Homocysteine: An all out attack on the osteoblast, while welcoming the osteoclast E. Paschalis, Austria 14:00-14:45 Is there anything to be learned from the dental and orthopaedic surgery fields? D. Tatakis, USA 14:45-15:30 Osteoporosis therapies & bone mineral density distribution: a comprehensive comparison P. Roschger, Austria 15:30-16:00 Conclusions - End of the Scientific Meeting Foyer «Dilos» Hall «Dilos» 9

10 10 LIST AGNUSDEI DONATO DEMPSTER W. DAVID ERIKSEN FINK ERIK HOFSTAETTER G. JOCHEN KARACHALIOS THEOFILOS KONTOYANNIS CHRISTOS KOUTSOUKOS G. PETROS MALIZOS N. KONSTANTINOS MARIE J. PIERRE PASCHALIS ELEFTHERIOS ROBINS P. SIMON ROSCHGER PAUL SKARANTAVOS GRIGORIOS TATAKIS N. DIMITRIOS ZYSSET PHILIPPE OF SPEAKERS MD, Associate Professor, Medical Fellow Osteoporosis Europe and Latin America, Florence, Italy Professor of Clinical Pathology Columbia University, New York, Director, Regional Bone Center Helen Hayes Hospital West Haverstraw, New York, USA Professor, Section Head, DMSc, Oslo University Hospital, Faculty Division Aker Sykehus, Oslo, Norway Dr., LBI of Osteology and Department of Orthopaedics, Medical University of Vienna, Austria MD, DSc, Associate Professor of Orthopaedics, Medical School of University of Thessalia, Orthopaedic Department, University General Hospital of Larissa, Greece Associate Professor, Department of Pharmacy, University of Patras, Greece Professor, Laboratory of Inorganic and Analytical Chemistry Department of Chemical Engineering University of Patras, Greece MD, PhD, Professor of Orthopaedics & Musculoskeletal Trauma Dean of Faculty of Medicine, University of Thessalia, Orthopaedic Department, University General Hospital of Larissa, Greece Dr., Director of Research at CNRS, INSERM UMR 606 & University Paris Diderot, Hôpital Lariboisière, France PhD, Senior Scientist, Ludwig Boltzmann Institut fuer Osteologie im Hanusch-Krankenhaus der WGKK und Unfallkrankenhaus Meidling der AUVA, Vienna, Austria Head, Matrix Biochemistry Group, Rowett Institute of Health and Nutrition, University of Aberdeen, United Kingdom Associate Professor, PhD, Senior Scientist, Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Vienna, Austria Rheumatologist Director, Metabolic Bone Unit, 1 st Department of Orthopaedic Surgery, University of Athens, School of Medicine, «Attikon» University General Hospital, Athens, Greece DDS, PhD, Diplomate, American Board of Periodontology, Professor and Director of Postdoctoral Program, Division of Periodontology, College of Dentistry, The Ohio State University, Columbus, USA Professor, PhD, Institute of Lightweight Design and Structural Biomechanics, Vienna Institute of Technology, Vienna, Austria

11 REGISTRATION FEES Fees until 30/07/2009 from 31/07/2009 & on site H.S.S.B.M. Members 310,00 340,00 Non-members 350,00 430,00 Inters 200,00 220,00 Accompanying persons 80,00 80,00 Registration entitles the participants to: Attendance of the scientific programme A folder with all printed material The final programme Certificate of attendance 2 coffee breaks 2 light lunches Participation in the Opening Ceremony and Welcome Reception Participation in the Gala Dinner Registration fees for accompanying persons include: Entrance to the seminar area Participation in the Opening Ceremony and Welcoming Reception Participation in the Gala Dinner CANCELLATION POLICY - NAME CHANGE For cancellations submitted in written to the seminar secretariat until July 30 th, 2009, 50,00 will be withheld as expenses for secretariat support. For cancellations submitted in written to the seminar secretariat between July 31 st and August 10 th, 2009, 50% of the total registration cost will be withheld as cancellation fee. No return of funds is possible for cancellations submitted after August 11 th, For name changes submitted in written to the seminar secretariat until July 30 th, there will be no extra charge For name changes submitted in written to the seminar secretariat from July 31 st until August 20 th, 30,00 will be withheld as expenses for secretariat support. Name changes are not possible after September 1 st

12 SOCIAL EVENTS Friday, September Opening Ceremony - Welcome Reception Venue to be announced Saturday, September Gala Dinner Venue to be announced Transportation by bus Private buses have been hired for the transportation of the participants and accompanying persons from their hotel to the place where the Opening Ceremony - Welcoming Reception and Gala Dinner will be held. The Seminar Secretariat will announce times of departure and return at the reception desk of each hotel. Note: Due to limited availability, confirmation of participation in the Social events is mandatory. Please confirm your participation, as well as that of your escort(s), to the Seminar secretariat, upon reception of the printed material of the seminar. Numbered invitations (delivered by the seminar secretariat, upon confirmation of participation) will be required for the entrance of the participants and escorting parties in the areas where social events are being held. 12

13 GENERAL INFORMATION Location & Seminar Venue Royal Myconian Hotel Elia Beach, Myconos Tel.: Fax: Seminar Dates Friday September Saturday September Sunday September Working Hours of the Seminar Secretariat During the seminar the secretariat will remain open as follows: Friday September :00-19:30 Saturday September :30-16:00 Sunday September :30-15:00 Official Language English will be the official language of the Seminar. Commercial Exhibition During the course of the seminar there will be a commercial exhibition of Pharmaceutical Companies in the foyer of the seminar hall. Contact Address Before and After the Completion of the Seminar PCO CONVIN S.A. 29 K. Varnali Str Chalandri, Athens Tel.: Fax: congress@pco-convin.gr Web site: 13

14 GENERAL INFORMATION Final Programme The secretariat will provide the final program of the seminar to the participants, upon presentation of confirmation of pre-registration. The program will also appear at the following websites: Projection - Presentations Lectures can be projected during the course of the seminar through a computer data projector and overhead projector. Speakers are requested to deliver their work in electronic form to the Presentations Reception Desk, at least 1 hour before each event. Transportation by shuttle busses Shuttle busses will be used for the transportation of all participants staying at Myconian Ambassador and Myconos Grand to the Royal Myconian (seminar venue) and back. The Seminar Secretariat will announce departure and return times at each hotel reception. 14

15 HOTEL ACCOMODATION In order to assure the accommodation of all participants to the 4 th International Scientific Meeting H.S.S.B.M., PCO CONVIN S.A. has pre-reserved rooms in the Hotel where the seminar will be held and nearby hotels, as follows: Hotel Location Rating Double for Double Triple single use Royal Myconian Elia Beach De Luxe 205,00 220,00 270,00 & Imperial Hotel Myconian Platis Gialos De Luxe 205,00 220,00 270,00 Ambassador Boutique Hotel Mykonos Grand Ayios Yiannis De Luxe 205,00 220,00 270,00 Hotel & Resort Notes: All above mentioned prices are per room, per night and include breakfast and taxes. A 2 day stay is mandatory. Extra charge for half board: 35,00 The above price is per person, per meal and does not include beverages. Cancellation Policy For cancellation of reservations, submitted in written to the seminar secretariat up to July 31 st, no cancellation charges apply. For cancellation of reservations, submitted in written to the seminar secretariat between August 1 st and August 20 th, 50% of the total cost will be withheld as cancellation fees. No return of funds is possible for cancellations submitted in written to the seminar secretariat after August 21 st,

16 AIRPLANE SCHEDULE Catering to the need of all participants to the 4 th International Scientific Meeting H.S.S.B.M., PCO CONVIN S.A. has secured seats on several flights of different air companies, as listed below: OLYMPIC AIRWAYS Flights from / to Athens: From To Flight Nr. Date Departure Arrival Time Time Athens Myconos OA /09/09 12:35 13:15 From To Flight Nr. Date Departure Arrival Time Time Myconos Athens ΟΑ /09/09 19:45 20:25 Ticket cost:

AEGEAN AIRLINES Flights from / to Athens: From To Flight Nr. Date Departure Arrival Date Time Athens Myconos A3 374 25/09/09 12:00 12:35 Athens Myconos A3 378 25/09/09 18:00 18:35 From To Flight Nr.

17 AEGEAN AIRLINES Flights from / to Athens: From To Flight Nr. Date Departure Arrival Date Time Athens Myconos A /09/09 12:00 12:35 Athens Myconos A /09/09 18:00 18:35 From To Flight Nr. Date Departure Arrival Date Time Myconos Athens A /09/09 13:10 13:45 Myconos Athens A /09/09 19:10 19:45 Ticket cost: 300 Above prices include: * fuel surcharge * airport taxes * transfers from and to Myconos airport. Notes: 1. In case you choose to use a combination of Olympic Airlines and Aegean flights the ticket cost will be In case of any modification of the fuel surcharge and / or the airport taxes, ticket cost will be relatively modified. 17

3rd Bone Final Pr En pr :08 ÂÏ 1

3rd Bone Final Pr En pr :08 ÂÏ 1 3rd Bone Final Pr En pr 19-9-2007 18:08 ÂÏ 1 3rd Bone Final Pr En pr 19-9-2007 18:08 ÂÏ 2 3rd Bone Final Pr En pr 19-9-2007 18:08 ÂÏ 3 CONTENTS Acknowledgements...4 Invitation Letter...5 Committees of