August 2016! NEWSLETTER!

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1 August 2016! NEWSLETTER!

2 Highlights this Month 159 pa<ents recruited (42 this month) ARUK offer 274k to support BOSS 14 th Nov 2016 Collaborator Mee<ng USA to mirror the BOSS Study Airedale coming on-board Many congratula<ons on the early success of the BOSS Study such collabora<ve endeavors are clearly the way forward for our specialty. Canada is watching with interest. Mar$n Gargan Chair of Orthopaedics SickKids, Toronto

3 Monthly Case Confirma$on We ask every site to click a simple link each month to confirm case uploads this is the only way we can ensure people are looking for cases. 111 sites confirmed case uploads were complete for July. Barnet and Chase Barnsley Hospital Barts Basildon Basingstoke Bedford Betsi Cadwaladr Birmingham Blackpool Bolton Borders General Brighton and Sussex Bristol Buckinghamshire Calderdale Cardiff Chelsea Chester Colchester Coventry Cwm Taf Derby Doncaster Dorset County Dudley Dumfries East & North Herts East Kent East Lancashire East Sussex Edinburgh Epsom Forth Valley Glasgow Great Western Guys Hairmyres Harrogate Heart Of England Hinchingbrooke Homerton Hull Imperial Inverclyde Ipswich James Paget KeYering Kings College Lancashire Leicester Lincolnshire Liverpool Leeds Maidstone Medway Mid Cheshire Mid Essex Mid Yorkshire Morecambe Bay Newcastle Norfolk and Norwich North Cumbria North Midlands North West London Northampton Northern Devon No[ngham Oxford Pennine (Nth Manc) Peterborough Plymouth Poole Portsmouth Raigmore Robert Jones Rotherham Royal Aberdeen Royal Alexandria Royal Berkshire Royal Devon Royal Free Royal Na<onal Ortho Royal Surrey Royal United Bath Salisbury Scarborough Sheffield Shrewsbury South Devon South Manchester South Tees Southampton Southport St Georges St Helens Stockport Swansea Tameside The Princess UCL Warrington West Middlesex West Suffolk Wexham Park Whipps Cross Whi[ngton Wirral Worcestershire Worthing Wrigh<ngton, Wye Valley We are wai$ng on a few sites: Aneurin Bevan Barking Bradford Cambridge Chesterfield Durham Fife Gloucestershire Great Ormond Street Hillingdon Lewisham Luton Manchester Milton Keynes Monklands Northumbria Nth Lincolnshire and Goole Pennine Acute (Oldham) Royal Cornwall Sandwell South London Healthcare Sunderland Taunton Tayside Wolverhampton Crosshouse West Herts Western Isles Winchester Wishaw York Click the link now to confirm uploads for August

4 Recruitment? BOSS is now one of the best recrui<ng studies in the NHS. We have 159 recruits in 4 months. Which Pa$ents? Slipped Epiphysis - All new cases of disease. Enter them post-op. Perthes Disease All new cases presen<ng to providers of defini<ve care (i.e. may be diagnosed 6 months ago but taken some <me to be referred from emergency dept, GP, colleagues etc). August Top 5 Coventry Cwm Taf Durham Guys Worcester Who has recruited? Amazingly 59 sites have recruited so far Barts Peterborough Basildon Plymouth Birmingham Portsmouth Bristol Robert Jones Buckinghamshire Royal Alexandria Cambridge Royal Cornwall Cardiff Royal Free Chelsea Royal Na<onal Orth Colchester Royal Berks Coventry Royal Surrey Crosshouse Southport Cwm Taf Stoke Dudley Stockport Durham Southampton East Kent Taunton East Sussex United Lincoln East Lancs Warrington Epsom West Middlesex Great Ormond St Wexham Park Guys Whi[ngton Hull Worcester Kings Worthing Lancashire Wexham Park Lewisham Milton Keynes Liverpool Norwich No[ngham Manchester Maidstone & Tunbridge Milton Keynes Morecambe Bay Newcastle North Midlands No[ngham Oxford One of the fastest recruiting studies in the UK

5 Addi$onal Funding? ARUK have awarded the BOSS Collabora<ve 274k in associa<on with computer scien<st Prof Tim Cootes (University of Manchester). This funding will use the radiographs the BOSS Study to automate the detec<on of radiographic outcomes, and to try to predict late disease payerns from early radiographic features. Unfortunately a grant from Ac<on Medical Research about the mechanics of SCFE, in associa<on with Prof Mike Fagan (University of Hull) has been turned down. Across the Pond We have had contact from by the USA and Canada expressing their keenness to mirror the BOSS Study. We are working with the through the IMPACCT network to develop interna<onal collabora<ons. BOSS Study Day The BOSS Study has amazing engagement, and we need to harness everyone s enthusiasm to plan the next study. NIHR representa<ve have expressed delight with BOSS recruitment, and there is a willingness to support and enable the group to be a worldleading research collabora<ve. Monday 14 th Nov The Studio, Birmingham A mee<ng is planned next to New Street Sta<on in Birmingham (10am start) in November to plan the next steps for the BOSS Collabora<ve. We have asked the RCS Eng for CPD points, and have a budget to support travel expenses etc. Register via the link sent with this newsleyer. One of the fastest recruiting studies in the UK

6 Requests from the study manager Case Confirma$on. Please confirm case uploads by clicking the link on the , rather than ing us it is far simpler to manage (and takes about 10 seconds to do). Pa$ent ID. Just to remind you that the study generates a unique number, i.e this is the number that you should include on consent forms and ques<onnaires. Please do not include any iden<fiable details (i.e. name/ DOB). Make sure you keep a note of this study number along with the pa<ent name, DOB etc in your hospital. Sending Radiographs. We would prefer radiographs via the IEP link (beyer image quality). We will send a formal document to research teams in the next week. PROCEDURE FOR PACS TEAMS: q Iden<fy the x-ray study to be transferred. q Duplicate the images and anonymise the pa<ent details as follows: Replace the Name, NHS Number, Hospital number and any other PID with the BOSS Study number. Replace the date of birth with the date 1 st January Ensure that there are no other items of data on the study that could iden$fy the pa$ent. Your Informa<on Governance Policy will provide further details. q Login to IEP, create a new transfer. q Enter the des<na<on as Alder Hey Children s NHS Founda5on Trust. q Enter the demographics for the pa<ent (BOSS Study number as surname, forename, hospital number and NHS number, and the date of birth as 01/01/2001). q Select the study from the Studies list. q Select the Des<na<on Node RBS_Research and the Priority Overnight Download. Sending us consent forms For those taking part in the consented element of the study, please ensure that consent forms and pa<ent materials are sent by post or fax to the CTU not . Dr Emma Cwiklinski BOSS Study Coordinator Any questions contact BOSS@liverpool.ac.uk

7 Who are the BOSS Collabora$ve?

8 Who are the lead inves$gators at sites (1 of 2)? HOSPITAL LEAD+CONSULTANT Abertawe Bro Morgannwg University Health Board (Swansea, Wales) Paul Williams Alder Hey Children's NHS Foundation Trust Colin Bruce Aneurin Bevan Health Board (Wales) Mr Sujit Kadambande Barking, Havering and Redbridge University Hospitals NHS Trust Krishna Vemulapalli Barnet and Chase Farm Hospitals NHS Trust Bob Chatterjee Barnsley Hospital NHS Foundation Trust Nick Nicolaou Barts & The London Manoj Ramachandran Basildon and Thurrock University Hospitals NHS Foundation Trust Madhu Tiruveedhula Bedford Hospital NHS Trust Phillip Edge Betsi Cadwaladr University Health Board (Wales) * Mr Koldo Azurza Birmingham Children's Hospital NHS Foundation Trust Ed Bache Blackpool Teaching Hospitals NHS Foundation Trust Amit Shah Bolton NHS Foundation Trust Mr Majid Bradford Teaching Hospitals NHS Foundation Trust David Shaw Brighton and Sussex University Hospitals NHS Trust Naidu Maripuri Buckinghamshire Healthcare NHS Trust Jo Hicks Calderdale and Huddersfield NHS Foundation Trust * Mr Nitish Gogi Cambridge University Hospitals NHS Foundation Trust Kuldeep Stohr Cardiff and Vale University Local Health Board Clare Carpenter Central Manchester University (Manchester Children's) Sattar Alshryda Chelsea and Westminster Hospital NHS Foundation Trust Stuart Evans Chesterfield Royal Hospital NHS Foundation Trust John Cashman City Hospitals Sunderland NHS Foundation Trust Mr G De Kiewiet Colchester Hospital University NHS Foundation Trust V Shiv Shanker Countess Of Chester Hospital NHS Foundation Trust Pete Kenyon County Durham and Darlington NHS Foundation Trust Jonathan Page Croydon Health Services NHS Trust Miss Karen Daly Cwm Taf Health Board Judy Murray Derby Hospitals NHS Foundation Trust Mohan Utukuri Doncaster and Bassetlaw Hospitals NHS Foundation Trust Robert Kuchaski Dorset County Hospital NHS Foundation Trust Nicholas Savva East and North Hertfordshire NHS Trust Nick de Roeck East Kent Hospitals University NHS Foundation Trust (QEQMH) Mark Cornell East Lancashire Hospitals NHS Trust Robin Paton East Sussex Healthcare NHS Trust Adrian Butler-Manual Epsom and St Helier University Hospitals NHS Trust Mark Churchill Frimley Park Hospital NHS Foundation Trust Azal Jalgaonkar Gloucestershire Hospitals NHS Foundation Trust Mr R Brown Great Ormond Street Hospital for Children NHS Foundation Trust Andreas Roposch Great Western Hospitals NHS Foundation Trust Sarah Irby Guy's and St Thomas' NHS Foundation Trust Mr Fabian Norman-Taylo Hampshire Hospitals NHS (Baisingstoke) Nigel Rossiter Hampshire Hospitals NHS (Winchester) Iain MacLeod Harrogate and District NHS Foundation Trust * Mr David Lavalette Heart Of England NHS Foundation Trust Rozalia Dimitriou Hillingdon Hospitals NHS Foundation Trust * Sanjay Kumar Hinchingbrooke Health Care NHS Trust Mr Arpit Patel Homerton University Hospital NHS Foundation Trust Toby Baring Hull and East Yorkshire Sally Hobson Imperial College Healthcare NHS Trust * Raj Bhattacharya Ipswich Hospital NHS Trust Graeme Carlile James Paget University Hospitals NHS Foundation Trust * Anish Snaghrajka Kettering General Hospital NHS Foundation Trust S Shyamsunder King's College Hospital NHS Foundation Trust Om Lahoti Lancashire Teaching Hospitals NHS Foundation Trust Tony McEvoy Leeds General Infirmary Colin Holton Lewisham and Greenwich NHS Trust * Mohammed Abdus-Same Luton and Dunstable Hospital NHS Foundation Trust Yega kalairajah Maidstone and Tunbridge Wells NHS Trust Jo Dartnell Medway NHS Foundation Trust * Prof Bijay Singh Mid Cheshire Hospitals NHS Foundation Trust David Machin Mid Essex Hospital Services NHS Trust Jeremy Tuite Mid Yorkshire Hospitals NHS Trust Nirmal Tulwa Milton Keynes Hospital NHS Foundation Trust Julian Flynn Norfolk and Norwich University Hospitals NHS Foundation Trust Anish Sanghrajka North Cumbria University Hospitals NHS Trust Carol Brignall North West London Hospitals NHS Trust (also includes Ealing above) Ian Holloway Northampton General Hospital NHS Trust Mr R Natarajan Northern Devon Healthcare NHS Trust Nick Treble Northern Lincolnshire and Goole Hospitals NHS Foundation Trust F R Howell Northumbria Healthcare NHS Foundation Trust John Leitch Nottingham University Hospitals NHS Trust Kathryn Price Oxford University Hospitals NHS Trust Rachel Buckingham Pennine Acute Hospitals NHS Trust (North Manchester) Edward Yates

9 Who are the lead inves$gators at sites (2 of 2)? HOSPITAL LEAD+CONSULTANT Pennine Acute Hospitals NHS Trust (Oldham) Mr Ardeshir Bonshahi Peterborough and Stamford Hospitals NHS Foundation Trust Mr P Mitchell Plymouth Hospitals NHS Trust Ben Holroyd Poole Hospital NHS Foundation Trust Alexander Aarvold Queen Alexander Hospital, Porstsmouth Robert Richards Queen Elixabeth Hospital, Woolwich - part of University Hospital LewishSunil Bajaj Robert Jones and Agnes Hunt Orthopaedic and District Hospital NHS T Robert Freeman Royal Berkshire NHS Foundation Trust Nev Davies Royal Cornwall Hospitals NHS Trust Mr Russell Hawkins Royal Devon and Exeter NHS Foundation Trust Peter Cox Royal Free London NHS Foundation Trust Olivia Malaga Shaw Royal National Orthopaedic Hospital NHS Trust Deborah Eastwood Royal Surrey County NHS Foundation Trust Chris Coates Royal United Hospital Bath NHS Trust Andy McBride Royal West Sussex AND Worthing And Southlands Hospitals Nhs Trust Adam Ajis Salisbury NHS Foundation Trust Phil Pettit Sandwell and West Birmingham Hospitals NHS Trust Siten Roy Scarborough and North East Yorkshire Health Care NHS Trust Suraj Joshy Sheffield Children's NHS Foundation Trust Sanjeev Madan Shrewsbury and Telford Hospital NHS Trust* Jae Rhee South Devon Healthcare NHS Foundation Trust Guy Wansbrough South Tees Hospitals NHS Foundation Trust Hopcroft Richard Southport and Ormskirk Hospital NHS Trust Marcus Cope St George's Healthcare NHS Trust Ms Karen Daly St Helens and Knowsley Hospitals NHS Trust Stephen Lipscombe Stockport NHS Foundation Trust Barnes Morgan Tameside Hospital NHS Foundation Trust Wiqqas Jamil Taunton and Somerset NHS Foundation Trust Andrew J Kelly The Dudley Group NHS Foundation Trust Veronique Spiteri The Newcastle Upon Tyne Hospitals NHS Foundation Trust Philip Henman The Princess Alexandra Hospital NHS Trust Alex Amini The Rotherham NHS Foundation Trust Stephen Giles The Royal Wolverhampton NHS Trust Ram Vadivelu The Whittington Hospital NHS Trust Adrian O'Gorman United Lincolnshire Hospitals NHS Trust Tom Southorn University College London Hospitals NHS Foundation Trust Mr Michael J Oddy University Hospital Of South Manchester NHS Foundation Trust Nasser Kurdy University Hospital Southampton NHS Foundation Trust Alex Aarvold University Hospitals Bristol NHS Foundation Trust Fergal Monsell University Hospitals Coventry and Warwickshire NHS Trust Stephen Cooke University Hospitals Of Leicester NHS Trust Mr Alwyn Abraham University Hospitals Of Morecambe Bay NHS Foundation Trust Paul Marshall University Hospitals of the North Midlands Belen Carsi Warrington and Halton Hospitals NHS Foundation Trust David Atkinson West Hertfordshire Hospitals NHS Trust* Krisztian Deierl West Middlesex University Hospital NHS Trust* Hilal Fareed West Suffolk NHS Foundation Trust Miss S Deakin Wexham Park (Frimley Health NHS) Jacob Thampy Whipps Cross University Hospital Kes Sri-Ram Wirral University Teaching Hospital NHS Foundation Trust Gillian Jackson Worcestershire Acute Hospitals NHS Trust Charlie Docker Wrightington, Wigan and Leigh NHS Foundation Trust Henry Wynn Jones Wye Valley NHS Trust Iain Bissell York Teaching Hospital NHS Foundation Trust Ken Mannan Who isn t in the BOSS group? Airedale NHS Trust (although they are now trying to join) North Middlesex Hospital (no contact at all established even through the medical director) Fife (threatening to leave owing to problems with administra<on) The biggest study on the NIHR portfolio almost everyone treating orthopaedic diseases of childhood

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