Mixing Your Alpha-1 Therapy Aralast NP
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- Daniella Miller
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1 Mixing Your Alpha-1 Therapy Aralast NP Administration Note: It is important to establish IV access prior to preparing your Aralast NP. Refer to the patient education tool Performing Venipuncture for further instruction. 1. Refer to your Coram Patient Resource Guide and medication label for handling and storage of medication. 2. Clean your work area. 3. Wash your hands: a. Use antibacterial soap and water, rubbing your hands for at least 20 seconds. Remove any dirt from under your nails. Dry your hands with a paper towel or clean hand towel. b. If no soap and water is available, use an alcoholbased hand sanitizer. 4. Gather supplies: a. Aralast NP Medication Kit(s) Medication vial Diluent (sterile water) Baxject II transfer device b. Aralast NP Supply Kit 60 ml luer lock syringe Empty IV fluid bag (500 ml) Clave bag access spike Administration tubing (gravity or rate flow) c. Alcohol swabs 5. Inspect vial(s) and label for the following: a. Correct name b. Expiration date c. Clarity of the solution (it should be clear and colorless) d. An intact protective cap Call your pharmacist if you have problems with the bag or label Coram LLC COR
2 6. Reconstitute the Aralast NP using the Baxject II transfer device: a. Prepare the vials. 1. Take the protective caps off of the Aralast NP and diluent. 2. Clean the top of each vial with an alcohol swab. b. Connect the transfer device: 1. Open the seal of the Baxject II transfer device (leave the device in the package). Do not to touch the spike of the device (Fig A). FIG. A 2. Connect the clear side of the transfer device to the diluent until the spike pierces the vial stopper. Press firmly enough to get a tight seal with the transfer device and diluent vial (Fig B). FIG. B 3. Grip the transfer device packaging at the edge and lift off (Fig C). Once the packaging is removed, a colored spike is exposed. Do not touch the spike or remove the blue cap from the device (Fig C). FIG. C 2
3 4. Turn the transfer device over and connect the purple side to the Aralast NP vial (Fig D). FIG. D a. Press down until the purple spike pierces the vial stopper. The diluent will automatically flow to the Aralast NP vial by gravity. b. Once all the diluent goes into the Aralast NP vial, GENTLY swirl the vial with the device still attached until all of the Aralast NP is dissolved. Do not shake the vial, as this will cause foaming. c. Reconstitution requires no more than five minutes for a 0.5 gram vial and no more than 10 minutes for a 1.0 gram vial. c. Withdraw the Aralast NP from the vial (be sure to leave it on a hard, flat surface). 1. Remove the blue cap from the side of the transfer device. Attach a 60 ml luer lock syringe by twisting clockwise. Do not draw or inject air into the syringe (Fig E). FIG. E 1 2 3
4 2. Turn the transfer device over so the Aralast NP vial is on top. Slowly pull back on the syringe plunger to withdraw the Aralast NP medication into the syringe. There is a filter inside the Baxject II transfer device, so filtering automatically occurs during this step (Fig F). FIG. F a. Withdraw all of the reconstituted medication into the syringe. b. Before disconnecting the syringe from the Baxject II transfer device, you will need to add the clave access spike to the empty bag (see step 7). It is recommended that you mix all of the Aralast NP vials using the Baxject II transfer device before pulling any reconstituted medication into the syringe. You can use the same syringe to remove the medication from several vials, as long as the syringe and plunger are not contaminated when the medication is drawn into the syringe. Medication must be administered within three hours of reconstitution. 4
5 7. Add Aralast NP to the empty bag. Empty bag Clave access spike 60 ml luer lock syringe a. Spike the empty bag with the clave access spike. b. Clean the end of the clave access spike with an alcohol swab (scrub for a minimum of 15 seconds). c. Remove the syringe with the Aralast NP solution from the transfer device and attach to the clave access spike. d. Slowly inject the medication into the IV bag. You may need to repeat this step several times, until all the medication ordered is added to the bag. e. Open the administration tubing and close the clamp. Remove the administration set from the package and close the roller clamp. f. Invert the IV bag with the medication and carefully remove the clave access. The bag must be inverted or the medication will leak out. g. Remove the cover from the spike of the administration tubing and insert it into the IV bag through the same site where the clave access spike was attached. Twist it into the bag until it is securely in place. The bag is now spiked and ready for administration. 8. Prime the tubing. a. Hang the IV medication bag on the IV pole (make sure the roller clamp is closed). b. Squeeze the drip chamber and release until it is half full. c. Slowly open the roller clamp and allow the medication to fill the tubing. Close the roller clamp when the medication reaches the end of the tubing. 1. If using a rate flow regulator, turn the rate flow device to open when priming the tubing. 2. Turn the device to off/close when the tubing is primed. 5
6 9. Flush the catheter and connect the tubing. a. Open the clamp on the catheter. b. Scrub the injection cap with an alcohol swab for a minimum of 15 seconds. Allow to dry. c. Flush the catheter with saline as directed by your clinician (make sure the clamp is open). d. Remove the cap from the end of the tubing. Do not touch the end of the tubing. e. Attach the tubing to the catheter injection cap by twisting clockwise until it is secure. 10. Start the infusion. a. Slowly open the roller clamp on the tubing. b. Adjust the rate as directed by your clinician. If fusing a rate flow regulator, turn the dial to the rate of your infusion as directed by your clinician. You should begin to see drops in the drip chamber to indicate the medication is infusing. 11. End the infusion. a. Close the clamp on the tubing. b. Disconnect the tubing from the injection cap. Discard as directed by your clinician. c. As directed by your clinician, flush the catheter with saline, remove the peripheral IV, or both. Steps to reconstitution of Aralast NP using the Baxject II transfer device: FIG. A FIG. B FIG. C FIG. D FIG. E FIG. F 1 2 6
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