Motor neurone disease in England 1996 to A geographical profile of mortality.

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2 Motor neurone disease in England 1996 to A geographical profile of mortality. Authors: Michael Goldacre, David Yeates, Leicester Gill, Myfanwy Griffith, Henry McGuinness, Daniel Meddings Published by: Unit of Health-Care Epidemiology, Oxford University, and South East England Public Health Observatory, 2005 This document provides a geographical profile of mortality from motor neurone disease in England. The geographical areas covered are the standard local authority areas of England. The period covered is January to December The data are analysed from mortality files supplied to the Public Health Observatories by the Office for National Statistics. This analysis includes mortality data about males and females of all ages. The maps, charts and tables show both-sexes-combined and sex-specific results, including standardised mortality ratios (SMRs). The first set provides the data for males and females combined, the second for males, and the third for females. Within each set, the data in the map are shown as quintiles of local authorities, with the one-fifth of local authorities with the lowest SMRs shown in the lightest colour and the one-fifth of local authorities with the highest SMRs shown in the darkest colour. The error-bar chart provides a plot of the values of the SMR for each local authority area. Each vertical line represents one local authority area. It shows the point estimate for the SMR for the area with its 95% confidence. At a glance, the error-bar charts show the spread of SMRs across England and the extent to which variation across the country is statistically significant.

3 The scatter-plot shows the SMR for each local authority area plotted against the local authorities score for the Index of Multiple Deprivation (IMD 2004). Within each set, the first table shows the individual values of SMRs for each local authority, with the local authorities ranked in alphabetical order. For each local authority, the information in the table provides data about mortality showing the observed number of people who died (Obs.); the expected number (Exp.), obtained by applying national age-sex-specific rates to the age-sex distribution of the local authority population; and the SMR, calculated by indirect standardisation, with the 95% lower and upper confidence limits for the rate. The first part of the first table shows SMRs for the disease as the underlying cause of death. The second part shows SMRs for the disease as any mention. The second table shows the local authority areas ranked according to the value of the SMR (ranked from lowest to highest ratio) for the disease as the underlying cause. The third table shows the local authority areas ranked according to the value of the SMR (ranked from lowest to highest ratio) for mentions. Some technical notes: Dataset used: UHCE-built file from SEPHO, template 6 Diagnosis codes used: ICD ; ICD10 G12.2 Diagnosis position: underlying cause; and al mentions Period covered: deaths from to Age/sex restriction: all ages, both sexes Place of residence at time of death: England

4 We are very grateful for technical and clerical support from Susan Flynn and for statistical advice from Valerie Seagroatt. David Yeates, Leicester Gill, Myfanwy Griffith, Susan Flynn and Valerie Seagroatt are funded by the NHS National Centre for Research Capacity Development. Henry McGuinness and Daniel Meddings are funded by the South East England Public Health Observatory. Copyright UHCE Oxford University and South East England Public Health Observatory. The maps are based on data provided through EDINA UKBORDERS with the support of the ESRC and JISC and use boundary material which is copyright of the Crown. Source: 2001 Census Output Area Boundaries. Crown copyright Crown copyright material is reproduced with the permission of the Controller of HMSO.

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7 Motor neurone disease : average IMD score plotted against the SMR (underlying cause) for each local authority, Males y = x R 2 = Average IMD 2004 score SMR per population

8 Motor neurone disease :SMR (underlying cause) for each local authority, Males 450 SMR per 100,000 with 95% confidence s local authorities

9 Label Mortality to 2004 IMD 2004: Average Score Underlying cause Motor neurone disease, all ages, Males Mentions StHA GOR Obs. Exp. SMR Obs. Exp. SMR Ratio mentions to underlyin g cause N/A ALL ENGLAND UB Adur 17.0 Q19 J UB Allerdale 22.9 Q13 B UB Alnwick 16.1 Q09 A UB Amber Valley 18.9 Q24 E UC Arun 15.6 Q19 J UB Ashfield 27.8 Q24 E UB Ashford 13.4 Q18 J UB Aylesbury Vale 8.3 Q16 J UB Babergh 11.3 Q01 G AB Barking and Dagenham 31.3 Q06 H AC Barnet 16.1 Q05 H CC Barnsley 33.0 Q23 D UC Barrow-In-Furness 33.0 Q13 B UB Basildon 20.7 Q03 G UB Basingstoke and Deane 8.8 Q17 J UC Bassetlaw 25.7 Q24 E HA Bath and North East Somerset UA 12.2 Q20 K UD Bedford 17.5 Q02 G UC Berwick-upon-Tweed 21.2 Q09 A AD Bexley 15.0 Q07 H CN Birmingham 37.6 Q27 F UB Blaby 8.7 Q25 E EX Blackburn with Darwen UA 32.3 Q13 B EY Blackpool UA 33.9 Q13 B UD Blyth Valley 26.1 Q09 A UC Bolsover 30.5 Q24 E BL Bolton 29.4 Q14 B UB Boston 21.9 Q24 E HN Bournemouth UA 23.7 Q22 K MA Bracknell Forest UA 8.6 Q16 J CX Bradford 32.9 Q12 D UC Braintree 13.2 Q03 G

10 Label Mortality to 2004 IMD 2004: Average Score Underlying cause Motor neurone disease, all ages, Males Mentions StHA GOR Obs. Exp. SMR Obs. Exp. SMR Ratio mentions to underlyin g cause N/A ALL ENGLAND UB Breckland 14.5 Q01 G AE Brent 26.0 Q04 H UD Brentwood 8.9 Q03 G UB Bridgnorth 12.3 Q26 F ML Brighton and Hove UA 25.7 Q19 J HB Bristol, City of UA 27.7 Q20 K UC Broadland 9.6 Q01 G AF Bromley 13.2 Q07 H UB Bromsgrove 10.1 Q28 F UB Broxbourne 14.7 Q02 G UD Broxtowe 16.0 Q24 E UD Burnley 31.8 Q13 B BM Bury 23.5 Q14 B CY Calderdale 25.4 Q12 D UB Cambridge 14.6 Q01 G AG Camden 34.7 Q05 H UB Cannock Chase 20.3 Q26 F UC Canterbury 16.2 Q18 J UB Caradon 18.4 Q21 K UD Carlisle 22.2 Q13 B UC Carrick 19.2 Q21 K UE Castle Morpeth 15.8 Q09 A UC Charnwood 12.1 Q25 E UF Chelmsford 8.6 Q03 G UB Cheltenham 14.4 Q20 K UB Cherwell 11.2 Q16 J UB Chester 17.0 Q15 B UD Chesterfield 27.1 Q24 E UB Chester-Le-Street 21.4 Q10 A UD Chichester 10.7 Q19 J UC Chiltern 6.2 Q16 J UE Chorley 17.2 Q13 B

11 Label Mortality to 2004 IMD 2004: Average Score Underlying cause Motor neurone disease, all ages, Males Mentions StHA GOR Obs. Exp. SMR Obs. Exp. SMR Ratio mentions to underlyin g cause N/A ALL ENGLAND UC Christchurch 12.6 Q22 K UG Colchester 14.6 Q03 G UC Congleton 9.5 Q15 B UE Copeland 25.7 Q13 B UB Corby 27.1 Q25 E UC Cotswold 8.8 Q20 K CQ Coventry 28.2 Q28 F UB Craven 11.9 Q11 D UE Crawley 14.8 Q19 J UD Crewe and Nantwich 17.1 Q15 B AH Croydon 19.9 Q08 H UC Dacorum 9.5 Q02 G EH Darlington UA 24.6 Q10 A UD Dartford 17.2 Q18 J UC Daventry 10.2 Q25 E FK Derby UA 27.7 Q24 E UF Derbyshire Dales 12.5 Q24 E UD Derwentside 28.2 Q10 A CE Doncaster 31.5 Q23 D UE Dover 18.7 Q18 J CR Dudley 22.1 Q27 F UE Durham 18.5 Q10 A AJ Ealing 23.4 Q04 H UF Easington 41.8 Q10 A UC East Cambridgeshire 10.6 Q01 G UB East Devon 12.7 Q21 K UD East Dorset 8.2 Q22 K UC East Hampshire 8.1 Q17 J UD East Hertfordshire 6.3 Q02 G UC East Lindsey 24.6 Q24 E UD East Northamptonshire 11.8 Q25 E FB East Riding of Yorkshire UA 15.3 Q11 D

12 Label Mortality to 2004 IMD 2004: Average Score Underlying cause Motor neurone disease, all ages, Males Mentions StHA GOR Obs. Exp. SMR Obs. Exp. SMR Ratio mentions to underlyin g cause N/A ALL ENGLAND UC East Staffordshire 18.5 Q26 F UC Eastbourne 21.5 Q19 J UD Eastleigh 8.9 Q17 J UE Ellesmere Port and Neston 19.8 Q15 B UB Elmbridge 7.0 Q19 J AK Enfield 23.1 Q05 H UH Epping Forest 13.3 Q03 G UC Epsom and Ewell 6.9 Q19 J UG Erewash 19.3 Q24 E UC Exeter 21.6 Q21 K UE Fareham 7.8 Q17 J UD Fenland 19.8 Q01 G UC Forest Heath 11.1 Q01 G UD Forest of Dean 15.9 Q20 K UF Fylde 13.1 Q13 B CH Gateshead 33.2 Q09 A UE Gedling 16.4 Q24 E UE Gloucester 19.9 Q20 K UF Gosport 16.3 Q17 J UG Gravesham 18.1 Q18 J UD Great Yarmouth 27.7 Q01 G AL Greenwich 31.5 Q07 H UD Guildford 8.3 Q19 J AM Hackney 45.1 Q06 H ET Halton UA 34.3 Q15 B UC Hambleton 10.4 Q11 D AN Hammersmith and Fulham 27.8 Q04 H UD Harborough 7.2 Q25 E AP Haringey 37.7 Q05 H UJ Harlow 21.4 Q03 G UD Harrogate 11.1 Q11 D AQ Harrow 13.5 Q04 H

13 Label Mortality to 2004 IMD 2004: Average Score Underlying cause Motor neurone disease, all ages, Males Mentions StHA GOR Obs. Exp. SMR Obs. Exp. SMR Ratio mentions to underlyin g cause N/A ALL ENGLAND UG Hart 4.2 Q17 J EB Hartlepool UA 37.7 Q10 A UD Hastings 31.7 Q19 J UH Havant 20.1 Q17 J AR Havering 14.8 Q06 H GA Herefordshire, County of UA 15.7 Q28 F UE Hertsmere 12.0 Q02 G UH High Peak 15.1 Q24 E AS Hillingdon 17.7 Q04 H UE Hinckley and Bosworth 11.1 Q25 E UF Horsham 6.7 Q19 J AT Hounslow 23.3 Q04 H UE Huntingdonshire 10.2 Q01 G UG Hyndburn 28.5 Q13 B UD Ipswich 23.4 Q01 G MW Isle of Wight UA 21.1 Q17 J AU Islington 42.7 Q05 H UB Kennet 10.1 Q20 K AW Kensington and Chelsea 21.5 Q04 H UD Kerrier 25.2 Q21 K UE Kettering 15.3 Q25 E UE Kings Lynn and West Norfolk 19.1 Q01 G FA Kingston upon Hull, City of UA 41.1 Q11 D AX Kingston upon Thames 11.6 Q08 H CZ Kirklees 26.2 Q12 D BX Knowsley 46.6 Q15 B AY Lambeth 34.2 Q07 H UH Lancaster 22.3 Q13 B DA Leeds 27.7 Q12 D FN Leicester UA 32.8 Q25 E UF Lewes 12.9 Q19 J AZ Lewisham 28.6 Q07 H

14 Label Mortality to 2004 IMD 2004: Average Score Underlying cause Motor neurone disease, all ages, Males Mentions StHA GOR Obs. Exp. SMR Obs. Exp. SMR Ratio mentions to underlyin g cause N/A ALL ENGLAND UD Lichfield 12.0 Q26 F UD Lincoln 27.2 Q24 E BY Liverpool 49.8 Q15 B KA Luton UA 23.3 Q02 G UG Macclesfield 11.1 Q15 B UH Maidstone 11.5 Q18 J UK Maldon 10.7 Q03 G UC Malvern Hills 13.1 Q28 F BN Manchester 48.9 Q14 B UF Mansfield 32.5 Q24 E LC Medway UA 18.0 Q18 J UG Melton 10.1 Q25 E UB Mendip 14.5 Q22 K BA Merton 14.5 Q08 H UC Mid Bedfordshire 7.7 Q02 G UD Mid Devon 17.1 Q21 K UE Mid Suffolk 9.8 Q01 G UG Mid Sussex 6.4 Q19 J EC Middlesborough UA 40.7 Q10 A MG Milton Keynes UA 15.6 Q16 J UE Mole Valley 6.2 Q19 J UJ New Forest 10.4 Q17 J UG Newark and Sherwood 19.8 Q24 E CJ Newcastle upon Tyne 34.5 Q09 A UE Newcastle-under-Lyme 19.9 Q26 F BB Newham 40.4 Q06 H UE North Cornwall 22.8 Q21 K UE North Devon 20.6 Q21 K UE North Dorset 11.4 Q22 K UJ North East Derbyshire 18.9 Q24 E FC North East Lincolnshire UA 29.4 Q11 D UF North Hertfordshire 10.1 Q02 G

15 Label Mortality to 2004 IMD 2004: Average Score Underlying cause Motor neurone disease, all ages, Males Mentions StHA GOR Obs. Exp. SMR Obs. Exp. SMR Ratio mentions to underlyin g cause N/A ALL ENGLAND UE North Kesteven 11.5 Q24 E FD North Lincolnshire UA 21.2 Q11 D UF North Norfolk 16.9 Q01 G UC North Shropshire 16.6 Q26 F HC North Somerset UA 14.1 Q20 K CK North Tyneside 26.0 Q09 A UB North Warwickshire 16.4 Q28 F UH North West Leicestershire 15.9 Q25 E UC North Wiltshire 8.4 Q20 K UF Northampton 20.2 Q25 E UG Norwich 28.3 Q01 G FY Nottingham UA 41.8 Q24 E UC Nuneaton and Bedworth 21.2 Q28 F UJ Oadby and Wigston 9.7 Q25 E BP Oldham 30.7 Q14 B UD Oswestry 17.1 Q26 F UC Oxford 19.7 Q16 J UJ Pendle 27.6 Q13 B UF Penwith 29.0 Q21 K JA Peterborough UA 23.4 Q01 G HG Plymouth UA 26.2 Q21 K HP Poole UA 14.3 Q22 K MR Portsmouth UA 24.9 Q17 J UK Preston 28.5 Q13 B UG Purbeck 12.6 Q22 K MC Reading UA 18.8 Q16 J BC Redbridge 17.8 Q06 H EE Redcar and Cleveland UA 30.6 Q10 A UD Redditch 19.4 Q28 F UF Reigate and Banstead 9.0 Q19 J UG Restormel 23.9 Q21 K UL Ribble Valley 10.3 Q13 B

16 Label Mortality to 2004 IMD 2004: Average Score Underlying cause Motor neurone disease, all ages, Males Mentions StHA GOR Obs. Exp. SMR Obs. Exp. SMR Ratio mentions to underlyin g cause N/A ALL ENGLAND BD Richmond upon Thames 9.7 Q08 H UE Richmondshire 12.5 Q11 D BQ Rochdale 33.7 Q14 B UL Rochford 8.7 Q03 G UM Rossendale 24.1 Q13 B UG Rother 16.2 Q19 J CF Rotherham 28.2 Q23 D UD Rugby 13.6 Q28 F UG Runnymede 7.8 Q19 J UJ Rushcliffe 9.0 Q24 E UL Rushmoor 10.4 Q17 J FP Rutland UA 6.6 Q25 E UF Ryedale 12.9 Q11 D BR Salford 38.2 Q14 B UD Salisbury 11.8 Q20 K CS Sandwell 35.4 Q27 F UG Scarborough 24.1 Q11 D UG Sedgefield 29.1 Q10 A UC Sedgemoor 17.4 Q22 K CA Sefton 26.1 Q15 B UH Selby 13.1 Q11 D UK Sevenoaks 9.6 Q18 J CG Sheffield 28.4 Q23 D UL Shepway 20.8 Q18 J UE Shrewsbury and Atcham 15.7 Q26 F CT Solihull 16.4 Q27 F UE South Bedfordshire 12.3 Q02 G UE South Bucks 8.1 Q16 J UG South Cambridgeshire 6.4 Q01 G UK South Derbyshire 14.8 Q24 E HD South Gloucestershire UA 9.8 Q20 K UG South Hams 14.2 Q21 K

17 Label Mortality to 2004 IMD 2004: Average Score Underlying cause Motor neurone disease, all ages, Males Mentions StHA GOR Obs. Exp. SMR Obs. Exp. SMR Ratio mentions to underlyin g cause N/A ALL ENGLAND UF South Holland 15.3 Q24 E UG South Kesteven 12.2 Q24 E UG South Lakeland 12.0 Q13 B UH South Norfolk 10.7 Q01 G UG South Northamptonshire 6.6 Q25 E UD South Oxfordshire 7.7 Q16 J UN South Ribble 14.0 Q13 B UF South Shropshire 15.5 Q26 F UD South Somerset 13.7 Q22 K UF South Staffordshire 11.7 Q26 F CL South Tyneside 33.1 Q09 A MS Southampton UA 23.7 Q17 J KF Southend-On-Sea UA 21.7 Q03 G BE Southwark 35.4 Q07 H UH Spelthorne 10.4 Q19 J UG St. Albans 7.7 Q02 G UF St. Edmundsbury 11.5 Q01 G BZ St. Helens 32.0 Q15 B UG Stafford 12.9 Q26 F UH Staffordshire Moorlands 16.5 Q26 F UH Stevenage 15.6 Q02 G BS Stockport 18.1 Q14 B EF Stockton-On-Tees UA 26.3 Q10 A GL Stoke-On-Trent UA 35.3 Q26 F UE Stratford-On-Avon 8.8 Q28 F UF Stroud 10.2 Q20 K UG Suffolk Coastal 11.5 Q01 G CM Sunderland 34.2 Q09 A UJ Surrey Heath 4.9 Q19 J BF Sutton 13.3 Q08 H UM Swale 20.9 Q18 J HX Swindon UA 17.2 Q20 K

18 Label Mortality to 2004 IMD 2004: Average Score Underlying cause Motor neurone disease, all ages, Males Mentions StHA GOR Obs. Exp. SMR Obs. Exp. SMR Ratio mentions to underlyin g cause N/A ALL ENGLAND BT Tameside 29.8 Q14 B UK Tamworth 19.7 Q26 F UK Tandridge 8.3 Q19 J UE Taunton Deane 16.3 Q22 K UH Teesdale 16.4 Q10 A UH Teignbridge 17.0 Q21 K GF Telford and Wrekin UA 21.8 Q26 F UN Tendring 23.1 Q03 G UN Test Valley 8.7 Q17 J UG Tewkesbury 10.1 Q20 K UN Thanet 25.6 Q18 J UJ Three Rivers 9.4 Q02 G KG Thurrock UA 21.2 Q03 G UP Tonbridge and Malling 9.6 Q18 J HH Torbay UA 23.7 Q21 K UK Torridge 21.4 Q21 K BG Tower Hamlets 45.9 Q06 H BU Trafford 20.2 Q14 B UQ Tunbridge Wells 10.5 Q18 J UF Tynedale 15.5 Q09 A UQ Uttlesford 6.7 Q03 G UE Vale of White Horse 6.9 Q16 J UH Vale Royal 17.1 Q15 B DB Wakefield 29.1 Q12 D CU Walsall 29.4 Q27 F BH Waltham Forest 30.2 Q06 H BJ Wandsworth 20.9 Q08 H UG Wansbeck 30.5 Q09 A EU Warrington UA 19.4 Q15 B UF Warwick 12.6 Q28 F UK Watford 14.5 Q02 G UH Waveney 21.8 Q01 G

19 Label Mortality to 2004 IMD 2004: Average Score Underlying cause Motor neurone disease, all ages, Males Mentions StHA GOR Obs. Exp. SMR Obs. Exp. SMR Ratio mentions to underlyin g cause N/A ALL ENGLAND UL Waverley 6.2 Q19 J UH Wealden 9.4 Q19 J UJ Wear Valley 32.6 Q10 A UL Welwyn Hatfield 12.6 Q02 G MB West Berkshire UA 7.9 Q16 J UL West Devon 16.3 Q21 K UH West Dorset 13.3 Q22 K UP West Lancashire 21.1 Q13 B UH West Lindsey 17.7 Q24 E UF West Oxfordshire 6.3 Q16 J UF West Wiltshire 12.0 Q20 K BK Westminster 31.7 Q04 H UJ Weymouth and Portland 21.2 Q22 K BW Wigan 29.3 Q14 B UP Winchester 7.0 Q17 J ME Windsor and Maidenhead UA 8.2 Q16 J CB Wirral 30.1 Q15 B UM Woking 7.3 Q19 J MF Wokingham UA 5.1 Q16 J CW Wolverhampton 32.2 Q27 F UE Worcester 17.7 Q28 F UH Worthing 15.7 Q19 J UF Wychavon 11.3 Q28 F UF Wycombe 9.7 Q16 J UQ Wyre 17.8 Q13 B UG Wyre Forest 17.8 Q28 F FF York UA 14.5 Q11 D

20 Motor neurone disease : SMR for each local authority (underlying cause) - sorted from highest to lowest, Males SMR Melton Alnwick East Hertfordshire North Shropshire North Devon Elmbridge Kennet Watford Blyth Valley Christchurch Fenland Hartlepool UA Stevenage Rutland UA Newark and Sherwood Forest Heath South Oxfordshire Ipswich East Devon Castle Morpeth Epsom and Ewell Northampton Hastings Mendip Mole Valley Halton UA Redditch Kettering Waverley Shrewsbury and Atcham Teesdale Berwick-upon-Tweed Hart Mid Suffolk North East Derbyshire Kingston upon Thames Congleton Ribble Valley High Peak Restormel Spelthorne Rother Derwentside Chester-Le-Street Bromsgrove Kerrier Maidstone Gloucester Daventry Hinckley and Bosworth South Somerset Tonbridge and Malling Thurrock UA Selby Windsor and Maidenhead UA

21 Motor neurone disease : SMR for each local authority (underlying cause) - sorted from highest to lowest, Males SMR West Wiltshire Crewe and Nantwich Bath and North East Somerset UA Durham Reigate and Banstead North Kesteven North Norfolk Wokingham UA Babergh Worcester Uttlesford Stockton-On-Tees UA Chiltern Purbeck North Hertfordshire Dartford Newham South Norfolk Gosport Salisbury Arun Oadby and Wigston Bridgnorth Preston Warrington UA Copeland Ashfield Torbay UA West Devon Huntingdonshire Oswestry Surrey Heath Southampton UA Southend-On-Sea UA Bradford Bournemouth UA Torridge Barrow-In-Furness Milton Keynes UA Woking Guildford South Cambridgeshire Aylesbury Vale Islington Derbyshire Dales South Kesteven Plymouth UA South Hams Blaby Cheltenham East Cambridgeshire Broxtowe Easington South Gloucestershire UA Charnwood

22 Motor neurone disease : SMR for each local authority (underlying cause) - sorted from highest to lowest, Males SMR South Tyneside Braintree Broadland Bromley Poole UA Gravesham Craven Stratford-On-Avon Brighton and Hove UA Camden Havering Warwick Waltham Forest Blackburn with Darwen UA Kirklees Penwith Wansbeck Weymouth and Portland Forest of Dean West Lancashire Wear Valley Worthing Hillingdon Dover Knowsley Mid Devon Nottingham UA Newcastle upon Tyne Thanet Cotswold Sheffield Chester North Tyneside Horsham Walsall Bristol, City of UA Leicester UA Colchester Eastbourne Barnet Taunton Deane West Berkshire UA Chichester Rushcliffe Solihull Derby UA Dacorum Bolsover Fylde St. Helens North Cornwall Chelmsford Blackpool UA East Hampshire Kings Lynn and West Norfolk

23 Motor neurone disease : SMR for each local authority (underlying cause) - sorted from highest to lowest, Males SMR Harborough South Ribble Luton UA Richmond upon Thames Gateshead Teignbridge Wigan West Oxfordshire Dudley Corby East Lindsey Herefordshire, County of UA Havant Fareham Wirral Tamworth Pendle Doncaster Waveney Coventry Oxford Bury Tandridge Rushmoor Leeds Norwich Bexley Wakefield Gedling Ealing Southwark Wyre Forest Bassetlaw Hambleton Harlow Caradon Sefton Tendring Rochdale Chesterfield Kingston upon Hull, City of UA Harrow Lincoln Amber Valley Scarborough Swindon UA East Dorset Great Yarmouth North Warwickshire Stockport Isle of Wight UA Portsmouth UA South Shropshire York UA Carlisle

24 Motor neurone disease : SMR for each local authority (underlying cause) - sorted from highest to lowest, Males SMR Eastleigh Sunderland Wealden Carrick Barnsley Richmondshire Croydon North Wiltshire New Forest Exeter East Staffordshire Tunbridge Wells Wycombe St. Edmundsbury Oldham Stafford West Lindsey Hertsmere North East Lincolnshire UA Lambeth Burnley Medway UA Winchester Three Rivers Suffolk Coastal Birmingham Cherwell Manchester Vale of White Horse Staffordshire Moorlands Lewisham Runnymede Middlesborough UA South Lakeland South Bucks South Derbyshire Harrogate North West Leicestershire Stoke-On-Trent UA Stroud Bedford East Riding of Yorkshire UA North Somerset UA Sedgefield Erewash Rossendale Canterbury Darlington UA Mansfield Vale Royal Wolverhampton South Staffordshire Wyre Sedgemoor South Bedfordshire

25 Motor neurone disease : SMR for each local authority (underlying cause) - sorted from highest to lowest, Males SMR Ashford Nuneaton and Bedworth Trafford Sutton Chorley Salford Newcastle-under-Lyme Bolton East Northamptonshire Test Valley Lewes Lancaster Barking and Dagenham Swale Basingstoke and Deane Ryedale Hyndburn Redbridge Cambridge Breckland Boston Liverpool Greenwich Reading UA Malvern Hills Merton North Lincolnshire UA Basildon Hounslow Sandwell Broxbourne Tameside Peterborough UA Sevenoaks Cannock Chase Telford and Wrekin UA Haringey Redcar and Cleveland UA Maldon Tewkesbury North Dorset Calderdale Rochford Welwyn Hatfield Hammersmith and Fulham Wychavon West Dorset Brentwood Kensington and Chelsea Enfield Tynedale Allerdale Brent Bracknell Forest UA Rotherham

26 Motor neurone disease : SMR for each local authority (underlying cause) - sorted from highest to lowest, Males SMR Lichfield Macclesfield Shepway Tower Hamlets South Holland Mid Sussex Hackney Adur South Northamptonshire Westminster Ellesmere Port and Neston Crawley Mid Bedfordshire Wandsworth Rugby St. Albans Epping Forest

27 Motor neurone disease : SMR for each local authority (mentions) sorted from highest to lowest, Males SMR Melton Hartlepool UA Newark and Sherwood East Hertfordshire South Oxfordshire Elmbridge Alnwick Stevenage Blyth Valley North Shropshire Hart Mendip Tonbridge and Malling Castle Morpeth Ipswich Kennet North Devon Watford Halton UA North Hertfordshire Christchurch Fenland High Peak Mid Suffolk Kingston upon Thames Mole Valley Berwick-upon-Tweed Derwentside Northampton Waverley Uttlesford West Wiltshire Epsom and Ewell Forest of Dean East Devon Dartford Rutland UA Bath and North East Somerset UA North East Derbyshire Forest Heath Bradford Rother Ribble Valley Bromsgrove Shrewsbury and Atcham Southampton UA Wansbeck Charnwood North Norfolk East Cambridgeshire Windsor and Maidenhead UA Reigate and Banstead Redditch Hastings Worcester

28 Motor neurone disease : SMR for each local authority (mentions) sorted from highest to lowest, Males SMR Kettering Spelthorne Restormel Babergh Salisbury Chiltern Camden Teesdale Eastleigh Barrow-In-Furness Newham Gloucester Selby Kerrier South Somerset Hinckley and Bosworth Eastbourne Congleton Arun Ashfield Waltham Forest Derbyshire Dales Cheltenham Bridgnorth South Cambridgeshire Broadland Thurrock UA Preston Oadby and Wigston Aylesbury Vale Crewe and Nantwich Pendle Wear Valley Bromley Chester-Le-Street Torbay UA Gosport Wokingham UA North Kesteven Copeland Dacorum Tandridge Braintree Leicester UA Havering Maidstone Daventry Southend-On-Sea UA Cotswold Weymouth and Portland Stratford-On-Avon Kirklees Newcastle upon Tyne Barnet Guildford

29 Motor neurone disease : SMR for each local authority (mentions) sorted from highest to lowest, Males SMR Plymouth UA Stockton-On-Tees UA Bournemouth UA Walsall Torridge South Kesteven South Tyneside South Gloucestershire UA Bassetlaw South Norfolk Durham Woking Worthing Thanet Warrington UA Rochdale Huntingdonshire St. Helens Blackburn with Darwen UA West Lancashire St. Edmundsbury Craven Hillingdon Milton Keynes UA Vale of White Horse Islington South Bedfordshire South Hams West Oxfordshire Bolsover Runnymede Purbeck Easington Luton UA Knowsley Broxtowe Harborough Brighton and Hove UA Gedling Sheffield Sunderland Surrey Heath Chesterfield Havant Blackpool UA West Devon Penwith Scarborough Bury Chester Oswestry North Tyneside Kings Lynn and West Norfolk Rushcliffe Fylde

30 Motor neurone disease : SMR for each local authority (mentions) sorted from highest to lowest, Males SMR Chelmsford Wirral East Staffordshire Derby UA Wigan Blaby Sedgefield Amber Valley Richmond upon Thames Leeds Nottingham UA Chichester Oldham South Staffordshire Dudley Bexley Gravesham Wycombe Horsham Stockport Poole UA Warwick Gateshead Harrogate West Berkshire UA Taunton Deane Colchester East Lindsey Canterbury Hertsmere Doncaster Wealden North Cornwall Coventry Barnsley South Ribble Wyre Forest Dover Teignbridge Lancaster Mid Devon Caradon Bristol, City of UA Broxbourne Kingston upon Hull, City of UA Wakefield Norwich Rushmoor Solihull Basildon Waveney Swindon UA Nuneaton and Bedworth Herefordshire, County of UA Lambeth

31 Motor neurone disease : SMR for each local authority (mentions) sorted from highest to lowest, Males SMR Burnley Stafford Bedford Fareham Sedgemoor New Forest North Warwickshire South Shropshire Southwark West Lindsey Isle of Wight UA Oxford Sefton Tunbridge Wells Wyre East Hampshire Newcastle-under-Lyme Tameside Hambleton Ealing North East Lincolnshire UA Lincoln Redbridge Trafford Birmingham Harrow Cambridge Corby Wolverhampton Portsmouth UA Ryedale Tamworth Barking and Dagenham Sandwell Tynedale Great Yarmouth East Riding of Yorkshire UA Croydon Carlisle Salford Mansfield Erewash East Dorset Sevenoaks Suffolk Coastal Middlesborough UA Manchester Carrick Tendring North Lincolnshire UA Lewes Three Rivers Tewkesbury Exeter North Wiltshire

32 Motor neurone disease : SMR for each local authority (mentions) sorted from highest to lowest, Males SMR Medway UA Liverpool South Bucks York UA Harlow Bolton Rotherham South Derbyshire Winchester Lewisham Stoke-On-Trent UA North Somerset UA Staffordshire Moorlands Merton South Holland Breckland Swale South Lakeland Darlington UA Stroud Richmondshire Malvern Hills Basingstoke and Deane Kensington and Chelsea Sutton Vale Royal Hyndburn Hounslow Reading UA Cherwell Lichfield Boston Redcar and Cleveland UA Test Valley North West Leicestershire Rossendale Greenwich Peterborough UA Maldon Haringey Calderdale Ellesmere Port and Neston Shepway Hammersmith and Fulham Chorley Ashford Adur Brent East Northamptonshire Allerdale North Dorset Enfield Rochford West Dorset Telford and Wrekin UA

33 Motor neurone disease : SMR for each local authority (mentions) sorted from highest to lowest, Males SMR Brentwood Welwyn Hatfield Wandsworth Bracknell Forest UA Wychavon Cannock Chase Hackney Tower Hamlets South Northamptonshire Mid Sussex Macclesfield Westminster Crawley Mid Bedfordshire St. Albans Rugby Epping Forest

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