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Follow-up report No.4 Report reference:, Reference OIE : 13123, Report Date : 23/03/2013, Country : Mexico Report Summary Name of sender of the report Dr Joaquín Braulio Delgadillo Álvarez Telephone +52 55 59 05 10 00 Position Director General de Salud Animal Fax Address Avenida Cuauhtémoc N 1230 - Piso 9 Email joaquin.delgadillo@senasica.gob.mx Colonia Santa Cruz Atoyac Delegación Benito Juárez CP 03310 México DF Mexico Date submitted to OIE 23/03/2013 Animal type Terrestrial Date of report 23/03/2013 Disease Highly pathogenic avian influenza Date of start of the event 03/01/2013 Causal Agent Highly pathogenic avian influenza virus Date of pre-confirmation of the 07/01/2013 event Serotype(s) H7N3 Date of last occurrence 29/09/2012 Reason Reoccurrence of a listed disease Diagnosis Clinical, Laboratory (basic), Laboratory (advanced) Country or zone a zone or compartment Clinical signs Yes Number of reported outbreaks submitted= 37, Draft= 0 Outbreak details AGUASCALIENTES-oth er - San Francisco de los Romo Farm San Francisco de los Romo Birds Animals 146755 2990 740 0 146015 22.0690167-102.270406 03/01/2013 08/01/2013 AGUASCALIENTES-oth - Aguascalientes Farm Aguascalientes 22.0690168-102.270406 05/01/2013 08/01/2013 er Birds Animals 138000... 0 0 138000 JALISCO-other report - - Encarnación de Díaz Encarnación de Díaz Farm Encarnación de Díaz 1 20.5164222-102.233728 12/01/2013 submitted Birds Animals 191771 10010 9077 0 0 JALISCO-other report - - Encarnación de Díaz Encarnación de Díaz Farm Encarnación de Díaz 2 21.3164222-102.133728 12/01/2013 submitted Birds Animals 205742 10058 8932 0 0 GUANAJUATO-other - Dolores Hidalgo Farm Dolores Hidalgo 2 21.15775-100.93364 12/02/2013 Printed on: Mon Mar 25 13:17:58 CET 2013 Page 1/8

Birds Animals 40000 5000 2000 38000 0 JALISCO- (this report - - Tepatitlán de Morelos Farm Tepatitán de Morelos 20.844269-102.74555 12/02/2013 Birds Animals 178029 3000 3000 0 0 Four commercial flocks of layers GUANAJUATO-other - Dolores Hidalgo Farm Dolores Hidalgo 1 21.15775-100.93564 12/02/2013 Birds Animals 40000 9000 3500 36500 0 GUANAJUATO-other - Dolores Hidalgo Farm Dolores Hidalgo 3 21.15775-100.93664 12/02/2013 Birds Animals 61242 5500 5088 56154 0 GUANAJUATO-other - San Luis de La Paz Farm San Luis de La Paz 21.2757468-100.725 12/02/2013 Birds Animals 210000 7500 5000 205000 0 GUANAJUATO-other - Juventino Rosas Farm Juventino Rosas 20.6435083-100.995797 12/02/2013 Birds Animals 108500 452 450 108050 0 GUANAJUATO-other - Dolores Hidalgo Farm Dolores Hidalgo 4 21.15775-100.93264 12/02/2013 Birds Animals 35000 5000 1500 33500 0 GUANAJUATO-other - Dolores Hidalgo Farm Dolores Hidalgo 5 21.15775-100.93464 12/02/2013 Printed on: Mon Mar 25 13:17:58 CET 2013 Page 2/8

Birds Animals 40000 18000 16000 24000 0 GUANAJUATO-other - San Felipe Farm San Felipe 21.51111-101.53111 12/02/2013 Birds Animals 73000 1101 1101 71899 0 GUANAJUATO-other - Dolores Hidalgo Farm Dolores Hidalgo 6 21.15775-100.93164 12/02/2013 Birds Animals 40000 2000 250 39750 0 GUANAJUATO- (this - Dolores Hidalgo Farm Dolores Hidalgo 21.15775-100.94414 15/02/2013 ) Birds Animals 38739 6081 5125 0 0 GUANAJUATO-other - Dolores Hidalgo Farm Dolores Hidalgo 2 21.15775-100.93964 16/02/2013 Birds Animals 26171 187 187 0 0 GUANAJUATO-other - Dolores Hidalgo Farm Dolores Hidalgo 1 21.15775-100.93864 16/02/2013 Birds Animals 35000 2000 1000 0 0 GUANAJUATO-other - Dolores Hidalgo Farm Dolores Hidalgo 21.15775-100.93914 17/02/2013 Birds Animals 71292 522 347 0 0 GUANAJUATO-other - San Miguel de Allende Farm San Miguel de Allende 20.9141611-100.743714 18/02/2013 Printed on: Mon Mar 25 13:17:58 CET 2013 Page 3/8

Birds Animals 40000 26665 21700 0 0 GUANAJUATO-other - Juventino Rosas Farm Juventino Rosas 2 20.6435083-100.995589 19/02/2013 Birds Animals 100326 1000 800 0 0 JALISCO- (this report - - Lagos de Moreno Farm Lagos de Moreno 21.479039-101.7555 19/02/2013 Birds Animals 1752391 396200 388499 0 0 15 flocks of broilers GUANAJUATO-other - Juventino Rosas Farm Juventino Rosas 1 20.6435083-100.995997 19/02/2013 Birds Animals 107212 1000 800 0 0 GUANAJUATO-other - San Luis de La Paz Farm San Luis de La Paz 21.2757468-100.625 20/02/2013 Birds Animals 189000 1000 571 0 0 JALISCO- (this report - - Lagos de Moreno Farm Lagos de Moreno 21.479039-101.7666 20/02/2013 Birds Animals 2000 100 100 0 0 A commercial flock of layer Japanese quails JALISCO- (this report - - Encarnación de Díaz Farm Encarnación de Díaz 21.3164222-102.133555 20/02/2013 Birds Animals 374699 39644 7100 0 0 Two flocks of broilers GUANAJUATO-other - León Farm León 21.1326611-101.678292 20/02/2013 Printed on: Mon Mar 25 13:17:58 CET 2013 Page 4/8

Birds Animals 112501 25000 20335 0 0 GUANAJUATO-other - San Miguel de Allende Farm San Miguel de Allende 20.9141611-100.743614 21/02/2013 Birds Animals 182354 2500 2168 0 0 GUANAJUATO-other - Dolores Hidalgo Farm Dolores Hidalgo 21.15775-100.94114 23/02/2013 Birds Animals 40000 2200 1673 0 0 GUANAJUATO-other - Celaya Farm Celaya 21.15775-100.94114 23/02/2013 Birds Animals 110162 84 84 0 0 GUANAJUATO- (this - Dolores Hidalgo Farm Dolores Hidalgo 21.15775-100.94314 25/02/2013 ) Birds Animals 34317 16699 329 0 0 GUANAJUATO- (this - Juventino Rosas Village Juventino Rosas 20.6435083-100.99579 25/02/2013 ) Birds Animals 43 3 3 0 0 GUANAJUATO- (this - Dolores Hidalgo Farm Dolores Hidalgo 21.15775-100.94314 25/02/2013 ) Birds Animals 7452 2100 1405 0 0 JALISCO- (this report - - Tepatitlán de Morelos Farm Tepatitlán de Morelos 20.844269-102.74666 25/02/2013 Printed on: Mon Mar 25 13:17:58 CET 2013 Page 5/8

Birds Animals 10 3 2 0 0 Backyard poultry GUANAJUATO- (this - San Miguel de Allende Farm San Miguel de Allende 20.9158-100.74238 26/02/2013 ) Birds Animals 42719 9464 944 0 0 GUANAJUATO- (this - Comonfort Farm Comonfort 20.7171806-100.754428 27/02/2013 ) Birds Animals 22900... 0 0 0 JALISCO- (this report - - Unión de San Antonio Farm Unión de San Antonio 21.198203-102.123555 27/02/2013 Birds Animals 11 6 0 0 0 Backyard poultry GUANAJUATO- (this - San Miguel de Allende Village San Miguel de Allende 20.9158-100.75238 28/02/2013 ) Birds Animals 70 6 2 0 0 Outbreak summary: Total outbreaks = 37 (Submitted) Species Susceptible Cases Deaths Destroyed Slaughtered Birds 4797408 612075 509812 612853 284015 Epidemiology Epidemiological comments Following the epidemiological investigation on the event occurred in Guanajuato, 7 outbreaks due to highly pathogenic avian influenza virus were identified (5 heavy breeder farms and 2 backyards) with a total affected population of 146,240 birds. These outbreaks were located in the municipalities of Dolores Hidalgo (4), Juventino Rosas (1) and San Miguel de Allende (2). In Jalisco, 2 outbreaks in broiler farms, one in Lagos de Moreno (15 flocks) and another in Encarnación de Díaz (2 flocks) were identified. In commercial layer farms, one outbreak was identified in Tepatitlán de Morelos (4 flocks), one in quails (Lagos de Moreno) and 2 in backyards (Tepatitlán de Morelos and Unión de San Antonio). The affected population is 2,307,140 birds. Simultaneously, depopulation activities have begun in the affected farms and preventive vaccination is still on-going in high risk birds. From January to 15 March 2013, 44.6 million doses were applied. Source of the outbreak(s) or origin of infection Unknown or inconclusive Measures applied Applied To be applied Printed on: Mon Mar 25 13:17:58 CET 2013 Page 6/8

Applied To be applied quarantine stamping out movement control inside the country screening zoning vaccination in response to the outbreak (s) disinfection of infected premises/establishment(s) Animals treated Vaccination Prohibited No No Vaccination in response to outbreak estado Species Number Vaccinated Details GUANAJUATO Birds 5512080 Breeder and layer commercial farms Future Reporting The event is continuing. Weekly follow-up reports will be submitted. Printed on: Mon Mar 25 13:17:58 CET 2013 Page 7/8

Outbreak maps Printed on: Mon Mar 25 13:17:58 CET 2013 Page 8/8