TP53 Certification - Summary of Rounds 1-5 & update on Round 6. Sarka Pospisilova Sarka Pavlova + TP53 Network certifying centres

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TP53 Certification - Summary of Rounds 1-5 & update on Round 6 Sarka Pospisilova Sarka Pavlova + TP53 Network certifying centres

TP53 Certification Summary of Certification Rounds 1-5 (2014 2017)

Finalized Certification Rounds Rounds Certified Centres Certified Countries Unsuccessful Centres Round 1 30 11 7 Round 2 16 13 9 Round 3 29 14 7 Round 4 35 16 2 Round 5 17 13 4 Total 117* 25 27 * Certified centres : 8 centres participated in 2 rounds with different techniques 1 centre participated in 2 rounds with the same technique 1 centre with 2 departments participated in 1 round with 2 different techniques Certified centres - some centres certified in more than one round. Unsuccessful centres - some centres failed in more than one round

ERIC Certified Centres - 5 Rounds 117 certified centres 25 certified countries 27 unsuccessful centres

ERIC Certified Centres (25 countries) http://www.ericll.org/certified-centres/

TP53 Certification Update on Round 5 (completed in 2017) Project details & deadlines: Project lead by: Uppsala University (Sweden) L.A. Sutton, R. Rosenquist Original applicants: 35 Participating centres: 22 Number of participating countries: 16 Samples sent to participants: 23 August 2017 Deadline to submit results: 23 October 2017 Deadline to receive reports: December 2017

Round 5 - List of Participating Centres (22) Austria Medical University of Vienna (Vienna) Belgium Hospital Erasme (Brussels) UZ Leuven (Leuven) Brazil Instituto Nacional de Câncer-INCA (Rio de Janiero) Czech Republic University Hospital Brno (Brno) Denmark Odense University Hospital (Odense) Finland Tykslab (Turku) France CHU Bordeaux (Pessac) EFSBFC (Besancon) Germany Labor Dr. Wisplinghoff (Cologne) MVZ Dr. Eberhard & Partner Dortmund (Dortmund) AgenDix GmbH (Dresden) Hungary Semmelweis University (Budapest) Italy Asst Papa Giovanni XXIII (Bergamo) University of Bari (Bari) Poland The Maria Skłodowska Curie Memorial Cancer Centre and Institute of Oncology (MCMCC) (Warsaw) Spain Hospital La Fe (Valencia) Sweden Sahlgrenska University Hospital (Goteborg) Switzerland Kantonsspital St.Gallen (St. Gallen) The Netherlands UMC Utrecht (Utrecht) - 2 different departments The United Kingdom John Radcliffe Hospital (Oxford)

ERIC Certified Centres in Round 5 18 certified centres from 13 countries 4 unsuccessful centres

TP53 Certification Update on Round 6 (ongoing) Project details & deadlines: Project being lead by: University Hospital Brno (Czech Republic) Original applicants: 61 Participating centres: 41 Number of participating countries: 17 Samples sent to participants: 3 April 2018 Deadline to submit results: 3 June 2018 Deadline to receive reports: 28 July 2018

Round 6 - Participating Centres (41)

Round 6 - RESULTS NGS Sanger sequencing

TP53 Certification planned Round 7 Round 7 is due to open in September 2018. Applicants who failed in Round 6 will be given a priority in the next round. Laboratories interested in participation should complete the online participation form as soon as possible using http://www.ericll.org/tp53network/. Once the form has been completed, laboratories must confirm their participation and provide their shipping details. Samples for analysis and instructions will be sent. Results to be submitted online. Specific information regarding this Round will be added to the ERIC website and a newsletter will be circulated to ERIC Members nearer to the date. Assistance to be provided throughout the Certification Process: Guidance tools & Online Help Desk.

For more information on the TP53 Network www.ericll.org/tp53network

Leukemia (2018), Vol. 32 Issue 5, May 2018

Certifying Centers: Jitka Malčíková Šárka Pavlová Veronika Navrkalová Lesley Ann Sutton Richard Rosenquist Eugen Tausch Stephan Stilgenbauer ERIC Executive Office - Natalie Sorolla Paolo Ghia Kostas Stamatopoulos Arnon Kater Carol Moreno Emili Montserrat Training Centers Representatives THANK YOU VERY MUCH FOR YOUR ATTENTION!