Organ Transplantation in Brazil

RBT ian Transplantation Registry Official report of ian Organ Transplantation Society 2014 XIX YEAR Nº 4 Organ Transplantation in (2007-2014) In absolute numbers holds the second largest kidney and liver transplant programs in the world. Still organ donation and the allocation systems have to improve and regional disparities have to be resolved. The population belief in organ donation along with government and medical societies support and the dedication of health care professional are of utmost importance for the success of the ian Transplantation Program. 20000 15000 10000 5000 Estimated demand and number of transplants performed in in 2014 Estimated demand Performed transplants 15 12 9 6 3 Annual evolution of effective donors in - pmp (per million population) 6.3 7.2 9.0 9.9 10.7 12.6 13.2 14.2 0 Cornea Kidney Liver Heart Lung Pancreas 0 ian Association of Organ Transplantion

ian Transplantation Registry Official report of ian Organ Transplantation Society ApoioRBT Board of Directors: (Biennium 2012-2013) President: Lucio Pacheco Vice-President: Roberto C. Manfro 1st Secretary: Tainá V. de Sandes Freitas 2nd Secretary: Agnaldo Soares Lima Treasurer: Paulo M. Pêgo Fernandes 2nd Treasurer: Eliana Régia Barbosa Advisory Council: President : Ben-Hur Ferraz Neto Secretary: José O. Medina Pestana Valter Duro Garcia Elias David-Neto Jorge Neumann Maria Cristina Ribeiro de Castro Departaments Anesthesiology / Intensive Care: Leonardo Jose Rolim Ferraz Ethics: Mário Abbud Filho Heart Transplantation: Alfredo Inacio Fiorelli Immunobiology: Maria Gerbase de Lima Kidney Transplantation: Marilda Mazzali Liver Transplantation: Paulo Massarollo Lung Transplantation: José Eduardo Afonso Júnior Nursing: Bartira de Aguiar Roza Pancreas Transplantation: Adriano Miziara Gonzalez Pediatric Transplantation: Clotilde D, Garcia Tissue Transplantation: Rafael Augusto Dantas Prinz Transplant Coordination: Joel de Andrade Expedients: Editor: Valter Duro Garcia Associate Editor: Lucio Pacheco Thiago Quintas Camara (thiago@abto,org.br) Data Management / Creation and Production Headquarters: ian Organ Transplantation Society- ABTO Av, Paulista, 2001-17º andar - cj 1704 / 1707 São Paulo - SP CEP 01311-300 Phones: 55 11 3283-1753 / 3262-3353 Fax: 55 11 3289-3169 e-mail: abto@abto,org.br www,abto,org.br

EDITORIAL Looking at the ian transplant teams active in 2014 we realize that the number of kidney and liver teams is adequate to the size of the ian population but could be better distributed in the territory. This is probably also applicable to the heart and pancreas teams but there is a huge paucity of lung transplant teams. Annual Planning of Effective donors (2007-2017) Goal Performed In 2014 a 7.6% increment in donations was observed which puts us bellow the goal established in 2007 of reaching a 15.0 pmp rate in 2014 and makes more difficult to reach the 2017 planned rate of 20.0 donors pmp which may be reached in 2018. still has an elevated rate of family non consent in donation (46%) and we believe it is reachable to decrease this rate by 2% per year down to 30%. Donors cardiac arrest accounts for 14.5% of non donation and could perhaps be lowered by improving donor care. Medical contra indication for donation, also 14.5%, can also be lowered to around 10% by using more liberal criteria for accepting donors. Kidney transplantation has being increasing since 2007. In 2014 the increment was 3.5%. Deceased donor increased 4.7% and the living donation remained stable with changes in the types of living donors, an increment in unrelated donation and a decrease in the numbers of living related donors. Two ian states (RS and SP) performed more than 50 kidney transplants pmp with 40 transplants pmp with deceased donors in these same states. In on state only (PR) reached the rate of 15 transplants pmp with living donors. The number of liver transplants has being increasing since 2008. However the number increased by only 1.9% in 2014. Decease d donor transplants increased by 1.1% and living donation increased 10.3%. Only two states (CE and DF) reached the rate of 20 liver transplants pmp. The number of pancreas transplants further dropped (11.3%) in 2014, trend that has being observed since 2011. Among the reasons for this are perhaps the inadequate financial support in this modality, complexity of the procedure and the low number of appropriate donors. Only one state (PR) reached 2 pancreas transplants pmp. Heart transplants have being increasing since 2006 and a further increase of 14.8% occured in 2014 reachin 1.5 transplants pmp for the first time. One state (DF) performed 9.7 heart transplants pmp in 2014. The number of lung transplants decreased 16.2% in 2014. A rate of only 0.4 transplants pmp was reached accounting for only 5% of the estimated need in the country. This is perhaps due to the very low number of teams in the country Bone marrow transplants have being increasing since 2004 and further increased by 8.3% this year reaching 2013 procedures. The need for BMT has not being adequately estimated in the country. Only three states (PE, SP and DF) performed more than 20 transplants pmp and only one (PR) performed more than 10 transplants PMP with allogeneic donors The number of corneal transplants is decreasing since 2012 and further dropped by 5.2% this year. Also the number of patients on the waiting list is also decreasing. Only three states (DF, GO, SP and SC) performed more than 100 transplants pmp and these states have large waiting lists. A positive fact is that the North region of the country has increased substantially the rate of donation, that increased 6.6 times in seven years, kidney transplants (5.4 times) and liver transplant programs were established. Lucio Pacheco Valter Duro Garcia abto@abto.org.br

Sumário BRAZIL S STANDING IN GLOBAL FIGURES 3 BRAZILIAN DATA 6 Annual number of transplants in from 2004 to 2014 8 KIDNEY 9 LIVER 10 HEART 11 PANCREAS 12 LUNG 13 Bone Marrow and Tissue 14 CORNEA 15 BONE 15 PEDIATRIC TRANSPLANTS 16 BRAZILIAN REGIONAL DATA 18 GENERAL INFORMATION 19 ORGAN DONATION 19 TISSUE TRANSPLANTS 19 ORGAN TRANSPLANTS 20 DATA BY STATE 22 Pacients on waiting list (december 2014) 22 Organ Donation for 2014 22 Number of Notifications of potential donors, effective donors and donors whose organs were transplanted by State during the year 2014 23 Causes of non-fulfillment of organ donation of notified potential donors during the year 2014 24 Profile: age, gender, cause of death and blood group of the organ donors 25 Acre 26 Alagoas 28 Amapá 30 Amazonas 32 Bahia 34 Ceará 36 Distrito Federal 38 Espirito Santo 40 Goiás 42 Maranhão 44 Mato Grosso 46 Mato Grosso do Sul 48 Minas Gerais 50 Pará 52 Paraíba 54 Paraná 56 Pernambuco 58 Piaui 60 Rio de Janeiro 62 Rio Grande do Norte 64 Rio Grande do Sul 66 Rondônia 68 Roraima 70 Santa Catarina 72 São Paulo 74 Sergipe 76 Tocantins 78

BRAZIL S STANDING IN GLOBAL FIGURES is ranked second in absolute number of kidney transplants (from 30 countries) - Year 2013 Source: IRODAT 2013 living donors deceased donors is ranked second in absolute number of liver transplants (from 30 countries) - Year 2013 living donors deceased donors 3

BRAZIL S STANDING IN GLOBAL FIGURES Source: IRODAT 2013 Kidney transplants (pmp). by type of donor. during the year 2013. (50 countries) living donors deceased donors 35º Liver transplants (pmp), by type of donor, during the year 2013. (50 countries) living donors deceased donors 25º 4

BRAZIL S STANDING IN GLOBAL FIGURES Source: IRODAT 2013 Number of effective donors (pmp) in the year 2013. (50 countries) Kidney transplants (pmp) from deceased donors during the year 2013. (50 countries) 30º 27º 5

BRAZILIAN DATA Population 190,755,799 Area(Km 2 ) 8,514,876.60 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 17,168 11,445 4,769 1,145 Transplants performed 13,036 5,639 1755 311 Number of deaths per year All causes 1,047,824 1,077,007 1,103,088 1,136,947 1,170,498 1,181,166 Unavailable Unavailable External causes 131,032 135,936 138,697 143,256 145,842 152,013 Unavailable Unavailable Neurological causes 20,413 21,609 23,018 25,303 26,948 28,712 Unavailable Unavailable Population (IBGE census) 183,987,291 183,987,291 183,987,291 190,755,799 190,755,799 190,755,799 190,755,799 190,755,799 Hospital Total number 6,097 State capitals 1,291 Country side 4,806 Nº of beds 468,640 Nº of ICU beds 38,697 Hospitals over 80 beds 1,745 Teaching hospitals 140 Medical schools 222 Neurosurgery services 415 Number of CIHDOTTS 628 Number of OPOs 43 Source: http://cnes,datasus,gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp has a well established transplant program. However, much care has to be taken to assure continuous growing in order to fulfill the needs of a population of more than 190 million. The challenge of providing enough transplants has being achieved for corneal transplantations but much has to be done in order to provide enough transplants for the other organs which is far from being accomplished. The number of transplants is increasing continuously by the efforts of numerous individuals acting in the chain of donation and mainly by the generosity of donors and their families. ORGAN DONATION Effective donor - pmp Number of effective donors 1,150 1,317 1,658 1,898 2,048 2,406 2,526 2,713 Number of effective donor (pmp) 6.3 7.2 9.0 9.9 10.7 12.6 13.2 14.2 Potential donors 5,494 5,992 6,490 6,979 7,238 8,025 8,871 9,351 Number of potential donors(pmp) 29.9 32.6 35.3 36.6 37.9 42.1 46.5 49.0 Non consenting families 1507 1329 1390 1800 1937 2315 2,622 2,610 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 41% 47% 46% Cardiopulmonary Arrest Unavailable 1428 1350 1279 1205 1188 1,292 1,156 Medical Contraindications 1832 839 1101 991 832 836 1,150 1,349 Others 1005 1079 991 1011 1216 1280 1,281 1,523 6

Kidney from deceased donor - pmp BRAZILIAN DATA Organ Transplantation Kidney from living donor - pmp Liver - pmp Cornea- pmp Number of teams that performed transplantations during the year Cornea Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Kidney 140 142 140 140 126 124 129 135 Liver 49 48 51 55 57 59 60 64 Pancreas 29 26 21 21 26 19 21 15 Heart 33 30 33 26 27 27 33 31 Lung 4 4 5 4 6 6 7 6 Absolute number of transplants Cornea 9,040 13,341 12,723 12,778 14,696 15,281 13,744 13,036 Kidney 3,462 3,815 4,285 4,656 4,975 5,413 5,447 5,639 living donors 1,713 1,780 1,742 1,655 1,650 1,499 1,382 1,384 deceased donors 1,749 2,035 2,543 3,001 3,325 3,914 4,065 4,255 Liver 1,008 1,177 1,334 1,413 1,496 1,598 1,723 1,755 Pancreas 163 174 160 133 181 151 142 126 Heart 161 201 201 166 160 228 271 311 Lung 46 53 59 61 49 69 80 67 Number of transplants pmp Cornea 49.1 72.5 69.2 67.0 77.0 80.1 72.1 68.3 Kidney 18.8 20.7 23.3 24.4 26.1 28.4 28.6 29.6 living donor 9.3 9.7 9.5 8.7 8.6 7.9 7.2 7.3 deceased donor 9.5 11.1 13.8 15.7 17.4 20.5 21.3 22.3 Liver 5.5 6.4 7.3 7.4 7.8 8.4 9.0 9.2 Pancreas 0.9 0.9 0.9 0.7 0.9 0.8 0.7 0.7 Heart 0.9 1.1 1.1 0.9 0.8 1.2 1.4 1.6 Lung 0.3 0.3 0.3 0.3 0.3 0.4 0.4 0.4 7

Annual number of transplants in between 2004 and 2014 6000 Absolute number of transplants(annual) 5,639 - Kidney 5000 number of transplant 4000 3000 2000 1,755- Liver 1000 0 2004 2005 2006 311 - Heart 126 Pancreas 67 - Lung jan/2004 until dec/2014 1997 until Dec/2014 Heart 211 181 149 161 201 201 166 160 228 271 311 2,240 3,290 Liver 959 949 1,037 1,008 1,177 1,334 1,413 1,496 1,598 1,723 1,755 14,449 17,793 Pancreas 256 178 191 163 174 160 133 181 151 142 126 1,855 2,441 Lung 46 45 49 46 53 59 61 49 69 80 67 624 825 Kidney 3,504 3,367 3,285 3,462 3,815 4,285 4,656 4,975 5,413 5,447 5,639 47,848 68,901 30 Number of transplants (pmp) 29.6 - Kidney number of transplants per million population 25 20 15 10 9.2- Liver 5 0 2004 2005 2006 Heart 1.2 1.1 0.9 0.9 1.1 1.1 0.9 0.8 1.2 1.4 1.6 Liver 5.6 5.6 6.1 5.5 6.4 7.3 7.4 7.8 8.4 9.0 9.2 Pancreas 1.5 1.0 1.1 0.9 0.9 0.9 0.7 0.9 0.8 0.8 0.7 Lung 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.4 0.4 0.4 Kidney 20.6 19.8 19.3 18.8 20.7 23.3 24.4 26.1 28.4 28.6 29.6 1.6 - Heart 0.7 - Pancreas 0.4 - Lung 8

Annual number of transplants in between 2004 and 2014 Kidney (in 21 state, with 135 active teams) Annual Number of Transplants by donor type number of transplant 5000 4000 3000 2000 1000 4,255 Deceased 1,384 - Living 1,102 - Related 0 186 - Spouse 96 -unrelated 2004 2005 2006 Deceased 1,800 1,617 1,525 1,749 2,035 2,543 3,001 3,325 3,914 4,065 4,255 Living 1,704 1,750 1,760 1,713 1,780 1,742 1,655 1,650 1,499 1,382 1,384 Related 1,448 1,461 1,479 1,429 1,457 1,446 1,370 1,352 1,226 1,129 1,102 Unrelated - Spouse 164 184 159 164 197 187 175 185 196 186 186 Unrelated - other 92 105 122 120 126 109 110 113 77 67 96 Total 3,504 3,367 3,285 3,462 3,815 4,285 4,656 4,975 5,413 5,447 5,639 Number of transplants by state during the year 2014 UF Living Deceased Total SP 594 1518 2112 MG 186 402 588 RS 79 476 555 RJ 94 374 468 PR 178 254 432 SC 33 260 293 CE 13 270 283 PE 26 253 279 DF 10 90 100 ES 29 59 88 BA 19 63 82 RN 9 60 69 GO 22 43 65 PA 13 37 50 PB 22 17 39 PI 13 22 35 MA 16 18 34 AL 14 12 26 AM 10 12 22 RO 1 10 11 AC 3 5 8 1,384 4,251 5,639 number of transplant 2000 1500 1000 500 deceased donor living donor 0 SP MG RS RJ PR SC CE PE DF ES BA RN GO PA PB PI MA AL AM RO AC Survival Curves: Registry set up on 2010-01-01 Number of transplants per million population by state during the year 2014 1.0 0.8 0.6 0.4 0.2 0.0 donor: 5590 (28%) - living 14,235 (72%) - deceased 94% Patient (living donor) 88% Graft (living donor) 87% Patient (deceased donor) 75% Graft (deceased donor) Active Reported 100% transplant Teams 169 89 (53%) Transplants 26,130 19,825 (76%) 0 1 2 3 4 5 year Cumulative survival include data from transplant teams who reported 100% of their results during the period state Living Deceased Total RS 7.4 44.5 51.9 SP 14.4 36.8 51.2 SC 5.3 41.6 46.9 PR 17.0 24.3 41.4 DF 3.9 35.0 38.9 CE 1.5 31.9 33.5 PE 3.0 28.8 31.7 MG 9.5 20.5 30.0 RJ 5.9 23.4 29.3 ES 8.3 16.8 25.0 RN 2.8 18.9 21.8 PI 4.2 7.1 11.2 AC 4.1 6.8 10.9 GO 3.7 7.2 10.8 PB 5.8 4.5 10.4 AL 4.5 3.8 8.3 RO 0.6 6.4 7.0 PA 1.7 4.9 6.6 AM 2.9 3.4 6.3 BA 1.4 4.5 5.9 MA 2.4 2.7 5.2 7.3 22.3 29.6 number of transplants per million population 50 deceased donor 40 living donor 30 20 10 0 RS SP SC PR DF CE PE MG RJ ES RN PI AC GO PB AL RO PA AM BA MA 9

Annual number of transplants in between 2004 and 2014 Liver - (in 15 states, with 64 active teams) number of transplant Annual Number of Transplants by donor type 1600 1200 800 400 0 2004 2005 2006 Deceased 777 757 847 862 1055 1214 1313 1392 1481 1587 1605 Living 182 192 190 146 122 120 100 104 117 136 150 Related 151 164 163 123 107 108 88 93 106 123 125 Unrelated 31 28 27 23 15 12 12 11 11 13 25 Total 959 949 1037 1008 1177 1334 1413 1496 1598 1723 1755 1,605 Deceased 150 Living 125 related 25 unrelated Number of transplants by state during the year 2014 state Living Deceased total number of transplants SP 108 547 655 CE 3 192 195 RJ 22 166 188 RS 10 132 142 PE 3 112 115 SC 0 113 113 PR 4 95 99 MG 0 91 91 DF 0 54 54 BA 0 53 53 ES 0 40 40 AC 0 4 4 AM 0 3 3 RN 0 2 2 PB 0 1 1 150 1605 1755 700 600 500 400 300 200 100 deceased donor living donor 0 SP CE RJ RS PE SC PR MG DF BA ES AC AM RN PB 1.0 Survival Curve: Registry set up on 2010-01-01 Number of transplants per million population by state during the year 2014 0.8 25 10 0.6 0.4 0.2 0.0 69 Patient 65 % Graft Active Reported 100% Transplant Teams 79 52 (66%) Transplants 7,985 6,721 (84%) 0 1 2 3 4 5 years Cumulative survival include data from transplant teams who reported 100% of their results during the period State Living Deceased Total CE 0.4 22.7 23.1 DF 0.0 21.0 21.0 SC 0.0 18.1 18.1 SP 2.6 13.3 15.9 RS 0.9 12.3 13.3 PE 0.3 12.7 13.1 RJ 1.4 10.4 11.8 ES 0.0 11.4 11.4 PR 0.4 9.1 9.5 AC 0.0 5.4 5.4 MG 0.0 4.6 4.6 BA 0.0 3.8 3.8 AM 0.0 0.9 0.9 RN 0.0 0.6 0.6 PB 0.0 0.3 0.3 0.8 8.4 9.2 number of transplants per million population 20 15 10 5 deceased donor living donor 0 CE DF SC SP RS PE RJ ES PR AC MG BA AM RN PB

Annual number of transplants in between 2004 and 2014 Heart - (in 11 states, with 31 active teams) 400 Annual number in Annual number of transplants by state during the year 2014 150 300 311 number of transplant 200 100 State Total SP 134 MG 39 PR 32 DF 25 PE 25 CE 21 number of transplants 120 90 60 RJ 12 0 2004 2005 2006 Heart 211 181 149 161 201 201 166 160 228 271 311 RS 9 ES 7 SC 4 AL 3 311 30 0 SP MG PR DF PE CE RJ RS ES SC AL Survival Curve: Registry set up on 2010-01-01 Number of transplants per million population by state during the year 2014 1.0 10.0 0.8 0.6 0.4 0.2 0.0 60 % Patient Active Reported 100% Transplant Teams 41 25 (61%) Transplants 1,136 845 (74%) 0 1 2 3 4 5 years Cumulative survival include data from transplant teams who reported 100% of their results during the period State Total DF 9.7 SP 3.2 PR 3.1 PE 2.8 CE 2.5 ES 2.0 MG 2.0 AL 1.0 number of transplants per million population 8.0 6.0 4.0 2.0 RS 0.8 RJ 0.8 SC 0.6 1.6 0.0 DF SP PR PE CE ES MG AL RS RJ SC 11

Annual number of transplants in between 2004 and 2014 Pancreas - (in 7 states, with 15 active teams) 200 Annual number in Number of transplants by state during the year 2014 80 number of transplant 150 100 50 0 2004 2005 2006 Pancreas/Kidney 155 115 128 106 140 121 87 129 120 120 103 Pancreas after kidney 17 24 34 41 21 13 18 Pancreas alone 17 15 12 11 10 9 5 Total 256 178 191 163 174 160 133 181 151 142 126 103 Pancreas/ Kidney 18 Pancreas after kidney 5 Pancreas alone State Pancreas/ Kidney Pancreas after kidney Pancreas alone Total SP 48 15 3 66 PR 19 0 2 21 MG 18 1 0 20 SC 5 2 0 7 PE 5 0 0 5 CE 5 0 0 5 GO 3 0 0 3 103 18 5 126 number of transplant 60 40 20 0 Pancreas alone Pancreas after kidney Pancreas/Kidney SP PR MG SC PE CE GO Survival Curve: Registry set up on 2010-01-01 (Pancreas/Kidney) Number of transplants per million population by state during the year 2014 2.5 1.0 0.8 0.6 0.4 0.2 0.0 82% Patient 78% Kidney 76% Pancreas Active Reported 100% Transplant Teams 27 17 (63%) Transplants 559 482 (86%) 0 1 2 3 4 5 years Cumulative survival include data from transplant teams who reported 100% of their results during the period State Pancreas/ Kidney Pancreas after kidney Pancreas alone Total PR 1.8 0.0 0.2 2.0 SP 1.2 0.4 0.1 1.6 SC 0.8 0.3 0.0 1.1 MG 0.9 0.1 0.0 1.0 CE 0.6 0.0 0.0 0.6 PE 0.6 0.0 0.0 0.6 GO 0.5 0.0 0.0 0.5 0.5 0.1 0.0 0.7 number of transplants per million population 2.0 1.5 1.0 0.5 Pancreas alone Pancreas after kidney Pancreas/Kidney 0.0 PR SP SC MG CE PE GO 12

Annual number of transplants in between 2004 and 2014 Lung - (in 4 states, with 6 active teams) 80 Annual number in Number of transplants by state during the year 2014 66 Deceased 40 60 number of transplant 40 20 41 Bilateral 25 Unilateral number of transplant 30 20 deceased donor living donor 1 Living 0 2004 2005 2006 Deceased 41 42 45 45 52 58 60 48 68 76 66 Bilateral 10 8 14 14 24 23 37 24 41 40 41 Unilateral 28 29 26 27 26 34 23 24 27 36 25 Living 5 3 4 1 1 1 1 1 1 4 1 Total 46 45 49 46 53 59 61 49 69 80 67 State Living Deceased Total SP 0 33 33 RS 1 21 22 CE 0 11 11 MG 0 1 1 1 66 67 10 0 SP RS CE MG Survival Curve: Registry set up on 2010-01-01 Number of transplants per million population by state during the year 2014 2.5 1.0 0.8 0.6 0.4 0.2 51 % Patient Active Reported 100% Transplant Teams 7 6 (86%) Transplants 326 318 (98%) 0.0 0 1 2 3 4 5 Years Cumulative survival include data from transplant teams who reported 100% of their results during the period number of transplants per million population State Living Deceased Total RS 0.1 2.0 2.1 CE 0.0 1.3 1.3 SP 0.0 0.8 0.8 MG 0.0 0.1 0.1 0.0 0.3 0.4 2.0 1.5 1.0 0.5 0 deceased donor living donor RS CE SP MG 13

Annual number of transplants in between 2004 and 2014 Bone Marrow - (in 11 states, with 53 active teams) Number of Bone Marrow transplants by state during the year 2014 1000 25000 20000 Annual number of tissue and Bone Marrow transplants 21,681 - Bone state Allogeneic Autologous Total SP 386 538 924 PE 81 133 214 PR 136 62 198 RJ 41 144 185 MG 36 77 113 SC 0 87 87 RS 48 38 86 CE 4 58 62 DF 0 56 56 BA 6 48 54 ES 0 34 34 738 1275 2013 number of transplant 800 600 400 200 0 Autologous Allogeneic SP PE PR RJ MG SC RS CE DF BA ES number of transplant 15000 10000 13,036 Cornea 5000 2,013 Bone Marrow 28 - Skin 0 2004 2005 2006 Bone 724 755 1,996 2,340 5,521 22,503 23,647 23,815 23,211 23,348 21,681 Cornea 6,670 8,713 10,124 9,040 13,341 12,723 12,778 14,696 15,281 13,744 13,036 Bone Marrow 1,239 1,217 1,420 1,459 1,494 1,543 1,659 1,747 1,753 1,813 2,013 Skin 0 0 0 1 0 17 26 21 30 23 28 Number of Bone Marrow Transplants per million population by state during the year 2014 30 Tissue and Bone Marrow transplants per million population 140 120 state Allogeneic Autologous Total PE 9.2 15.1 24.3 SP 9.4 13.0 22.4 DF 0.0 21.8 21.8 PR 13.0 5.9 19.0 SC 0.0 13.9 13.9 RJ 2.6 9.0 11.6 ES 0.0 9.7 9.7 RS 4.5 3.6 8.0 CE 0.5 6.9 7.3 MG 1.8 3.9 5.8 BA 0.4 3.4 3.9 3.9 6.7 10.6 number of transplants per million population 25 Autologous 20 Allogeneic 15 10 5 0 PE SP DF PR SC RJ ES RS CE MG BA number of transplants per million population 113.7 Bone 100 80 60 68.3 Cornea 40 20 10.6 Bone Marrow 0.1 Skin 0 2004 2005 2006 Bone 4.0 4.1 10.8 12.7 30.0 118.5 123.3 124.8 121.7 122.4 113.7 Cornea 36.7 51.3 59.6 49.1 72.5 69.2 67.0 77.0 80.1 72.1 68.3 Bone Marrow 7.3 7.2 8.4 7.9 8.1 8.4 8.7 9.2 9.2 9.5 10.6 Skin 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.1 0.1 14

Annual number of transplants in between 2004 and 2014 Number of cornea transplants by state during the year 2014 5000 CORNEA - (in 24 state) BONE- (in 4 state) Number of bone transplants data available from six tissue banks in four states, during the year 2014 State Total SP 4,273 MG 1,419 PR 811 CE 786 PE 759 GO 735 SC 729 RS 710 DF 351 BA 332 ES 308 RJ 301 PA 212 PI 195 AM 187 RN 159 PB 140 MS 139 SE 129 MT 116 MA 107 AL 90 AC 25 RO 23 13,036 4000 3000 2000 1000 0 SP MG PR CE PE GO SC RS DF BA ES RJ PA PI AM RN PB MS SE MTMA AL AC RO 20000 15000 10000 5000 Homologous Dentistry Homologous Orthopaedic Autologous Other Autologous Orthopaedic Homologous Other Autologous Dentistry 0 SP PR RJ PE Orthopaedic Dentistry Others Homologous Autologous Homologous Autologous Homologous Autologous Total SP 846 1 19281 0 0 11 20139 RJ 677 1 115 0 0 18 811 RS 151 0 575 0 0 0 726 PE 5 0 0 0 0 0 5 1679 2 19971 0 0 29 21681 Number of cornea transplants per million population during the year 2014 150 Bone Transplants per million population data available from six tissue banks in four states, during the year 2014 600 State Total DF 136.6 GO 122.4 SC 116.7 SP 103.6 CE 93.0 ES 87.6 PE 86.3 PR 77.6 MG 72.4 RS 66.4 PI 62.5 SE 62.4 MS 56.8 AM 53.7 RN 50.2 MT 38.2 PB 37.2 AC 34.1 AL 28.8 PA 28.0 BA 23.7 RJ 18.8 MA 16.3 RO 14.7 68.3 120 90 60 30 0 DF GO SC SP CE ES PE PR MG RS PI SE MS AM RN MT PB AC AL PA BA RJ MA RO 500 400 300 200 100 Homologous Dentistry Homologous Orthopaedic Autologous Other Autologous Orthopaedic Homologous Other Autologous Dentistry 0 SP PR RJ PE Orthopaedic Dentistry Others Homologous Autologous Homologous Autologous Homologous Autologous Total SP 20.5 0.0 467.3 0.0 0.0 0.3 488.1 RS 14.1 0.0 53.8 0.0 0.0 0.0 67.9 RJ 42.3 0.1 7.2 0.0 0.0 1.1 50.7 PE 0.6 0.0 0.0 0.0 0.0 0.0 0.6 8.8 0.0 104.7 0.0 0.0 0.2 113.7 number of transplants number of transplant number of transplants per million population number of transplants per million population 15

PEDIATRIC TRANSPLANTATION A small increment (4.3%) in the number of pediatric transplants was reached in 2014. Heart and lung transplants still have very low numbers and that either decreased (heart) or kept stable (lungs) this year. In spite if the increment in the last years there is still a significant variation year by year. Pediatric kidney transplants with living donors are decreasing substantially since 2009, a 53% drop in the period. This is compensated by the increment in deceased donor transplants. The vast majority is still performed in the South and Southeast regions but some states in Northeast of (CE, PE and BA) have increased their transplant activity significantly. In spite of this it is possible to identify obstacles to the accesses to transplantation. Perhaps the most important are the long distances in the country, operational difficulties and poor interaction between dialysis and transplants centers. Other hurdles for pediatric kidney transplants are the suboptimal standard of care of chronic kidney disease in some regions of the country such as difficulty managing obstructive uropathy, poor anemia and vascular access management. We reinforce the need to expedite kidney transplantation as the treatment of choice in children, preferably preemptively. Liver transplants decreased in 2014 as compared to the previous year. An increment in the number of living donor transplants has been observed. This year for the first time the number of transplants with living donors (58%) was higher than the number with deceased donors EDITORIAL (42%). Similar to the pediatric kidney transplants, access to pediatric liver transplantation has to be improved in the country. We remain optimistic and hope for a better 2015 in which, by education of the population and the efforts of authorities and medical societies, the difficulties in pediatric transplantation can be eliminated. Coming together is a beginning, keeping together is progress, working together is success. (Henry Ford) CLOTILDE DRUCK GARCIA LILIAN MONTEIRO PEREIRA VIVIANE DE BARROS BITTENCOURT Number of pediatric transplants, during 2014 Organ Living Deceased Total PMP Teams Heart 0 35 35 0.6 9 Liver 110 80 190 3.4 27 Lung 1 3 4 0.1 2 Kidney 50 299 349 6.2 53 Total 161 417 578 ---- 91 Annual number of pediatric kidney transplants 350 Annual number of pediatric liver transplants 150 280 299 decesead 120 110 living 99 related 210 90 80 decesead 140 60 70 0 2009 2010 2011 2012 2013 2014 Deceased 175 187 191 329 251 299 Living 120 112 95 48 59 50 Related 120 111 94 47 58 50 Unrelated 0 1 1 1 1 0 Total 295 299 286 377 310 349 50 living 50 related 0 unrelated 30 0 2009 2010 2011 2012 2013 2014 Deceased 125 88 120 102 95 80 Living 77 75 79 85 109 110 Related 73 70 73 81 106 99 Unrelated 4 5 6 4 3 11 Total 202 163 199 187 204 190 11 unrelated 16

PEDIATRIC TRANSPLANTATION Number of transplants per state during the year 2014 160 Kidney Number of transplants per state during the year 2014 160 Liver state Living Deceased Total 120 SP 24 132 156 RS 3 40 43 PR 6 22 28 CE 0 23 23 MG 1 21 22 RJ 1 18 19 PE 3 11 14 BA 4 8 12 DF 2 4 6 PA 0 6 6 GO 0 5 5 RN 3 2 5 ES 1 2 3 AM 0 2 2 PB 2 0 2 SC 0 2 2 AC 0 1 1 50 299 349 80 40 0 SP RS PR CE MG RJ deceased donor living donor PE BA DF PA GO RN ES AM PB SC AC state Living Deceased Total SP 93 49 142 RS 8 4 12 PR 4 6 10 RJ 5 3 8 MG 0 7 7 CE 0 4 4 PE 0 4 4 BA 0 1 1 DF 0 1 1 SC 0 1 1 110 80 190 120 80 40 0 deceased donor living donor SP RS PR RJ MG CE PE BA DF SC Transplants pmp per state in 2014 Transplants pmp per state in 2014 16 16 state Living Deceased Total RS 1.1 14.5 15.6 SP 2.2 12.2 14.4 PR 2.0 7.4 9.5 CE 0.0 8.5 8.5 DF 2.7 5.4 8.1 RN 3.1 2.1 5.2 PE 1.1 4.0 5.1 RJ 0.2 4.3 4.6 MG 0.2 3.9 4.0 AC 0.0 3.4 3.4 ES 1.0 2.0 3.0 GO 0.0 2.8 2.8 BA 0.9 1.8 2.7 PA 0.0 2.1 2.1 PB 1.7 0.0 1.7 AM 0.0 1.4 1.4 SC 0.0 1.2 1.2 0.9 5.3 6.2 12 8 Falecido Vivo deceased donor living donor state Living Deceased Total SP 8.6 4.5 13.1 RS 2.9 1.4 4.3 deceased donor PR 1.4 2.0 3.4 RJ 1.2 0.7 1.9 living donor 4 CE 0.0 1.5 1.5 4 PE 0.0 1.5 1.5 DF 0.0 1.4 1.4 MG 0.0 1.3 1.3 SC 0.0 0.6 0.6 BA 0.0 0.2 0.2 0 2.0 1.4 3.4 0 RS SP PR CE DF RN PE RJ MG AC ES GO BA PA PB AM SC SP RS PR RJ CE PE DF MG SC BA 12 8 17

DATA FROM BRAZILIAN REGIONS GENERAL DATA The North: 15.8 million people Effective donors: 3.3 pmp Transplants Performed: Cornea 28.2 pmp Kidney 5.7 pmp Liver 0.4 pmp Pancreas 0.0 pmp Heart 0.0 pmp Lung 0.0 pmp : 190.8 million people Effective donors: 14.2 pmp Transplants Performed: Cornea 68.3 pmp Kidney 29.6 pmp Liver 9.2 pmp Pancreas 0.7 pmp Heart 1.6 pmp Lung 0.4 pmp The Northeast: 53.1 million people Effective donors: 10.7 pmp Transplants Performed: Cornea 50.8 pmp Kidney 15.9 pmp Liver 6.9 pmp Pancreas 0.2 pmp Heart 0.9 pmp Lung 0.2 pmp The Midwest: 14.1 million people Effective donors: 8.2 pmp Transplants Performed: Cornea 95.4 pmp Kidney 11.8 pmp Liver 3.8 pmp Pancreas 0.2 pmp Heart 1.8 pmp Lung 0.0 pmp The South: 27.3 million people Effective donors: 21.5 pmp Transplants Performed: Cornea 82.2 pmp Kidney 46.7 pmp Liver 12.9 pmp Pancreas 1.0 pmp Heart 1.6 pmp Lung 0.8 pmp The Southeast: 80.3 million people Effective donors: 17.3 pmp Transplants Performed: Cornea 78.7 pmp Kidney 40.4 pmp Liver 12.1 pmp Pancreas 1.1 pmp Heart 2.4 pmp Lung 0.4 pmp POPULATION The Midwest 13,222,854 13,222,854 13,222,854 14,058,094 14,058,094 14,058,094 14,058,094 14,058,094 The Northeast 51,534,406 51,534,406 51,534,406 53,081,950 53,081,950 53,081,950 53,081,950 53,081,950 The North 14,623,316 14,623,316 14,623,316 15,864,454 15,864,454 15,864,454 15,864,454 15,864,454 The Southeast 77,873,120 77,873,120 77,873,120 80,364,410 80,364,410 80,364,410 80,364,410 80,364,410 The South 26,733,595 26,733,595 26,733,595 27,386,891 27,386,891 27,386,891 27,386,891 27,386,891 18

DATA FROM BRAZILIAN REGIONS ORGAN DONATION Notified potential donors - pmp Effective donors - pmp The Midwest The Northeast The North The Southeast The South Number of potential donors by year Absolute numbers The Midwest 466 484 508 544 589 671 789 807 The Northeast 1,005 1,139 1,241 1,509 1,589 1,948 2,102 2,298 The North 115 102 143 112 175 319 378 384 The Southeast 2,955 3,343 3,593 3,781 3,673 3,718 4,010 4,219 The South 953 924 1,005 1,033 1,212 1,369 1,592 1,643 Number pmp The Midwest 35.2 36.6 38.4 38.7 41.9 47.7 56.1 57.4 The Northeast 19.5 22.1 24.1 28.4 29.9 36.7 39.6 43.3 The North 7.9 7.0 9.8 7.1 11.0 20.1 23.8 24.2 The Southeast 37.9 42.9 46.1 47.0 45.7 46.3 49.9 52.5 The South 35.6 34.6 37.6 37.7 44.3 50.0 58.1 60.0 Number of effective donors by year Absolute numbers The Midwest 46 47 75 72 72 98 124 115 The Northeast 199 227 269 321 367 466 489 569 The North 8 9 16 11 37 58 53 53 The Southeast 585 738 961 1,159 1,143 1,274 1,298 1,387 The South 312 296 337 335 429 510 562 589 Number pmp The Midwest 3.5 3.6 5.7 5.1 5.1 7.0 8.8 8.2 The Northeast 3.9 4.4 5.2 6.0 6.9 8.8 9.2 10.7 The North 0.5 0.6 1.1 0.7 2.3 3.7 3.3 3.3 The Southeast 7.5 9.5 12.3 14.4 14.2 15.9 16.2 17.3 The South 11.7 11.1 12.6 12.2 15.7 18.6 20.5 21.5 TISSUE TRANSPLANTS Cornea - pmp The Midwest The Northeast The North The Southeast The South CORNEA Absolute numbers 9,040 13,341 12,723 12,778 14,696 15,281 13,744 13,036 The Midwest 951 1,103 1,091 1,018 1,620 1,811 1,377 1,341 The Northeast 1,597 1,826 2,114 1,977 2,651 3,087 2,883 2,697 The North 178 194 230 294 287 481 438 447 The Southeast 5,191 8,377 7,320 7,398 7,557 7,534 7,022 6,321 The South 1,123 1,841 1,968 2,091 2,581 2,368 2,024 2,250 Number pmp 49.1 72.5 69.2 67.0 77.0 80.1 72.1 68.3 The Midwest 71.9 83.4 82.5 72.4 115.2 128.8 98.0 95.4 The Northeast 31.0 35.4 41.0 37.2 49.9 58.2 54.3 50.8 The North 12.2 13.3 15.7 18.5 18.1 30.3 27.6 28.2 The Southeast 66.7 107.6 94.0 92.1 94.0 93.7 87.4 78.7 The South 42.0 68.9 73.6 76.4 94.2 86.5 73.9 82.2 19

Kidney from deceased donor - pmp DATA FROM BRAZILIAN REGIONS Organ Transplantation Kidney from living donor - pmp The Midwest The Northeast The North The Southeast The South Kidney (living donor) Absolute numbers 1,713 1,780 1,742 1,655 1,650 1,499 1,382 1,384 The Midwest 62 75 67 81 81 76 68 32 The Northeast 180 210 194 203 187 153 124 132 The North 34 27 29 47 33 37 33 27 The Southeast 1,094 1,121 1,108 966 990 922 872 903 The South 343 347 344 358 359 311 285 290 Number pmp 9.3 9.7 9.5 8.7 8.6 7.9 7.2 7.3 The Midwest 4.7 5.7 5.1 5.8 5.8 5.4 4.8 2.3 The Northeast 3.5 4.1 3.8 3.8 3.5 2.9 2.3 2.5 The North 2.3 1.8 2.0 3.0 2.1 2.3 2.1 1.7 The Southeast 14.0 14.4 14.2 12.0 12.3 11.5 10.9 11.2 The South 12.8 13.0 12.9 13.1 13.1 11.4 10.4 10.6 Kidney (deceased donor) Absolute numbers 1,749 2,035 2,543 3,001 3,325 3,914 4,065 4,255 The Midwest 46 73 89 88 97 143 177 133 The Northeast 294 330 417 479 532 698 731 715 The North 12 15 18 24 68 91 69 64 The Southeast 910 1,125 1,446 1,842 1,865 2,065 2,108 2,353 The South 487 492 573 568 763 917 980 990 Number pmp 9.5 11.1 13.8 15.7 17.4 20.5 21.3 22.3 The Midwest 3.5 5.5 6.7 6.3 6.9 10.2 12.6 9.5 The Northeast 5.7 6.4 8.1 9.0 10.0 13.1 13.8 13.5 The North 0.8 1.0 1.2 1.5 4.3 5.7 4.3 4.0 The Southeast 11.7 14.4 18.6 22.9 23.2 25.7 26.2 29.3 The South 18.2 18.4 21.4 20.7 27.9 33.5 35.8 36.1 Liver - pmp The Midwest The Northeast The North The Southeast The South 20 LIVER Absolute numbers 1,008 1,177 1,334 1,413 1,496 1,598 1,723 1,755 The Midwest 0 0 0 0 0 39 53 54 The Northeast 156 201 208 244 316 351 388 366 The North 0 0 0 0 0 0 1 7 The Southeast 605 721 859 926 872 882 909 974 The South 247 255 267 243 308 326 372 354 Number pmp 5.5 6.4 7.3 7.4 7.8 8.4 9.0 9.2 The Midwest 0.0 0.0 0.0 0.0 0.0 2.8 3.8 3.8 The Northeast 3.0 3.9 4.0 4.6 6.0 6.6 7.3 6.9 The North 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 The Southeast 7.8 9.3 11.0 11.5 10.9 11.0 11.3 12.1 The South 9.2 9.5 10.0 8.9 11.2 11.9 13.6 12.9

DATA FROM BRAZILIAN REGIONS Pancreas - pmp The Midwest The Northeast The North The Southeast The South PANCREAS Absolute numbers 163 174 160 133 181 151 142 126 The Midwest 0 1 0 0 0 6 2 3 The Northeast 0 0 1 6 10 15 13 10 The North 0 0 0 0 0 0 0 0 The Southeast 125 131 141 112 136 107 92 85 The South 38 42 18 15 35 23 35 28 Number pmp 0.9 0.9 0.9 0.7 0.9 0.8 0.7 0.7 The Midwest 0.0 0.1 0.0 0.0 0.0 0.4 0.1 0.2 The Northeast 0.0 0.0 0.0 0.1 0.2 0.3 0.2 0.2 The North 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 The Southeast 1.6 1.7 1.8 1.4 1.7 1.3 1.1 1.1 The South 1.4 1.6 0.7 0.5 1.3 0.8 1.3 1.0 Heart - pmp The Midwest The Northeast The North The Southeast The South HEART Absolute numbers 161 201 201 166 160 228 271 311 The Midwest 3 2 9 4 9 18 32 25 The Northeast 32 42 39 28 33 47 57 49 The North 1 0 0 0 0 0 0 0 The Southeast 71 107 120 114 89 126 143 192 The South 54 50 33 20 29 37 39 45 Number pmp 0.9 1.1 1.1 0.9 0.8 1.2 1.4 1.6 The Midwest 0.2 0.2 0.7 0.3 0.6 1.3 2.3 1.8 The Northeast 0.6 0.8 0.8 0.5 0.6 0.9 1.1 0.9 The North 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 The Southeast 0.9 1.4 1.5 1.4 1.1 1.6 1.8 2.4 The South 2.0 1.9 1.2 0.7 1.1 1.4 1.4 1.6 Lung - pmp The Midwest The Northeast The North The Southeast The South LUNG Absolute numbers 46 53 59 61 49 69 80 67 The Midwest 0 0 0 0 0 0 2 0 The Northeast 0 0 0 0 4 4 8 11 The North 0 0 0 0 0 0 0 0 The Southeast 20 26 18 33 18 32 39 34 The South 26 27 41 28 27 33 31 22 Number pmp 0.3 0.3 0.3 0.3 0.3 0.4 0.4 0.4 The Midwest 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 The Northeast 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.2 The North 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 The Southeast 0.3 0.3 0.2 0.4 0.2 0.4 0.5 0.4 The South 1.0 1.0 1.5 1.0 1.0 1.2 1.1 0.8 21

Number of potential donors by state State Total SP 2434 RJ CE 973 624 2500 MG 617 RS 604 PR 570 PE SC 564 469 2000 BA 455 DF 336 GO 260 ES RN 195 174 1500 MS 166 PB 161 PA 129 AM SE 126 110 1000 MA 90 PI 79 RO 70 AC MT 59 45 500 AL 41 AP 0 RR 0 TO 0 0 9351 SP RJ CE MG RS PR PE SC BA DF GO ES RN MS PB PA AM SE MA PI RO AC MT AL AP RR TO number of potencial donors DATA FROM INDIVIDUAL STATES Active Patients on the waiting list (december 2014) State Kidney Liver Heart Lung Pancreas Pancreas/ Kidney Cornea Total - 18,147 1,304 247 204 19 446 8,602 Acre 7 6 NI NI NI NI 5 Alagoas 153 NI 2 NI NI NI 95 Amazonas 9 6 NI NI NI NI 269 Bahia 422 45 NI NI NI NI 1,042 Ceará 525 93 7 3 2 NI 454 Distrito Federal 193 24 15 0 0 0 157 Espírito Santo 762 28 1 0 0 0 81 Goiás 332 0 1 0 0 6 734 Maranhão 129 NI NI NI NI NI 739 Mato Grosso NI NI NI NI NI NI 152 Mato Grosso do Sul 18 NI 16 NI NI NI 22 Minas Gerais 2,542 18 33 12 0 38 64 Pará 66 NI NI NI NI NI 871 Paraíba 148 1 0 0 0 0 216 Paraná 1,244 83 39 0 3 10 45 Pernambuco 462 45 4 0 0 1 1 Piauí 111 NI NI NI NI NI 350 Rio de Janeiro 811 143 11 0 0 0 1,280 Rio Grande do Norte 118 0 0 0 0 0 43 Rio Grande do Sul 887 141 17 80 0 4 21 Rondonia 17 0 0 0 0 0 29 Santa Catarina 281 27 1 NI 0 12 213 São Paulo 8,910 644 100 109 14 375 1,651 Sergipe NI NI NI NI NI NI 68 Organ donation during 2014 State Total SP 824 RJ 272 MG 245 CE 220 RS 214 SC 202 PR 173 PE 145 BA 109 DF 75 ES 46 RN 43 GO 26 AM 20 PA 18 PI 17 MS 14 RO 10 PB 10 SE 9 AL 9 MA 7 AC 5 MT 0 AP 0 RR 0 TO 0 2713 nnumber of effective donors 1000 750 500 250 Absolute number of effective donors by state 0 SP RJ MG CE RS SC PR PE BA DF ES RN GO AM PA PI MS RO PB SE AL MA AC MT AP RR TO State Total DF 130.7 AC 80.4 SC 75.1 CE 73.8 MS 67.8 PE 64.1 RJ 60.9 SP 59.0 RS 56.5 ES 55.5 RN 54.9 PR 54.6 SE 53.2 RO 44.8 GO 43.3 PB 42.7 AM 36.2 BA 32.5 MG 31.5 PI 25.3 PA 17.0 MT 14.8 MA 13.7 AL 13.1 AP 0.0 RR 0.0 TO 0.0 49.0 number per million population Number of potential donors per million population 150 120 90 60 30 0 DF AC SC CE MS PE RJ SP RS ES RN PR SE RO GO PB AM BA MG PI PA MT MA AL AP RR TO State Total SC 32.3 DF 29.2 CE 26.0 RS 20.0 SP 20.0 RJ 17.0 PR 16.6 PE 16.5 RN 13.6 ES 13.1 MG 12.5 BA 7.8 AC 6.8 RO 6.4 AM 5.7 MS 5.7 PI 5.5 SE 4.4 GO 4.3 AL 2.9 PB 2.7 PA 2.4 MA 1.1 MT 0.0 AP 0.0 RR 0.0 TO 0.0 14.2 number per million population Number of effective donors per million population 35 30 25 20 15 10 5 0 SC DF CE RS SP RJ PR PE RN ES MG BA AC ROAMMS PI SE GO AL PB PA MA MT AP RR TO 22

Number of notifications of potential donors, effective donors and donors whose organs were transplanted by state during the year 2014 State DATA FROM INDIVIDUAL STATES Notifications (potential donors) Nº pmp/ year Refused Donors Effective donors Nº % Nº pmp/ year Donors whose organs were transplanted Nº pmp/ year Mutiple Organ Donors Nº % Total - 9,351 49.0 6638 (71%) 2,713 14.2 2,508 13.1 1,684 (67%) Acre 59 80.4 54 (92%) 5 6.8 5 6.8 4 (80%) Alagoas 41 13.1 32 (78%) 9 2.9 9 2.9 3 (33%) Amapá 0 0.0 0 (0%) 0 0.0 0 0.0 0 (0%) Amazonas 126 36.2 106 (84%) 20 5.7 20 5.7 11 (55%) Bahia 455 32.5 346 (76%) 109 7.8 83 5.9 77 (93%) Ceará 624 73.8 404 (65%) 220 26.0 215 25.4 167 (78%) Distrito Federal 336 130.7 261 (78%) 75 29.2 50 19.5 31 (62%) Espírito Santo 195 55.5 149 (76%) 46 13.1 40 11.4 35 (88%) Goiás 260 43.3 234 (90%) 26 4.3 26 4.3 16 (62%) Maranhão 90 13.7 83 (92%) 7 1.1 6 0.9 0 (0%) Mato Grosso 45 14.8 45 (100%) 0 0.0 0 0.0 0 (0%) Mato Grosso do Sul 166 67.8 152 (92%) 14 5.7 14 5.7 12 (86%) Minas Gerais 617 31.5 372 (60%) 245 12.5 231 11.8 219 (95%) Pará 129 17.0 111 (86%) 18 2.4 17 2.2 15 (88%) Paraíba 161 42.7 151 (94%) 10 2.7 10 2.7 4 (40%) Paraná 570 54.6 397 (70%) 173 16.6 159 15.2 101 (64%) Pernambuco 564 64.1 419 (74%) 145 16.5 133 15.1 83 (62%) Piauí 79 25.3 62 (78%) 17 5.5 16 5.1 9 (56%) Rio de Janeiro 973 60.9 701 (72%) 272 17.0 234 14.6 130 (56%) Rio Grande do Norte 174 54.9 131 (75%) 43 13.6 43 13.6 36 (84%) Rio Grande do Sul 604 56.5 390 (65%) 214 20.0 179 16.7 112 (63%) Rondonia 70 44.8 60 (86%) 10 6.4 9 5.8 1 (0%) Roraima 0 0.0 0 (0%) 0 0.0 0 0.0 0 (0%) Santa Catarina 469 75.1 267 (57%) 202 32.3 192 30.7 148 (77%) São Paulo 2434 59.0 1610 (66%) 824 20.0 810 19.6 463 (57%) Sergipe 110 53.2 101 (92%) 9 4.4 7 3.4 7 (0%) Tocantins 0 0.0 0 (0%) 0 0.0 0 0.0 0 (0%) Percentage of donor effectiveness in relation to the number of notifications 23

DATA FROM INDIVIDUAL STATES Reasons for non-fulfillment of organ donation by notified potential donors during the year 2014 Exclusion Reasons State Potential Donors Family Interview Medical Contraindication Cardiopulmonary Arrest Others accomplished nonconsent % Nº % Nº % Nº % Total - 9351 5727 2610 (46%) 1349 (14%) 1156 (12%) 1523 (16%) Acre 59 26 19 (73%) 14 (24%) 0 (0%) 21 (36%) Alagoas 41 16 5 (31%) 6 (15%) 0 (0%) 21 (51%) Amapá 0 0 0 (0%) 0 (0%) 0 (0%) 0 (0%) Amazonas 126 64 42 (66%) 12 (10%) 0 (0%) 52 (41%) Bahia 455 285 176 (62%) 42 (9%) 27 (6%) 101 (22%) Ceará 624 416 187 (45%) 108 (17%) 95 (15%) 14 (2%) Distrito Federal 336 157 75 (48%) 163 (49%) 1 (0%) 22 (7%) Espírito Santo 195 96 48 (50%) 32 (16%) 2 (1%) 67 (34%) Goiás 260 127 104 (82%) 26 (10%) 10 (4%) 94 (36%) Maranhão 90 23 13 (57%) 25 (28%) 1 (1%) 44 (49%) Mato Grosso 45 0 0 (0%) 0 (0%) 0 (0%) 45 (100%) Mato Grosso do Sul 166 58 42 (72%) 79 (48%) 20 (12%) 11 (7%) Minas Gerais 617 344 152 (44%) 41 (7%) 79 (13%) 100 (16%) Pará 129 73 40 (55%) 23 (18%) 22 (17%) 26 (20%) Paraíba 161 44 28 (64%) 20 (12%) 3 (2%) 100 (62%) Paraná 570 340 153 (45%) 151 (26%) 93 (16%) 0 (0%) Pernambuco 564 346 189 (55%) 145 (26%) 14 (2%) 71 (13%) Piauí 79 47 30 (64%) 18 (23%) 7 (9%) 7 (9%) Rio de Janeiro 973 490 216 (44%) 189 (19%) 200 (21%) 96 (10%) Rio Grande do Norte 174 120 68 (57%) 19 (11%) 7 (4%) 37 (21%) Rio Grande do Sul 604 422 184 (44%) 80 (13%) 114 (19%) 12 (2%) Rondonia 70 28 17 (61%) 1 (1%) 0 (0%) 42 (60%) Roraima 0 0 0 (0%) 0 (0%) 0 (0%) 0 (0%) Santa Catarina 469 363 134 (37%) 56 (12%) 58 (12%) 19 (4%) São Paulo 2434 1784 643 (36%) 74 (3%) 401 (16%) 492 (20%) Sergipe 110 58 45 (78%) 25 (23%) 2 (2%) 29 (26%) Tocatins 0 0 0 (0%) 0 (0%) 0 (0%) 0 (0%) 24

DATA FROM INDIVIDUAL STATES Profile: age, gender, cause of death and blood group of the organ donors State Gender Causes of death Age Blood group Masc Fem BT* CVA Others 5 6-10 11-17 18-34 35-49 50-64 65 A AB B O TOTAL - 1621 1092 1033 1313 367 54 39 155 688 747 798 232 1009 101 279 1324 Percentage 60% 40% 38% 48% 14% 2% 1% 6% 25% 28% 29% 9% 37% 4% 10% 49% Acre 4 1 3 2 0 0 0 0 2 2 1 0 3 0 0 2 Alagoas 7 2 5 2 2 1 0 0 4 1 3 0 2 0 1 6 Amapa 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Amazonas 12 8 8 11 1 0 2 1 6 5 4 2 6 0 1 13 Bahia 59 50 45 52 12 2 1 6 33 36 25 6 44 3 9 53 Ceará 142 78 102 101 17 2 3 18 65 53 55 24 75 8 22 115 Distrito Federal 50 25 34 21 20 5 2 6 21 20 18 3 32 2 10 31 Espírito Santo 25 21 25 19 2 0 0 4 15 16 10 1 20 1 5 20 Goiás 19 7 17 9 0 0 0 2 10 7 6 1 6 1 3 16 Maranhão 4 3 1 3 3 0 0 0 3 2 2 0 0 0 1 6 Mato Grosso 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Mato Grosso do Sul 9 5 5 1 8 0 0 1 5 4 2 2 3 1 1 9 Minas Gerais 134 111 97 116 32 3 2 17 54 77 80 12 79 15 37 114 Pará 15 3 10 6 2 0 0 3 10 3 2 0 4 0 1 13 Paraíba 8 2 6 2 2 0 0 1 3 4 2 0 5 0 1 4 Paraná 113 60 48 71 54 3 3 8 45 40 54 20 55 9 19 90 Pernambuco 90 55 47 83 15 3 0 3 32 43 50 14 46 10 18 71 Piauí 10 7 8 6 3 0 1 2 9 3 1 1 3 1 2 11 Rio de Janeiro 155 117 97 140 35 3 5 10 89 60 67 38 97 7 34 134 Rio Grande do Norte 22 21 20 17 6 2 0 1 12 14 12 2 17 1 4 21 Rio Grande do Sul 121 93 62 123 29 3 3 13 45 52 66 32 90 8 16 100 Rondonia 4 6 2 6 2 0 0 0 1 2 6 1 7 0 0 3 Roraima 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Santa Catarina 120 82 77 104 21 2 3 9 42 56 73 17 80 8 11 103 São Paulo 492 332 307 416 101 25 14 50 178 245 256 56 332 26 83 383 Sergipe 6 3 7 2 0 0 0 0 4 2 3 0 3 0 0 6 Tocantins 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 BT* Brain Trauma 25

ACRE Population 733,559 (0.4%) Capital City: Rio Branco 336,038 Area (Km²) 152,581.39 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 66 44 18 4 Performed transplants 25 8 4 0 Number of Mortality per year All Causes 2,799 2,858 2,892 3,009 3,157 3,293 Unavailable Unavailable External Causes 357 355 387 439 488 531 Unavailable Unavailable Neurological Causes 35 48 58 50 43 57 Unavailable Unavailable Population (census IBGE) 655,385 655,385 655,385 733,559 733,559 733,559 733,559 733,559 HOSPITALS % Nº Total 22 (0.4) State s capital 9 Country side 13 Nº of beds 1,394 (0.3) Nº of ICU beds 74 (0.2) Hospitals over 80 beds 5 Teaching hospitals 0 Medical schools 2 (0.9) Neurosurgery services 3 (0.7) Number of CIHDOTTS 4 Number of OPOs 1 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 CNCDO: Regiane Clélia Ferrari Phone: (68) 3227-6399 E-mail: cncdoacre@gmail.com Acre has the support of the local government for the development of the program but keeps on having low notification and high family refusal rates. Notified potential donors - pmp ORGAN DONATION Effective donors: - pmp North Acre Number of effective donors 0 0 4 2 4 4 7 5 Number of effective donors (pmp) 0.0 0.0 6.1 2.7 5.5 5.5 9.5 6.8 Potential donors 0 0 19 15 11 51 78 59 Number of potential donors(pmp) 0.0 0.0 29.0 20.4 15.0 69.5 106.3 80.4 Non consenting families 0 0 6 4 3 21 29 19 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 78 76 73 Cardiopulmonary Arrest Unavailable 2 2 0 0 3 0 Medical Contraindications 0 0 6 5 1 5 16 14 Others 0 0 1 2 3 21 23 21 26

ACRE Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp North Acre Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year Cornea Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Kidney 1 1 0 1 1 1 1 1 Liver 0 0 0 0 0 0 0 1 Pancreas (not performed) Heart (not performed) Lung (not performed) Absolute number of transplants Cornea 0 0 0 34 18 37 18 25 Kidney 4 2 0 12 14 9 8 8 living donor 4 2 0 10 6 3 4 3 deceased donor 0 0 0 2 8 6 4 5 Liver 0 0 0 0 0 0 0 4 Pancreas (not performed) Heart (not performed) Lung (not performed) Number of transplants pmp Cornea 0.0 0.0 0.0 46.3 24.5 50.4 24.5 34.1 Kidney 6.1 3.1 0.0 16.4 19.1 12.3 10.9 10.9 living donor 6.1 3.1 0.0 13.6 8.2 4.1 5.5 4.1 deceased donor 0.0 0.0 0.0 2.7 10.9 8.2 5.5 6.8 Liver 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.5 Pancreas (not performed) Heart (not performed) Lung (not performed) 27

ALAGOAS Population 3,120,494 (1.6%) Capital City: Maceió 932,748 Area (Km²) 27,767.66 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 281 187 78 19 Performed transplants 90 26 0 3 Number of Mortality per year All Causes 16,594 16,403 17,056 17,737 18,645 18,376 Unavailable Unavailable External Causes 2,984 2,956 3,060 3,403 3,572 3,367 Unavailable Unavailable Neurological Causes 182 190 194 169 197 240 Unavailable Unavailable Population (census IBGE) 3,037,103 3,037,103 3,037,103 3,120,494 3,120,494 3,120,494 3,120,494 3,120,494 HOSPITALS % Nº Total 71 (1.2) State s capital 40 Country side 31 Nº of beds 5,829 (1.2) Nº of ICU beds 428 (1.1) Hospitals over 80 beds 24 Teaching hospitals 0 Medical schools 4 (1.8) Neurosurgery services 5 (1.2) Number of CIHDOTTS 2 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Kelly Karina de Araújo Brandão Phone/Fax: (82) 3376-8186 / (82) 3315-7440 E-mail: doevida@saude.al.gov.br Alagoas state has tripled its number of effective donors but keeps on having a very low number of donors in contrast to other states in the same region. ORGAN DONATION Effective donors: - pmp Northeast Alagoas Number of effective donors 2 4 4 4 3 1 3 9 Number of effective donors (pmp) 0.7 1.3 1.3 1.3 1.0 0.3 1.0 2.9 Potential donors 25 35 16 15 12 2 16 41 Number of potential donors(pmp) 8.2 11.5 5.3 4.8 3.8 0.6 5.1 13.1 Non consenting families 7 15 5 4 0 0 4 5 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 0 44 31 Cardiopulmonary Arrest Unavailable 2 1 0 0 0 0 0 Medical Contraindications 8 8 1 3 1 0 4 6 Others 8 6 5 4 8 1 5 21 28

ALAGOAS Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Northeast Alagoas Liver - pmp (not performed) CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 3 3 3 3 2 2 3 4 LIVER (not performed) PANCREAS (not performed) HEART 0 1 1 1 0 0 0 1 Absolute number of transplants CORNEA 2 51 82 64 113 54 52 90 KIDNEY - total 17 17 17 18 15 10 22 26 living donor 15 11 11 10 11 8 13 14 deceased donor 2 6 6 8 4 2 9 12 LIVER (not performed) PANCREAS (not performed) HEART 0 2 1 2 0 0 0 3 Number of transplants pmp CORNEA 0.7 16.8 27.0 20.5 36.2 17.3 16.7 28.8 KIDNEY - total 5.6 5.6 5.6 5.8 4.8 3.2 7.1 8.3 living donor 4.9 3.6 3.6 3.2 3.5 2.6 4.2 4.5 deceased donor 0.7 2.0 2.0 2.6 1.3 0.6 2.9 3.8 LIVER (not performed) PANCREAS (not performed) HEART 0.0 0.7 0.3 0.6 0.0 0.0 0.0 1.0 29

AMAPÁ Population 669,526 (0.4%) Capital City: Macapá 398,204 Area (Km²) 142,814.59 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 60 40 17 4 Performed transplants 0 0 0 0 Number of Mortality per year All Causes 1,886 2,113 2,140 2,172 2,495 2,601 Unavailable Unavailable External Causes 406 429 421 503 488 536 Unavailable Unavailable Neurological Causes 7 17 27 29 35 30 Unavailable Unavailable Population (census IBGE) 587,311 587,311 587,311 669,526 669,526 669,526 669,526 669,526 HOSPITALS % Nº Total 11 (0.2) State s capital 7 Country side 4 Nº of beds 906 (0.2) Nº of ICU beds 46 (0.1) Hospitals over 80 beds 5 Teaching hospitals 0 Medical schools 1 (0.5) Neurosurgery services 1 (0.2) Number of CIHDOTTS 0 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 CNCDO: Eduardo Monteiro Cardoso Phone: (96) 3212-6281 E-mail: cncdo@saude.ap.gov.br Amapá has not yet implemented organ procurement, allocation and transplantation services. ORGAN DONATION Notified potential donors - pmp (not performed) Effective donors: - pmp (not performed) North Amapá Number of effective donors Number of effective donors (pmp) Potential donors Number of potential donors(pmp) Non consenting families Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable Cardiopulmonary Arrest Unavailable Medical Contraindications Others 30

AMAPÁ Organ Transplantation Kidney from deceased donor - pmp (not performed) Kidney from living donor - pmp (not performed) North Amapá Liver - pmp (not performed) CORNEA- pmp (not performed) Number of teams that performed transplantations during the year 2007 2008 2009 2010 2011 2012 2013 2013 CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY (not performed) LIVER (not performed) PANCREAS (not performed) HEART (not performed) Absolute number of transplants CORNEA (not performed) KIDNEY - total (not performed) living donor deceased donor LIVER (not performed) PANCREAS (not performed) HEART (not performed) Number of transplants pmp CORNEA (not performed) KIDNEY - total (not performed) living donor deceased donor LIVER (not performed) PANCREAS (not performed) HEART (not performed) 31

AMAZONAS Population 3,483,985 (1.8%) Capital City: Manaus 1,802,014 Area (Km²) 1,570,745.68 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 314 209 87 21 Performed transplants 187 22 3 0 Number of Mortality per year All Causes 11,757 12,715 12,992 13,300 14,227 14,847 Unavailable Unavailable External Causes 1,681 1,948 1,991 2,263 2,527 2,678 Unavailable Unavailable Neurological Causes 120 179 159 168 170 221 Unavailable Unavailable Population (census IBGE) 3,221,939 3,221,939 3,221,939 3,483,985 3,483,985 3,483,985 3,483,985 3,483,985 HOSPITALS % Nº Total 108 (1.8) State s capital 47 Country side 61 Nº of beds 6,203 (1.3) Nº of ICU beds 478 (1.2) Hospitals over 80 beds 22 Teaching hospitals 1 Medical schools 3 (1.4) Neurosurgery services 4 (1.0) Number of CIHDOTTS 4 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Leny Nascimento da Motta Passos Phone/ Fax: (92) 3664-2616 / (92) 8802-6801 E-mail: cncdo.am@saude.gov.br Amazonas still has low rates of organ donation and kidney transplantation. ORGAN DONATION Effective donors: - pmp North Amazonas Number of effective donors 0 0 0 0 5 22 17 20 Number of effective donors (pmp) 0.0 0.0 0.0 0.0 1.4 6.3 4.9 5.7 Potential donors 0 0 0 0 21 92 129 126 Number of potential donors(pmp) 0.0 0.0 0.0 0.0 6.0 26.4 37.0 36.2 Non consenting families 0 0 0 0 9 30 41 42 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 57 65 66 Cardiopulmonary Arrest Unavailable 0 0 0 2 1 2 0 Medical Contraindications 0 0 0 0 2 18 28 12 Others 0 0 0 0 3 21 41 52 32

AMAZONAS Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp North Amazonas Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 1 1 1 1 1 1 1 1 LIVER 0 0 0 0 0 0 0 1 PANCREAS (not performed) HEART (not performed) Absolute number of transplants CORNEA 82 84 95 120 109 160 209 187 KIDNEY - total 22 21 25 24 32 70 41 22 living donor 22 21 25 24 22 27 17 10 deceased donor 0 0 0 0 10 43 24 12 LIVER 0 0 0 0 0 0 0 3 PANCREAS (not performed) HEART (not performed) Number of transplants pmp CORNEA 25.5 26.1 29.5 34.4 31.3 45.9 60.0 53.7 KIDNEY - total 6.8 6.5 7.8 6.9 9.2 20.1 11.8 6.3 living donor 6.8 6.5 7.8 6.9 6.3 7.7 4.9 2.9 deceased donor 0.0 0.0 0.0 0.0 2.9 12.3 6.9 3.4 LIVER 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 PANCREAS (not performed) HEART (not performed) 33

BAHIA Population 14,016,906 (7.3%) Capital City: Salvador 2,675,656 Area (Km²) 564,692.67 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 1,262 841 350 84 Performed transplants 332 82 53 0 Number of Mortality per year All Causes 67,588 71,013 73,492 76,337 78,046 80,311 Unavailable Unavailable External Causes 9,440 10,653 11,493 12,168 11,968 13,233 Unavailable Unavailable Neurological Causes 869 919 1,010 1,032 1,132 1,127 Unavailable Unavailable Population (census IBGE) 14,080,654 14,080,654 14,080,654 14,016,906 14,016,906 14,016,906 14,016,906 14,016,906 HOSPITALS % Nº Total 524 (8.6) State s capital 58 Country side 466 Nº of beds 29,531 (6.3) Nº of ICU beds 1650 (4.3) Hospitals over 80 beds 88 Teaching hospitals 6 Medical schools 14 (6.3) Neurosurgery services 24 (5.8) Number of CIHDOTTS 7 Number of OPOs 7 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Eraldo Salustiano de Moura Phone: (71) 3356-6776 E-mail: transplantes.ba@gmail.com Bahia has seven organ procurement organizations across the state and has been showing slowly increasing numbers of organ donation and transplantation, mainly corneal transplants, over the last years. Yet, notification rate are still low and family refusal rates remains higher than 60%. ORGAN DONATION Effective donors: - pmp Northeast Bahia Number of effective donors 46 47 53 57 69 77 97 109 Number of effective donors (pmp) 3.3 3.3 3.8 4.1 4.9 5.5 6.9 7.8 Potential donors 186 329 320 346 374 414 417 455 Number of potential donors(pmp) 13.2 23.4 22.7 24.7 26.7 29.5 29.7 32.5 Non consenting families 72 94 70 107 132 174 178 176 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 63 65 62 Cardiopulmonary Arrest Unavailable 19 18 12 8 23 9 27 Medical Contraindications 43 35 17 23 32 35 47 42 Others 25 134 162 147 133 105 86 101 34

BAHIA Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Northeast Bahia Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 4 4 4 4 4 4 4 5 LIVER 2 2 2 2 2 2 2 2 PANCREAS (not performed) HEART 0 1 1 0 0 0 0 0 Absolute number of transplants CORNEA 119 258 209 200 231 408 428 332 KIDNEY - total 70 68 96 78 73 105 114 82 living donor 24 30 40 29 29 18 28 19 deceased donor 46 38 56 49 44 87 86 63 LIVER 35 34 41 37 48 56 64 53 PANCREAS (not performed) HEART 0 2 3 0 0 0 0 0 Number of transplants pmp CORNEA 8.5 18.3 14.8 14.3 16.5 29.1 30.5 23.7 KIDNEY - total 5.0 4.8 6.8 5.6 5.2 7.5 8.4 5.9 living donor 1.7 2.1 2.8 2.1 2.1 1.3 2.0 1.4 deceased donor 3.3 2.7 4.0 3.5 3.1 6.2 6.1 4.5 LIVER 2.5 2.4 2.9 2.6 3.4 4.0 4.6 3.8 PANCREAS (not performed) HEART 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 35

CEARÁ Population 8,452,381 (4.4%) Capital City: Forteza 2,452,185 Area (Km²) 148,825.60 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 761 507 211 51 Performed transplants 786 283 195 21 Number of Mortality per year All Causes 40,426 43,100 44,194 43,847 47,886 48,712 Unavailable Unavailable External Causes 5,645 5,801 5,849 7,047 7,420 8,433 Unavailable Unavailable Neurological Causes 759 879 862 918 1,041 1,060 Unavailable Unavailable Population (census IBGE) 8,185,286 8,185,286 8,185,286 8,452,381 8,452,381 8,452,381 8,452,381 8,452,381 HOSPITALS % Nº Total 263 (4.3) State s capital 73 Country side 190 Nº of beds 17,293 (3.7) Nº of ICU beds 916 (2.4) Hospitals over 80 beds 60 Teaching hospitals 3 Medical schools 7 (3.2) Neurosurgery services 10 (2.4) Number of CIHDOTTS 15 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Eliana Régia Barbosa de Almeida Phone: (85) 3252-1886 / 3101-5238 E-mail: cncdo@saude.ce.gov.br Ceará has been showing continuous increase in organ donation and transplantation, leading to an effective donor rate well above the national average. These figures contributed to reduce inequalities in the Northeast region. ORGAN DONATION Effective donors: - pmp Northeast Ceará Number of effective donors 70 83 94 127 148 181 188 220 Number of effective donors (pmp) 8.6 10.1 11.5 15.0 17.5 21.4 22.2 26.0 Potential donors 233 237 260 325 373 435 527 624 Number of potential donors(pmp) 28.5 29.0 31.8 38.5 44.1 51.5 62.4 73.8 Non consenting families 65 55 51 80 102 110 157 187 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 37 44 45 Cardiopulmonary Arrest Unavailable 27 47 73 87 89 110 95 Medical Contraindications 72 56 55 36 31 52 64 108 Others 26 16 13 9 5 3 8 14 36

CEARÁ Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Northeast Ceará Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 3 4 4 4 3 3 3 5 LIVER 1 2 3 3 3 3 3 3 PANCREAS 0 0 1 1 2 2 2 1 HEART 1 1 1 1 1 1 1 1 LUNG 0 0 0 0 1 1 1 1 Absolute number of transplants CORNEA 376 473 420 436 786 718 764 786 KIDNEY - total 140 164 201 229 260 285 262 283 living donor 46 60 53 55 47 28 14 13 deceased donor 94 104 148 174 213 257 248 270 LIVER 64 73 84 114 158 160 194 195 PANCREAS 0 0 1 6 10 12 10 5 HEART 22 31 25 16 25 29 30 21 LUNG 0 0 0 0 4 4 8 11 Number of transplants pmp CORNEA 45.9 57.8 51.3 51.6 93.0 84.9 90.4 93.0 KIDNEY - total 17.1 20.0 24.6 27.1 30.8 33.7 31.0 33.5 living donor 5.6 7.3 6.5 6.5 5.6 3.3 1.7 1.5 deceased donor 11.5 12.7 18.1 20.6 25.2 30.4 29.3 31.9 LIVER 7.8 8.9 10.3 13.5 18.7 18.9 23.0 23.1 PANCREAS 0.0 0.0 0.1 0.7 1.2 1.4 1.2 0.6 HEART 2.7 3.8 3.1 1.9 3.0 3.4 3.5 2.5 LUNG 0.0 0.0 0.0 0.0 0.5 0.5 0.9 1.3 37

DISTRITO FEDERAL - Brasília Population 2,570,160 (1.3%) Capital City: Brasília 2,570,160 Area (Km²) 5,801.94 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 231 154 64 15 Performed transplants 351 100 54 25 Number of Mortality per year All Causes 9,866 10,284 10,459 10,851 11,253 11,308 Unavailable Unavailable External Causes 1,746 1,848 1,918 1,878 1,940 2,051 Unavailable Unavailable Neurological Causes 226 224 253 287 310 296 Unavailable Unavailable Population (census IBGE) 2,455,903 2,455,903 2,455,903 2,570,160 2,570,160 2,570,160 2,570,160 2,570,160 HOSPITALS % Nº Total 54 (0.9) State s capital 21 Country side 33 Nº of beds 7,811 (1.7) Nº of ICU beds 1065 (2.8) Hospitals over 80 beds 28 Teaching hospitals 3 Medical schools 5 (2.3) Neurosurgery services 5 (1.2) Number of CIHDOTTS 0 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Daniela Ferreira Salomão Phone:(61) 3315-1664 / (61) 3315-1755 E-mail: centraldetransplantedf@gmail.com Distrito Federal remains among the top regions in the number of effective donors in. ORGAN DONATION Effective donors: - pmp Midwest Distrito Federal Number of effective donors 19 20 29 42 29 56 85 75 Number of effective donors (pmp) 7.7 8.1 11.8 16.3 11.3 21.8 33.1 29.2 Potential donors 181 188 169 199 207 248 342 336 Number of potential donors(pmp) 73.7 76.6 68.8 77.4 80.5 96.5 133.1 130.7 Non consenting families 22 19 40 31 29 44 69 75 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 44 39 48 Cardiopulmonary Arrest Unavailable 9 9 6 9 10 19 1 Medical Contraindications 114 61 79 78 90 75 108 163 Others 26 79 12 42 50 63 61 22 38

DISTRITO FEDERAL - Brasília Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp DF Midwest Distrito Federal Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 3 3 4 3 2 3 4 4 LIVER 0 0 0 0 0 2 2 2 PANCREAS (not performed) HEART 1 1 1 1 1 1 1 1 LUNG 0 0 0 0 0 0 1 0 Absolute number of transplants CORNEA 197 342 390 360 319 432 306 351 KIDNEY - total 35 51 64 72 58 106 129 100 living donor 17 24 32 22 13 17 14 10 deceased donor 18 27 32 50 45 89 115 90 LIVER 0 0 0 0 0 39 53 54 PANCREAS (not performed) HEART 3 2 7 3 9 18 29 25 LUNG 0 0 0 0 0 0 2 0 Number of transplants pmp CORNEA 80.2 139.3 158.8 140.1 124.1 168.1 119.1 136.6 KIDNEY - total 14.3 20.8 26.1 28.0 22.6 41.2 50.2 38.9 living donor 6.9 9.8 13.0 8.6 5.1 6.6 5.4 3.9 deceased donor 7.3 11.0 13.0 19.5 17.5 34.6 44.7 35.0 LIVER 0.0 0.0 0.0 0.0 0.0 15.2 20.6 21.0 PANCREAS (not performed) HEART 1.2 0.8 2.9 1.2 3.5 7.0 11.3 9.7 LUNG 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 39

ESPÍRITO SANTO Population 3,514,952 (1.8%) Capital City: Vitória 327,801 Area (Km²) 46,077.52 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 316 211 88 21 Performed transplants 308 88 40 7 Number of Mortality per year All Causes 19,641 20,447 20,396 21,205 21,403 21,616 Unavailable Unavailable External Causes 3,881 3,984 3,930 3,944 3,804 3,995 Unavailable Unavailable Neurological Causes 402 503 526 546 647 713 Unavailable Unavailable Population (census IBGE) 3,351,669 3,351,669 3,351,669 3,514,952 3,514,952 3,514,952 3,514,952 3,514,952 HOSPITALS % Nº Total 114 (1.8) State s capital 21 Country side 93 Nº of beds 8,890 (1.9) Nº of ICU beds 813 (2.1) Hospitals over 80 beds 37 Teaching hospitals 0 Medical schools 5 (2.3) Neurosurgery services 10 (2.4) Number of CIHDOTTS 40 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Rosemery Gueis Nunes Erlacher Phone: (27) 3235-1028 E-mail: cncdo@saude.es.gov.br Espirito Santo also established program for organ donation and transplantation. ORGAN DONATION Effective donors: - pmp Southeast Espírito Santo Number of effective donors 17 28 38 46 36 51 43 46 Number of effective donors (pmp) 5.1 8.4 11.3 13.1 10.2 14.5 12.2 13.1 Potential donors 132 137 149 169 153 196 174 195 Number of potential donors(pmp) 39.4 40.9 44.5 48.1 43.5 55.8 49.5 55.5 Non consenting families 61 41 44 41 47 41 49 48 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 40 59 50 Cardiopulmonary Arrest Unavailable 1 3 23 14 3 0 2 Medical Contraindications 46 63 59 41 20 16 23 32 Others 8 4 5 18 36 85 59 67 40

ESPÍRITO SANTO Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Southeast Espírito Santo Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 4 4 5 5 4 3 3 2 LIVER 1 1 2 2 2 1 1 1 PANCREAS 0 0 0 0 0 0 0 0 HEART 0 1 1 1 1 1 1 1 Absolute number of transplants CORNEA 67 122 131 159 326 304 213 308 KIDNEY - total 53 88 96 98 84 99 100 88 living donor 23 37 38 27 31 26 27 29 deceased donor 30 51 58 71 53 73 73 59 LIVER 9 20 29 32 24 32 24 40 PANCREAS 0 0 0 0 0 0 0 0 HEART 0 4 1 8 3 7 3 7 Number of transplants pmp CORNEA 20.0 36.4 39.1 45.2 92.7 86.5 60.6 87.6 KIDNEY - total 15.8 26.3 28.6 27.9 23.9 28.2 28.4 25.0 living donor 6.9 11.0 11.3 7.7 8.8 7.4 7.7 8.3 deceased donor 9.0 15.2 17.3 20.2 15.1 20.8 20.8 16.8 LIVER 2.7 6.0 8.7 9.1 6.8 9.1 6.8 11.4 PANCREAS 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 HEART 0.0 1.2 0.3 2.3 0.9 2.0 0.9 2.0 41

GOIÁS Population 6,003,788 (3.1%) Capital City: Goiânia 1,302,001 Area (Km²) 340,086.70 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 540 360 150 36 Performed transplants 735 65 0 0 Number of Mortality per year All Causes 28,153 30,146 30,496 32,656 34,154 36,000 Unavailable Unavailable External Causes 4,294 4,865 4,921 5,279 5,542 6,371 Unavailable Unavailable Neurological Causes 498 532 566 667 719 802 Unavailable Unavailable Population (census IBGE) 5,647,035 5,647,035 5,647,035 6,003,788 6,003,788 6,003,788 6,003,788 6,003,788 HOSPITALS % Nº Total 420 (6.9) State s capital 115 Country side 305 Nº of beds 17,991 (3.8) Nº of ICU beds 1153 (3.0) Hospitals over 80 beds 50 Teaching hospitals 2 Medical schools 4 (1.8) Neurosurgery services 12 (2.9) Number of CIHDOTTS 1 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Luciano Leão Bernardino da Costa Phone/Fax: (62) 3201-6270 / 3201-6721 E-mail: centraltransplantes.go@saude.gov.br Goiás has registered an increase in the number of potential and effective deceased donors but conversion rate into effective donors remains very low (10%). While the number of kidney transplants has been stable, the number of corneal transplants recovered partially in 2014. ORGAN DONATION Effective donors: - pmp Midwest Goiás Number of effective donors 11 14 29 18 26 24 21 26 Number of effective donors (pmp) 1.9 2.5 5.1 3.0 4.3 4.0 3.5 4.3 Potential donors 182 189 219 204 201 181 232 260 Number of potential donors(pmp) 32.2 33.5 38.8 34.0 33.5 30.1 38.6 43.3 Non consenting families 42 44 37 66 41 28 67 104 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 51 63 82 Cardiopulmonary Arrest Unavailable 41 44 74 97 83 87 10 Medical Contraindications 37 84 107 40 30 20 27 26 Others 92 6 2 6 7 26 30 94 42

GOIÁS Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Midwest Goiás Liver - pmp (not performed) CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 3 3 2 2 3 2 4 4 LIVER (not performed) PANCREAS 0 1 0 0 0 1 1 1 HEART 0 0 1 1 0 0 0 0 Absolute number of transplants CORNEA 418 426 404 428 836 982 698 735 KIDNEY - total 15 42 74 73 99 69 71 65 living donor 8 19 29 44 47 37 34 22 deceased donor 7 23 45 29 52 32 37 43 LIVER (not performed) PANCREAS 0 1 0 0 0 6 2 3 HEART 0 0 2 1 0 0 0 0 Number of transplants pmp CORNEA 74.0 75.4 71.5 71.3 139.2 163.6 116.3 122.4 KIDNEY - total 2.7 7.4 13.1 12.2 16.5 11.5 11.8 10.8 living donor 1.4 3.4 5.1 7.3 7.8 6.2 5.7 3.7 deceased donor 1.2 4.1 8.0 4.8 8.7 5.3 6.2 7.2 LIVER (not performed) PANCREAS 0.0 0.2 0.0 0.0 0.0 1.0 0.3 0.5 HEART 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.0 43

MARANHÃO Population 6,574,789 (3.4%) Capital City: São Luís 1,014,837 Area (Km²) 331,983.29 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 592 394 164 39 Performed transplants 107 34 0 0 Number of Mortality per year All Causes 23,821 25,407 25,734 26,091 28,970 28,838 Unavailable Unavailable External Causes 3,143 3,502 3,585 3,887 4,135 4,663 Unavailable Unavailable Neurological Causes 282 378 342 391 401 402 Unavailable Unavailable Population (census IBGE) 6,118,995 6,118,995 6,118,995 6,574,789 6,574,789 6,574,789 6,574,789 6,574,789 HOSPITALS % Nº Total 232 (3.8) State s capital 39 Country side 193 Nº of beds 12,965 (2.8) Nº of ICU beds 595 (1.5) Hospitals over 80 beds 38 Teaching hospitals 0 Medical schools 3 (1.4) Neurosurgery services 3 (0.7) Number of CIHDOTTS 8 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Silvana S Santos Oliveira Phone: (98) 2109-1276 / 2109-1212 E-mail: ctx@huufma.br Maranhão has very low numbers of potential and effective donors and consequently low transplant numbers. Actions to increase the number of well-trained professionals involved in organ donation are needed to reduce the rates found in this state. ORGAN DONATION Effective donors: - pmp Northeast Maranhão Number of effective donors 11 10 14 11 4 6 2 7 Number of effective donors (pmp) 1.8 1.6 2.3 1.7 0.6 0.9 0.3 1.1 Potential donors 26 62 102 111 92 72 85 90 Number of potential donors(pmp) 4.2 10.1 16.7 16.9 14.0 11.0 12.9 13.7 Non consenting families 5 34 33 37 33 25 15 13 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 81 88 57 Cardiopulmonary Arrest Unavailable 9 15 23 2 11 0 1 Medical Contraindications 5 0 17 9 13 11 25 25 Others 5 9 23 31 40 19 43 44 44

MARANHÃO Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Northeast Maranhão Liver - pmp (not performed) CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 1 1 1 1 1 1 1 2 LIVER (not performed) PANCREAS (not performed) HEART (not performed) Absolute number of transplants CORNEA 61 79 129 128 119 208 119 107 KIDNEY - total 34 43 38 45 44 28 30 34 living donor 26 20 16 25 18 13 12 16 deceased donor 8 23 22 20 26 15 18 18 LIVER (not performed) PANCREAS (not performed) HEART (not performed) Number of transplants pmp CORNEA 10.0 12.9 21.1 19.5 18.1 31.6 18.1 16.3 KIDNEY - total 5.6 7.0 6.2 6.8 6.7 4.3 4.6 5.2 living donor 4.2 3.3 2.6 3.8 2.7 2.0 1.8 2.4 deceased donor 1.3 3.8 3.6 3.0 4.0 2.3 2.7 2.7 LIVER (not performed) PANCREAS (not performed) HEART (not performed) 45

MATO GROSSO Population 3,035,122 (1.6%) Capital City: Cuiabá 551,098 Area (Km²) 903,357.91 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 273 182 76 18 Performed transplants 116 0 0 0 Number of Mortality per year All Causes 12,792 13,872 14,267 14,986 15,239 15,901 Unavailable Unavailable External Causes 2,495 2,734 2,912 2,861 2,815 3,027 Unavailable Unavailable Neurological Causes 187 208 220 266 281 351 Unavailable Unavailable Population (census IBGE) 2,854,642 2,854,642 2,854,642 3,035,122 3,035,122 3,035,122 3,035,122 3,035,122 HOSPITALS % Nº Total 158 (2.6) State s capital 23 Country side 135 Nº of beds 7,404 (1.6) Nº of ICU beds 596 (1.5) Hospitals over 80 beds 23 Teaching hospitals 2 Medical schools 4 (1.8) Neurosurgery services 4 (1.0) Number of CIHDOTTS 2 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Fabiana Regina de Souza Molina Phone: (65) 3324-0747 / 3623-9004 E-mail: contran@ses.mt.gov.br Mato Grosso has an effective program of corneal transplantation, but still no certified centers to performed solid organ transplants. ORGAN DONATION Effective donors: - pmp Midwest Mato Grosso Number of effective donors 6 4 7 3 6 1 0 0 Number of effective donors (pmp) 2.1 1.4 2.5 1.0 2.0 0.3 0.0 0.0 Potential donors 57 57 61 61 66 75 64 45 Number of potential donors(pmp) 20.0 20.0 21.4 20.1 21.7 24.7 21.1 14.8 Non consenting families 25 15 11 12 11 11 10 0 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 50 77 0 Cardiopulmonary Arrest Unavailable 3 12 23 37 39 13 0 Medical Contraindications 19 24 21 12 6 12 2 0 Others 7 11 10 11 6 12 39 45 46

MATO GROSSO Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Midwest Mato Grosso Liver - pmp (not performed) CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 1 1 1 0 0 0 0 0 LIVER (not performed) PANCREAS (not performed) HEART (not performed) Absolute number of transplants CORNEA 156 162 117 53 285 200 186 116 KIDNEY - total 9 6 4 0 0 0 0 0 living donor 9 2 2 0 0 0 0 0 deceased donor 0 4 2 0 0 0 0 0 LIVER (not performed) PANCREAS (not performed) HEART (not performed) Number of transplants pmp CORNEA 54.6 56.7 41.0 17.5 93.9 65.9 61.3 38.2 KIDNEY - total 3.2 2.1 1.4 0.0 0.0 0.0 0.0 0.0 living donor 3.2 0.7 0.7 0.0 0.0 0.0 0.0 0.0 deceased donor 0.0 1.4 0.7 0.0 0.0 0.0 0.0 0.0 LIVER (not performed) PANCREAS (not performed) HEART (not performed) 47

MATO GROSSO DO SUL Population 2,449,024 (1.3%) Capital City: Campo Grande 786,797 Area (Km²) 357,124.96 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 220 147 61 15 Performed transplants 139 0 0 0 Number of Mortality per year 2007 2008 2009 2010 2011 2012 2013 2013 All Causes 13,208 13,235 13,610 14,471 14,291 14,634 Unavailable Unavailable External Causes 2,006 2,004 2,110 2,120 2,224 2,187 Unavailable Unavailable Neurological Causes 303 307 281 348 359 406 Unavailable Unavailable Population (census IBGE) 2,265,274 2,265,274 2,265,274 2,449,024 2,449,024 2,449,024 2,449,024 2,449,024 HOSPITALS % Nº Total 113 (1.9) State s capital 23 Country side 90 Nº of beds 6,113 (1.3) Nº of ICU beds 356 (0.9) Hospitals over 80 beds 18 Teaching hospitals 2 Medical schools 4 (1.8) Neurosurgery services 3 (0.7) Number of CIHDOTTS 5 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Claire Carmem Miozzo Phone: (67) 3312-1456 E-mail: cet@saude.ms.gov.br Mato Grosso do Sul has a high rate of notification of potential Donors that has not translated into effective donations due to the very high rate of family refusal. ORGAN DONATION Effective donors: - pmp Midwest Mato Grosso do Sul Number of effective donors 10 9 10 9 11 17 18 14 Number of effective donors (pmp) 4.4 4.0 4.4 3.7 4.5 6.9 7.3 5.7 Potential donors 46 50 59 80 115 167 151 166 Number of potential donors(pmp) 20.3 22.1 26.0 32.7 47.0 68.2 61.7 67.8 Non consenting families 19 13 6 20 19 36 46 42 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 63 65 72 Cardiopulmonary Arrest Unavailable 7 11 8 14 16 24 20 Medical Contraindications 13 18 30 41 66 79 54 79 Others 4 3 2 2 5 19 9 11 48

MATO GROSSO DO SUL Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Midwest Mato Grosso do Sul Liver - pmp (not performed) CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 2 2 2 2 2 2 2 0 LIVER (not performed) PANCREAS (not performed) HEART 0 0 0 0 0 0 1 0 Absolute number of transplants CORNEA 180 173 180 177 180 197 187 139 KIDNEY - total 49 49 14 24 21 44 45 0 living donor 28 30 4 15 21 22 20 0 deceased donor 21 19 10 9 0 22 25 0 LIVER (not performed) PANCREAS (not performed) HEART 0 0 0 0 0 0 3 0 Number of transplants pmp CORNEA 79.5 76.4 79.5 72.3 73.5 80.4 76.4 56.8 KIDNEY - total 21.6 21.6 6.2 9.8 8.6 18.0 18.4 0.0 living donor 12.4 13.2 1.8 6.1 8.6 9.0 8.2 0.0 deceased donor 9.3 8.4 4.4 3.7 0.0 9.0 10.2 0.0 LIVER (not performed) PANCREAS (not performed) HEART 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 49

MINAS GERAIS Population 19,597,330 (10.3%) Capital City: Belo Horizonte 2,375,151 Area (Km²) 586,528.29 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 1,764 1,176 490 118 Performed transplants 1,419 588 91 39 Number of Mortality per year All Causes 111,366 112,756 114,301 120,803 122,653 125,074 Unavailable Unavailable External Causes 12,415 12,187 12,681 12,931 14,263 14,237 Unavailable Unavailable Neurological Causes 2,424 2,529 2,701 3,057 3,231 3,431 Unavailable Unavailable Population (census IBGE) 19,273,506 19,273,506 19,273,506 19,597,330 19,597,330 19,597,330 19,597,330 19,597,330 HOSPITALS % Nº Total 615 (10.1) State s capital 66 Country side 549 Nº of beds 45,517 (9.7) Nº of ICU beds 3827 (9.9) Hospitals over 80 beds 167 Teaching hospitals 19 Medical schools 35 (15.8) Neurosurgery services 43 (10.4) Number of CIHDOTTS 60 Number of OPOs 10 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Charles Simão Filho Phone: (31) 3219-9200 E-mail: mgtransplantes@saude.mg.gov.br Minas Gerais has well consolidated transplant programs and organ organ procurement organizations. Its donation rate increased in the last year but remains below the national average. ORGAN DONATION Effective donors: - pmp Southeast Minas Gerais Number of effective donors 110 153 149 161 193 245 228 245 Number of effective donors (pmp) 5.7 7.9 7.7 8.2 9.8 12.5 11.6 12.5 Potential donors 370 478 462 493 469 608 601 617 Number of potential donors(pmp) 19.2 24.8 24.0 25.2 23.9 31.0 30.7 31.5 Non consenting families 86 90 74 87 89 128 143 152 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 31 43 44 Cardiopulmonary Arrest Unavailable 114 105 133 73 42 87 79 Medical Contraindications 158 93 112 89 75 40 54 41 Others 16 28 22 23 39 153 89 100 50

MINAS GERAIS Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp DF Brasília Southeast Minas Gerais Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 18 20 18 17 16 16 16 17 LIVER 2 3 2 1 3 5 4 3 PANCREAS 3 2 2 2 2 2 3 3 HEART 3 2 2 1 2 2 2 2 LUNG 1 1 1 1 1 1 1 1 Absolute number of transplants CORNEA 138 1,973 1,446 1,334 1,414 1,391 1,441 1,419 KIDNEY - total 379 435 452 461 506 562 536 588 living donor 194 175 200 195 191 179 187 186 deceased donor 185 260 252 266 315 383 349 402 LIVER 64 84 58 78 81 110 75 91 PANCREAS 14 6 17 13 16 30 18 19 HEART 18 26 19 24 12 30 27 39 LUNG 2 2 2 3 1 1 2 1 Number of transplants pmp CORNEA 7.2 102.4 75.0 68.1 72.2 71.0 73.5 72.4 KIDNEY - total 19.7 22.6 23.5 23.5 25.8 28.7 27.4 30.0 living donor 10.1 9.1 10.4 10.0 9.7 9.1 9.5 9.5 deceased donor 9.6 13.5 13.1 13.6 16.1 19.5 17.8 20.5 LIVER 3.3 4.4 3.0 4.0 4.1 5.6 3.8 4.6 PANCREAS 0.7 0.3 0.9 0.7 0.8 1.5 0.9 1.0 HEART 0.9 1.3 1.0 1.2 0.6 1.5 1.4 2.0 LUNG 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 51

PARÁ Population 7,581,051 (4.0%) Capital City: Belém 1,393,399 Area (Km²) 1,247,689.52 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 682 455 190 45 Performed transplants 212 50 0 0 Number of Mortality per year All Causes 27,626 29,633 30,512 31,600 32,638 33,898 Unavailable Unavailable External Causes 4,385 5,232 5,200 6,125 5,744 6,197 Unavailable Unavailable Neurological Causes 342 353 374 363 390 461 Unavailable Unavailable Population (census IBGE) 7,065,573 7,065,573 7,065,573 7,581,051 7,581,051 7,581,051 7,581,051 7,581,051 HOSPITALS % Nº Total 230 (3.8) State s capital 44 Country side 186 Nº of beds 15,768 (3.4) Nº of ICU beds 893 (2.3) Hospitals over 80 beds 53 Teaching hospitals 3 Medical schools 4 (1.8) Neurosurgery services 8 (1.9) Number of CIHDOTTS 9 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Ana Cristina Simões Beltrão Phone/Fax: (91) 4006-4284 E-mail: cncdo.transplantes@gmail.com Pará currently has very low rates of notifications and effective deceased donors. rates are still low. Only corneal and kidney transplants were performed in 2014 in this state. ORGAN DONATION Effective donors: - pmp North Pará Number of effective donors 8 9 12 9 26 22 19 18 Number of effective donors (pmp) 1.1 1.3 1.7 1.2 3.4 2.9 2.5 2.4 Potential donors 115 102 124 97 117 133 133 129 Number of potential donors(pmp) 16.3 14.4 17.5 12.8 15.4 17.5 17.5 17.0 Non consenting families 41 38 26 43 51 47 36 40 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 35 31 55 Cardiopulmonary Arrest Unavailable 23 17 20 15 30 25 22 Medical Contraindications 39 25 49 16 20 27 41 23 Others 27 7 20 9 5 7 12 26 52

PARÁ Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp North Pará Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 1 1 1 1 1 2 3 3 LIVER 1 0 PANCREAS (not performed) HEART 1 0 0 0 0 0 0 0 Absolute number of transplants CORNEA 96 110 135 140 160 284 211 212 KIDNEY - total 20 19 22 35 55 49 53 50 living donor 8 4 4 13 5 7 12 13 deceased donor 12 15 18 22 50 42 41 37 LIVER 0 0 0 0 0 0 1 0 PANCREAS (not performed) HEART 1 0 0 0 0 0 0 0 Number of transplants pmp CORNEA 13.6 15.6 19.1 18.5 21.1 37.5 27.8 28.0 KIDNEY - total 2.8 2.7 3.1 4.6 7.3 6.5 7.0 6.6 living donor 1.1 0.6 0.6 1.7 0.7 0.9 1.6 1.7 deceased donor 1.7 2.1 2.5 2.9 6.6 5.5 5.4 4.9 LIVER 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 PANCREAS (not performed) HEART 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 53

PARAÍBA Population 3,766,528 (2.0%) Capital City: João Pessoa 723,515 Area (Km²) 56,439.84 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 339 226 94 23 Performed transplants 140 39 1 0 Number of Mortality per year All Causes 21,275 22,522 22,797 23,407 24,579 25,168 Unavailable Unavailable External Causes 2,144 2,494 2,731 2,907 3,093 3,191 Unavailable Unavailable Neurological Causes 328 412 411 428 443 517 Unavailable Unavailable Population (census IBGE) 3,641,395 3,641,395 3,641,395 3,766,528 3,766,528 3,766,528 3,766,528 3,766,528 HOSPITALS % Nº Total 144 (2.4) State s capital 39 Country side 105 Nº of beds 8,835 (1.9) Nº of ICU beds 496 (1.3) Hospitals over 80 beds 36 Teaching hospitals 1 Medical schools 8 (3.6) Neurosurgery services 6 (1.4) Number of CIHDOTTS 7 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Gyanna Lys de Melo Moreira Montenegro Phone/Fax: (83) 3244-6192 / 3225-6409 E-mail: transplante@gmail.com Paraiba still has low numbers of effective donors and transplants. One center performed all kidney transplants in this state a liver transplant program has being started in 2014. ORGAN DONATION Effective donors: - pmp Northeast Paraíba Number of effective donors 6 7 11 25 9 18 17 10 Number of effective donors (pmp) 1.6 1.9 3.0 6.6 2.4 4.8 4.5 2.7 Potential donors 114 88 112 183 119 169 139 161 Number of potential donors(pmp) 31.3 24.2 30.8 48.6 31.6 44.9 36.9 42.7 Non consenting families 23 25 26 52 25 44 31 28 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 64 58 64 Cardiopulmonary Arrest Unavailable 32 40 32 16 4 4 3 Medical Contraindications 79 14 25 40 31 32 13 20 Others 6 10 10 34 38 71 74 100 54

PARAÍBA Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Northeast Paraíba Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 2 2 3 3 1 1 1 1 LIVER 1 1 1 1 1 1 0 1 PANCREAS (not performed) HEART 0 0 1 0 0 0 0 0 Absolute number of transplants CORNEA 185 135 202 178 155 99 165 140 KIDNEY - total 8 10 13 32 29 50 53 39 living donor 0 6 9 11 14 21 25 22 deceased donor 8 4 4 21 15 29 28 17 LIVER 4 5 5 11 3 1 0 1 PANCREAS (not performed) HEART 0 0 1 0 0 0 0 0 Number of transplants pmp CORNEA 50.8 37.1 55.5 47.3 41.2 26.3 43.8 37.2 KIDNEY - total 2.2 2.7 3.6 8.5 7.7 13.3 14.1 10.4 living donor 0.0 1.6 2.5 2.9 3.7 5.6 6.6 5.8 deceased donor 2.2 1.1 1.1 5.6 4.0 7.7 7.4 4.5 LIVER 1.1 1.4 1.4 2.9 0.8 0.3 0.0 0.3 PANCREAS (not performed) HEART 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 55

PARANÁ Population 10,444,526 (5.5%) Capital City: Curitiba 1,751,907 Area (Km²) 199,314.85 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 940 627 261 63 Performed transplants 811 432 99 32 Number of Mortality per year All Causes 61,597 63,781 64,960 66,969 68,598 68,637 Unavailable Unavailable External Causes 8,832 9,074 9,286 9,535 9,376 9,832 Unavailable Unavailable Neurological Causes 1,265 1,356 1,464 1,641 1,766 1,992 Unavailable Unavailable Population (census IBGE) 10,284,503 10,284,503 10,284,503 10,444,526 10,444,526 10,444,526 10,444,526 10,444,526 HOSPITALS % Nº Total 470 (7.7) State s capital 64 Country side 406 Nº of beds 29,944 (6.4) Nº of ICU beds 2531 (6.5) Hospitals over 80 beds 107 Teaching hospitals 13 Medical schools 13 (5.9) Neurosurgery services 40 (9.6) Number of CIHDOTTS 60 Number of OPOs 3 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Arlene Terezinha Cagol Garcia Badoch Phone/Fax: (41) 3304-1900/ 1909 E-mail: sesatran@sesa.pr.gov.br Paraná has had a well-established transplantation program for many decades. The growing number of effective donors and transplants in the last years decreased slightly in 2014. ORGAN DONATION Effective donors: - pmp South Paraná Number of effective donors 78 66 91 93 112 151 191 173 Number of effective donors (pmp) 7.6 6.4 8.8 8.9 10.7 14.5 18.3 16.6 Potential donors 307 326 372 370 401 488 597 570 Number of potential donors(pmp) 29.9 31.7 36.2 35.4 38.4 46.7 57.2 54.6 Non consenting families 81 105 103 90 122 159 156 153 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 48 42 45 Cardiopulmonary Arrest Unavailable 8 11 50 59 66 93 93 Medical Contraindications 135 93 167 137 52 51 157 151 Others 13 54 0 56 61 0 0 56

PARANÁ Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp DF South Paraná Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 19 16 16 13 15 14 14 14 LIVER 3 3 5 5 6 6 5 5 PANCREAS 4 3 2 2 3 2 1 1 HEART 6 6 5 4 5 4 5 5 Absolute number of transplants CORNEA 472 1,000 947 832 1,178 1,007 744 811 KIDNEY - total 273 298 322 299 382 435 450 432 living donor 189 191 198 192 214 174 173 178 deceased donor 84 107 124 107 168 261 277 254 LIVER 52 62 62 51 76 106 118 99 PANCREAS 17 20 3 5 25 18 23 21 HEART 43 34 23 15 18 26 23 32 Number of transplants pmp CORNEA 45.9 97.2 92.1 79.7 112.8 96.4 71.2 77.6 KIDNEY - total 26.5 29.0 31.3 28.6 36.6 41.6 43.1 41.4 living donor 18.4 18.6 19.3 18.4 20.5 16.7 16.6 17.0 deceased donor 8.2 10.4 12.1 10.2 16.1 25.0 26.5 24.3 LIVER 5.1 6.0 6.0 4.9 7.3 10.1 11.3 9.5 PANCREAS 1.7 1.9 0.3 0.5 2.4 1.7 2.2 2.0 HEART 4.2 3.3 2.2 1.4 1.7 2.5 2.2 3.1 57

PERNAMBUCO Population 8,796,448 (4.6%) Capital City: Recife 1,537,704 Area (Km²) 98,311.62 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 792 528 220 53 Performed transplants 759 279 115 25 Number of Mortality per year All Causes 53,338 54,124 54,678 54,570 57,219 57,132 Unavailable Unavailable External Causes 8,148 8,157 7,968 7,646 7,771 7,483 Unavailable Unavailable Neurological Causes 618 726 705 811 904 992 Unavailable Unavailable Population (census IBGE) 8,485,386 8,485,386 8,485,386 8,796,448 8,796,448 8,796,448 8,796,448 8,796,448 HOSPITALS % Nº Total 227 (3.7) State s capital 51 Country side 176 Nº of beds 20,660 (4.4) Nº of ICU beds 1572 (4.1) Hospitals over 80 beds 77 Teaching hospitals 6 Medical schools 6 (2.7) Neurosurgery services 16 (3.9) Number of CIHDOTTS 20 Number of OPOs 4 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Noemy Gomes Phone: (81) ) 3181-6207/ 6206/ 6209 E-mail: transplantespe@saude.gov.br Pernambuco has a well-structured transplantation program. Despite the growing number of potential and effective donors as well as transplants, family refusal rate remains elevated. ORGAN DONATION Effective donors: - pmp Northeast Pernambuco Number of effective donors 41 59 70 57 70 116 117 145 Number of effective donors (pmp) 4.8 7.0 8.2 6.5 8.0 13.2 13.3 16.5 Potential donors 258 274 251 302 359 512 546 564 Number of potential donors(pmp) 30.4 32.3 29.6 34.3 40.8 58.2 62.1 64.1 Non consenting families 60 59 59 69 86 141 175 189 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 53 54 55 Cardiopulmonary Arrest Unavailable 17 19 30 29 16 22 14 Medical Contraindications 67 52 39 63 61 120 119 145 Others 90 87 64 83 113 119 113 71 58

PERNAMBUCO Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Northeast Pernambuco Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 8 9 6 6 6 4 4 5 LIVER 3 3 3 4 3 3 3 3 PANCREAS 0 0 0 0 0 1 1 1 HEART 1 1 1 1 1 2 2 2 Absolute number of transplants CORNEA 614 633 671 506 661 1,084 865 759 KIDNEY - total 116 164 182 180 200 278 281 279 living donor 43 45 41 42 32 33 16 26 deceased donor 73 119 141 138 168 245 265 253 LIVER 51 84 78 82 105 134 127 115 PANCREAS 0 0 0 0 0 3 3 5 HEART 7 6 8 7 8 18 27 25 Number of transplants pmp CORNEA 72.4 74.6 79.1 57.5 75.1 123.2 98.3 86.3 KIDNEY - total 13.7 19.3 21.4 20.5 22.7 31.6 31.9 31.7 living donor 5.1 5.3 4.8 4.8 3.6 3.8 1.8 3.0 deceased donor 8.6 14.0 16.6 15.7 19.1 27.9 30.1 28.8 LIVER 6.0 9.9 9.2 9.3 11.9 15.2 14.4 13.1 PANCREAS 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.6 HEART 0.8 0.7 0.9 0.8 0.9 2.0 3.1 2.8 59

PIAUÍ Population 3,118,360 (1.6%) Capital City: Teresina 814,230 Area (Km²) 251,529.19 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 281 187 78 19 Performed transplants 195 35 0 0 Number of Mortality per year All Causes 14,884 15,489 15,573 15,614 17,052 17,449 Unavailable Unavailable External Causes 1,654 1,789 1,860 1,975 2,083 2,314 Unavailable Unavailable Neurological Causes 240 296 267 258 274 297 Unavailable Unavailable Population (census IBGE) 3,032,421 3,032,421 3,032,421 3,118,360 3,118,360 3,118,360 3,118,360 3,118,360 HOSPITALS % Nº Total 124 (2.0) State s capital 36 Country side 88 Nº of beds 6,407 (1.4) Nº of ICU beds 309 (0.8) Hospitals over 80 beds 23 Teaching hospitals 1 Medical schools 4 (1.8) Neurosurgery services 3 (0.7) Number of CIHDOTTS 1 Number of OPOs 1 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Maria de Lourdes de Freitas Veras Phone/Fax: (86) 3221-7553 /3216-3553 E-mail: cncdopi@saude.pi.gov.br Piauí decreased slightly its rate of effective donors in 2014 and still faces a high family refusal rate. Only corneal and kidney transplants are performed. ORGAN DONATION Effective donors: - pmp Northeast Piauí Number of effective donors 4 1 7 8 7 10 18 17 Number of effective donors (pmp) 1.3 0.3 2.3 2.6 2.2 3.2 5.8 5.5 Potential donors 29 15 48 91 73 96 84 79 Number of potential donors(pmp) 9.6 4.9 15.8 29.2 23.4 30.8 26.9 25.3 Non consenting families 18 8 15 41 13 20 37 30 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 57 62 64 Cardiopulmonary Arrest Unavailable 0 4 11 17 37 3 7 Medical Contraindications 7 6 4 26 25 8 9 18 Others 0 0 18 5 11 21 17 7 60

PIAUÍ Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Northeast Piauí Liver - pmp (not performed) CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 2 2 2 3 3 3 3 2 LIVER (not performed) PANCREAS (not performed) HEART 1 0 0 0 0 0 0 0 Absolute number of transplants CORNEA 47 49 126 157 170 167 199 195 KIDNEY - total 36 28 31 43 42 39 41 35 living donor 12 24 15 19 25 23 11 13 deceased donor 24 4 16 24 17 16 30 22 LIVER (not performed) PANCREAS (not performed) HEART 1 0 0 0 0 0 0 0 Number of transplants pmp CORNEA 15.5 16.2 41.6 50.3 54.5 53.6 63.8 62.5 KIDNEY - total 11.9 9.2 10.2 13.8 13.5 12.5 13.1 11.2 living donor 4.0 7.9 4.9 6.1 8.0 7.4 3.5 4.2 deceased donor 7.9 1.3 5.3 7.7 5.5 5.1 9.6 7.1 LIVER (not performed) PANCREAS (not performed) HEART 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 61

RIO DE JANEIRO Population 15,989,929 (8.4%) Capital City: Rio de Janeiro 6,320,446 Area (Km²) 43,696.05 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 1,439 959 400 96 Performed transplants 301 468 188 12 Number of Mortality per year All Causes 120,217 122,534 123,890 127,536 127,095 126,261 Unavailable Unavailable External Causes 15,189 14,420 14,184 13,794 13,765 13,066 Unavailable Unavailable Neurological Causes 2,160 2,438 2,564 2,865 2,855 2,894 Unavailable Unavailable Population (census IBGE) 15,420,375 15,420,375 15,420,375 15,989,929 15,989,929 15,989,929 15,989,929 15,989,929 HOSPITALS % Nº Total 469 (7.7) State s capital 188 Country side 281 Nº of beds 46,272 (9.9) Nº of ICU beds 5360 (13.9) Hospitals over 80 beds 207 Teaching hospitals 10 Medical schools 15 (6.8) Neurosurgery services 38 (9.2) Number of CIHDOTTS 41 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Rodrigo Alves Sarlo Phone: (21) 2333-7535 / 7543 E-mail: transplantes@saude.rj.gov.br Rio de Janeiro has continuously increased its numbers of potential and effective donors as well as transplants. ORGAN DONATION Effective donors: - pmp Southeast Rio de Janeiro Number of effective donors 82 71 69 80 121 221 225 272 Number of effective donors (pmp) 5.3 4.6 4.5 5.0 7.6 13.8 14.1 17.0 Potential donors 488 421 526 498 556 688 869 973 Number of potential donors(pmp) 31.6 27.3 34.1 31.1 34.8 43.0 54.3 60.9 Non consenting families 148 114 131 126 153 179 229 216 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 45 50 44 Cardiopulmonary Arrest Unavailable 94 133 140 174 185 227 200 Medical Contraindications 187 105 149 112 72 59 135 189 Others 71 37 44 40 36 44 53 96 62

RIO DE JANEIRO Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp DF Southeast Rio de Janeiro Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 9 10 10 12 11 10 12 11 LIVER 4 4 4 7 7 6 7 6 PANCREAS 1 0 0 0 0 0 0 0 HEART 2 2 1 1 1 2 2 2 LUNG 1 0 0 0 0 0 0 0 Absolute number of transplants CORNEA 66 78 88 138 294 269 310 301 KIDNEY - total 211 211 205 186 251 367 416 468 living donor 86 110 106 85 94 115 132 94 deceased donor 125 101 99 101 157 252 284 374 LIVER 92 83 84 68 82 153 162 188 PANCREAS 1 0 0 0 0 0 0 0 HEART 4 5 8 6 5 11 10 12 LUNG 2 0 0 0 0 0 0 0 Number of transplants pmp CORNEA 4.3 5.1 5.7 8.6 18.4 16.8 19.4 18.8 KIDNEY - total 13.7 13.7 13.3 11.6 15.7 23.0 26.0 29.3 living donor 5.6 7.1 6.9 5.3 5.9 7.2 8.3 5.9 deceased donor 8.1 6.5 6.4 6.3 9.8 15.8 17.8 23.4 LIVER 6.0 5.4 5.4 4.3 5.1 9.6 10.1 11.8 PANCREAS 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 HEART 0.3 0.3 0.5 0.4 0.3 0.7 0.6 0.8 LUNG 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 63

RIO GRANDE DO NORTE Population 3,168,027 (1.7%) Capital City: Natal 803,739 Area (Km²) 52,796.79 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 285 190 79 19 Performed transplants 159 69 2 0 Number of Mortality per year All Causes 14,541 15,576 16,215 16,090 17,802 17,923 Unavailable Unavailable External Causes 1,934 2,084 2,286 2,162 2,414 2,544 Unavailable Unavailable Neurological Causes 276 319 315 345 389 424 Unavailable Unavailable Population (census IBGE) 3,013,740 3,013,740 3,013,740 3,168,027 3,168,027 3,168,027 3,168,027 3,168,027 HOSPITALS % Nº Total 86 (1.4) State s capital 28 Country side 58 Nº of beds 5,768 (1.2) Nº of ICU beds 495 (1.3) Hospitals over 80 beds 26 Teaching hospitals 2 Medical schools 3 (1.4) Neurosurgery services 5 (1.2) Number of CIHDOTTS 8 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Artenise Revoredo Phone: (84) 3232-7620 / 8839-8452 E-mail: cncdo@rn.gov.br Rio Grande do Norte has decreased slightly its numbers of potential and effective donations. Still the number of effective donors has not followed this tendency, mostly due to an increase in family refusal rate, accounting for 61% of all the interviews. ORGAN DONATION Effective donors: - pmp Northeast Rio Grande do Norte Number of effective donors 11 13 8 30 53 51 44 43 Number of effective donors (pmp) 3.6 4.3 2.7 9.5 16.7 16.1 13.9 13.6 Potential donors 100 73 90 103 143 151 177 174 Number of potential donors(pmp) 33.2 24.2 29.9 32.5 45.1 47.7 55.9 54.9 Non consenting families 24 18 21 36 53 65 73 68 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 54 61 57 Cardiopulmonary Arrest Unavailable 16 8 19 20 11 5 7 Medical Contraindications 45 21 42 13 7 8 18 19 Others 20 5 11 5 10 16 37 37 64

RIO GRANDE DO NORTE Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Northeast Rio Grande do Norte Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 2 3 2 2 1 1 1 2 LIVER 1 1 0 0 0 0 1 1 PANCREAS (not performed) HEART 2 1 1 1 0 0 0 0 Absolute number of transplants CORNEA 135 89 171 224 286 205 171 159 KIDNEY - total 30 34 15 52 51 54 52 69 living donor 8 11 5 8 11 9 5 9 deceased donor 22 23 10 44 40 45 47 60 LIVER 2 5 0 0 0 0 3 2 PANCREAS (not performed) HEART 2 1 1 3 0 0 0 0 Number of transplants pmp CORNEA 44.8 29.5 56.7 70.7 90.3 64.7 54.0 50.2 KIDNEY - total 10.0 11.3 5.0 16.4 16.1 17.0 16.4 21.8 living donor 2.7 3.6 1.7 2.5 3.5 2.8 1.6 2.8 deceased donor 7.3 7.6 3.3 13.9 12.6 14.2 14.8 18.9 LIVER 0.7 1.7 0.0 0.0 0.0 0.0 0.9 0.6 PANCREAS (not performed) HEART 0.7 0.3 0.3 0.9 0.0 0.0 0.0 0.0 65

RIO GRANDE DO SUL Population 10,693,929 (5.6%) Capital City: Porto Alegre 1,409,351 Area (Km²) 281,748.54 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 962 642 267 64 Performed transplants 710 555 142 9 Number of Mortality per year All Causes 75,305 73,996 76,788 77,985 80,148 79,456 Unavailable Unavailable External Causes 7,278 7,397 7,358 7,257 7,167 7,575 Unavailable Unavailable Neurological Causes 1,930 1,921 2,028 2,221 2,407 2,424 Unavailable Unavailable Population (census IBGE) 10,582,840 10,582,840 10,582,840 10,693,929 10,693,929 10,693,929 10,693,929 10,693,929 HOSPITALS % Nº Total 331 (5.4) State s capital 28 Country side 303 Nº of beds 33,400 (7.1) Nº of ICU beds 2260 (5.8) Hospitals over 80 beds 121 Teaching hospitals 15 Medical schools 15 (6.8) Neurosurgery services 28 (6.7) Number of CIHDOTTS 41 Number of OPOs 7 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Rosana Reis Nothen Phone/Fax: (51) 3353-3030 E-mail: centraldetransplantes@saude.rs.gov.br Rio Grande do Sul has a well-established transplantation program with a steady growth in the number of notifications since 2010 with an elevated number multiple organ transplants by donor. ORGAN DONATION Effective donors: - pmp Southeast Rio Grande do Sul Number of effective donors 147 132 126 133 158 194 201 214 Number of effective donors (pmp) 13.9 12.5 11.9 12.4 14.8 18.1 18.8 20.0 Potential donors 389 354 356 368 427 495 579 604 Number of potential donors(pmp) 36.8 33.5 33.6 34.4 39.9 46.3 54.1 56.5 Non consenting families 130 96 99 99 133 167 184 184 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 41 45 44 Cardiopulmonary Arrest Unavailable 88 88 88 94 81 113 114 Medical Contraindications 112 38 43 46 36 47 65 80 Others 0 0 0 2 6 6 16 12 66

RIO GRANDE DO SUL Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp DF Southeast Rio Grande do Sul Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 9 11 10 8 8 9 10 10 LIVER 6 6 7 6 5 5 6 6 PANCREAS 5 5 3 3 1 0 0 0 HEART 3 3 2 2 3 3 3 3 LUNG 1 1 2 1 2 2 2 2 Absolute number of transplants CORNEA 518 595 607 757 941 886 776 710 KIDNEY - total 375 325 339 400 468 548 545 555 living donor 124 110 106 114 94 97 70 79 deceased donor 251 215 233 286 374 451 475 476 LIVER 121 102 107 105 125 108 137 142 PANCREAS 21 18 7 4 1 0 0 0 HEART 8 14 9 5 11 11 12 9 LUNG 26 27 41 28 27 33 31 22 Number of transplants pmp CORNEA 48.9 56.2 57.4 70.8 88.0 82.9 72.6 66.4 KIDNEY - total 35.4 30.7 32.0 37.4 43.8 51.2 51.0 51.9 living donor 11.7 10.4 10.0 10.7 8.8 9.1 6.5 7.4 deceased donor 23.7 20.3 22.0 26.7 35.0 42.2 44.4 44.5 LIVER 11.4 9.6 10.1 9.8 11.7 10.1 12.8 13.3 PANCREAS 2.0 1.7 0.7 0.4 0.1 0.0 0.0 0.0 HEART 0.8 1.3 0.9 0.5 1.0 1.0 1.1 0.8 LUNG 2.5 2.6 3.9 2.6 2.5 3.1 2.9 2.1 67

RONDÔNIA Population 1,562,409 (0.8%) Capital City: Porto Velho 428,527 Area (Km²) 237,576.17 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 141 94 39 9 Performed transplants 23 11 0 0 Number of Mortality per year All Causes 5,565 6,289 6,837 7,225 7,014 7,602 Unavailable Unavailable External Causes 1,112 1,306 1,436 1,528 1,397 1,566 Unavailable Unavailable Neurological Causes 72 84 105 98 101 141 Unavailable Unavailable Population (census IBGE) 1,453,756 1,453,756 1,453,756 1,562,409 1,562,409 1,562,409 1,562,409 1,562,409 HOSPITALS % Nº Total 81 (1.3) State s capital 18 Country side 63 Nº of beds 4,008 (0.9) Nº of ICU beds 269 (0.7) Hospitals over 80 beds 14 Teaching hospitals 0 Medical schools 4 (1.8) Neurosurgery services 4 (1.0) Number of CIHDOTTS 3 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 CNCDO: Edcléia Gonçalves da Silva Phone: (69) 3216-5738 / 3216-5747 E-mail: gcetro@gmail.com Rondônia has recently started developing its organ donation program. In 2014 kidney and corneal transplants were performed. ORGAN DONATION Notified potential donors - pmp (not performed) Effective donors: - pmp North Rondônia Number of effective donors 2 10 10 10 Number of effective donors (pmp) 0.0 0.0 0.0 0.0 1.3 6.4 6.4 6.4 Potential donors 26 43 38 70 Number of potential donors(pmp) 0.0 0.0 0.0 0.0 16.6 27.5 24.3 44.8 Non consenting families 3 10 13 17 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 48 52 61 Cardiopulmonary Arrest Unavailable 2 0 3 0 Medical Contraindications 2 2 1 Others 19 21 10 42 68

RONDÔNIA Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp North Rondônia Liver - pmp (not performed) CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 1 LIVER (not performed) PANCREAS (not performed) HEART (not performed) Absolute number of transplants CORNEA 23 KIDNEY 11 living donor 1 deceased donor 10 LIVER (not performed) PANCREAS (not performed) HEART (not performed) Number of transplants pmp CORNEA 14.7 KIDNEY 7.0 living donor 0.6 deceased donor 6.4 LIVER (not performed) PANCREAS (not performed) HEART (not performed) 69

RORAIMA Population 450,479 (0.2%) Capital City: Boa Vista 284,313 Area (Km²) 224,298.98 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 41 27 11 3 Performed transplants 0 0 0 0 Number of Mortality per year All Causes 1,494 1,481 1,536 1,640 1,599 1,783 Unavailable Unavailable External Causes 385 337 351 372 350 419 Unavailable Unavailable Neurological Causes 18 23 14 29 22 40 Unavailable Unavailable Population (census IBGE) 395,725 395,725 395,725 450,479 450,479 450,479 450,479 450,479 HOSPITALS % Nº Total 12 (0.2) State s capital 6 Country side 6 Nº of beds 874 (0.2) Nº of ICU beds 37 (0.1) Hospitals over 80 beds 3 Teaching hospitals 0 Medical schools 1 (0.5) Neurosurgery services 2 (0.5) Number of CIHDOTTS 0 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 CNCDO: Douglas Henrique Teixeira Phone: 95-2121-0560/2121-0620 E-mail: direcaogeral.hgr@gmail.com Roraima has recently started developing its organ donation program. No transplants were communicated in 2014. ORGAN DONATION Notified potential donors - pmp (not performed) Effective donors: - pmp (not performed) North Roraima 2007 2008 2009 2010 2011 2012 2013 2013 Number of effective donors Number of effective donors (pmp) Potential donors Number of potential donors(pmp) Non consenting families Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable Cardiopulmonary Arrest Medical Contraindications Others 70

RORAIMA Organ Transplantation Kidney from deceased donor - pmp (not performed) Kidney from living donor - pmp (not performed) North Roraima Liver - pmp (not performed) CORNEA- pmp (not performed) Number of teams that performed transplantations during the year CORNEA (not performed) Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY (not performed) LIVER (not performed) PANCREAS (not performed) HEART (not performed) Absolute number of transplants CORNEA (not performed) KIDNEY (not performed) living donor deceased donor LIVER (not performed) PANCREAS (not performed) HEART (not performed) Number of transplants pmp CORNEA (not performed) KIDNEY (not performed) living donor deceased donor LIVER (not performed) PANCREAS (not performed) HEART (not performed) 71

SANTA CATARINA Population 6,248,436 (3.3%) Capital City: Florinanópolis 421,240 Area (Km²) 95,346.18 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 562 375 156 37 Performed transplants 729 293 113 4 Number of Mortality per year All Causes 32,102 31,869 33,825 34,474 35,912 35,435 Unavailable Unavailable External Causes 3,952 4,132 4,039 4,115 4,245 4,285 Unavailable Unavailable Neurological Causes 657 684 778 819 896 1,120 Unavailable Unavailable Population (census IBGE) 5,866,252 5,866,252 5,866,252 6,248,436 6,248,436 6,248,436 6,248,436 6,248,436 HOSPITALS % Nº Total 223 (3.7) State s capital 23 Country side 200 Nº of beds 16,620 (3.5) Nº of ICU beds 1020 (2.6) Hospitals over 80 beds 68 Teaching hospitals 7 Medical schools 9 (4.1) Neurosurgery services 22 (5.3) Number of CIHDOTTS 28 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Joel de Andrade Phone: (48) 3212-1612 / 3212-1613 E-mail: getra@saude.sc.gov.br Santa Catarina keeps on being the leading state in effective deceased donors pmp in, with well-established liver and kidney transplantation programs. ORGAN DONATION Effective donors: - pmp South Santa Catarina Number of effective donors 87 98 120 109 159 165 170 202 Number of effective donors (pmp) 14.8 16.7 20.5 17.4 25.4 26.4 27.2 32.3 Potential donors 257 244 277 295 384 386 416 469 Number of potential donors(pmp) 43.8 41.6 47.2 47.2 61.5 61.8 66.6 75.1 Non consenting families 104 70 94 91 94 111 115 134 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 40 39 37 Cardiopulmonary Arrest Unavailable 52 45 20 53 69 41 58 Medical Contraindications 37 13 8 71 74 32 40 56 Others 29 11 10 4 4 9 50 19 72

SANTA CATARINA Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp South Santa Catarina Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 7 6 7 6 5 5 6 6 LIVER 1 1 2 2 3 3 3 3 PANCREAS 0 1 2 1 1 1 1 1 HEART 2 1 1 0 0 0 1 1 Absolute number of transplants CORNEA 133 246 414 502 462 475 504 729 KIDNEY - total 182 216 256 227 272 245 270 293 living donor 30 46 40 52 51 40 42 33 deceased donor 152 170 216 175 221 205 228 260 LIVER 74 91 98 87 107 112 117 113 PANCREAS 0 4 8 6 9 5 12 7 HEART 3 2 1 0 0 0 4 4 Number of transplants pmp CORNEA 22.7 41.9 70.6 80.3 73.9 76.0 80.7 116.7 KIDNEY - total 31.0 36.8 43.6 36.3 43.5 39.2 43.2 46.9 living donor 5.1 7.8 6.8 8.3 8.2 6.4 6.7 5.3 deceased donor 25.9 29.0 36.8 28.0 35.4 32.8 36.5 41.6 LIVER 12.6 15.5 16.7 13.9 17.1 17.9 18.7 18.1 PANCREAS 0.0 0.7 1.4 1.0 1.4 0.8 1.9 1.1 HEART 0.5 0.3 0.2 0.0 0.0 0.0 0.6 0.6 73

SÃO PAULO Population 41,262,199 (21.6%) Capital City: São Paulo 11,253,503 Area (Km²) 248,209.43 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 3,714 2,476 1,032 248 Performed transplants 4,273 2,112 655 134 Number of Mortality per year All Causes 244,653 249,247 256,627 264,951 270,367 270,432 Unavailable Unavailable External Causes 23,241 23,837 24,048 24,151 24,276 25,041 Unavailable Unavailable Neurological Causes 5,998 5,845 6,508 7,182 7,615 7,894 Unavailable Unavailable Population (census IBGE) 39,827,570 39,827,570 39,827,570 41,262,199 41,262,199 41,262,199 41,262,199 41,262,199 HOSPITALS % Nº Total 898 (14.7) State s capital 199 Country side 699 Nº of beds 105,912 (22.6) Nº of ICU beds 10,909 (28.2) Hospitals over 80 beds 427 Teaching hospitals 43 Medical schools 41 (18.5) Neurosurgery services 112 (27.0) Number of CIHDOTTS 255 Number of OPOs 10 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO: Agenor Spallini Ferraz Phone: (11) 3064-1649 / 3088-5094 E-mail: ctrans@saude.sp.gov.br São Paulo leads in absolute numbers of transplants, accounting for more than 40% of the transplants performed in. The state transplant program was established in 1997 and keeps growing. ORGAN DONATION Effective donors: - pmp Southeast São Paulo Number of effective donors 376 486 705 872 793 757 802 824 Number of effective donors (pmp) 9.4 12.2 17.7 21.1 19.2 18.3 19.4 20.0 Potential donors 1,965 2,307 2,456 2,621 2,495 2,226 2366 2434 Number of potential donors(pmp) 49.3 57.9 61.7 63.5 60.5 53.9 57.3 59.0 Non consenting families 458 371 434 654 674 681 716 643 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 33 41 36 Cardiopulmonary Arrest Unavailable 859 706 480 374 368 401 401 Medical Contraindications 599 27 54 83 80 73 69 74 Others 532 564 557 532 574 347 378 492 74

SÃO PAULO Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Southeast São Paulo Liver - pmp CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 35 33 36 41 34 36 33 35 LIVER 24 21 20 23 22 22 22 26 PANCREAS 16 14 11 12 17 11 12 7 HEART 10 9 13 11 12 11 14 12 LUNG 1 2 2 2 2 2 2 2 Absolute number of transplants CORNEA 4,920 6,204 5,655 5,767 5,523 5,570 5,058 4,273 KIDNEY - total 1,361 1,512 1,801 2,063 2,014 1,959 1,928 2,112 living donor 791 799 764 659 674 602 526 594 deceased donor 570 713 1,037 1,404 1,340 1,357 1,402 1,518 LIVER 440 534 688 748 685 587 648 655 PANCREAS 110 125 124 99 120 77 74 66 HEART 49 72 92 76 69 78 103 134 LUNG 16 24 16 30 17 31 37 33 Number of transplants pmp CORNEA 123.5 155.8 142.0 139.8 133.9 135.0 122.6 103.6 KIDNEY - total 34.2 38.0 45.2 50.0 48.8 47.5 46.7 51.2 living donor 19.9 20.1 19.2 16.0 16.3 14.6 12.7 14.4 deceased donor 14.3 17.9 26.0 34.0 32.5 32.9 34.0 36.8 LIVER 11.0 13.4 17.3 18.1 16.6 14.2 15.7 15.9 PANCREAS 2.8 3.1 3.1 2.4 2.9 1.9 1.8 1.6 HEART 1.2 1.8 2.3 1.8 1.7 1.9 2.5 3.2 LUNG 0.4 0.6 0.4 0.7 0.4 0.8 0.9 0.8 75

SERGIPE Population 2,068,017 (1.1%) Capital City: Aracaju 571,149 Area (Km²) 21,910.35 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 186 124 52 12 Performed transplants 129 0 0 0 Number of Mortality per year All Causes 9,726 10,239 10,737 10,942 11,397 11,837 Unavailable Unavailable External Causes 1,339 1,457 1,641 1,781 1,764 1,955 Unavailable Unavailable Neurological Causes 134 159 193 192 194 249 Unavailable Unavailable Population (census IBGE) 1,939,426 1,939,426 1,939,426 2,068,017 2,068,017 2,068,017 2,068,017 2,068,017 HOSPITALS % Nº Total 45 (0.7) State s capital 18 Country side 27 Nº of beds 3,695 (0.8) Nº of ICU beds 355 (0.9) Hospitals over 80 beds 15 Teaching hospitals 1 Medical schools 2 (0.9) Neurosurgery services 2 (0.5) Number of CIHDOTTS 7 Number of OPOs 0 Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO:Benito Oliveira Fernandez Phone: (79) 3259-2899 / 3216-2870 E-mail: transplante@saude.se.gov.br Sergipe maintained the number of notifications of potential donors but the number of effective donors increased substantially although the rate of family refusal remains elevated. ORGAN DONATION Effective donors: - pmp Northeast Sergipe Number of effective donors 8 3 8 2 4 6 3 9 Number of effective donors (pmp) 4.1 1.5 4.1 1.0 1.9 2.9 1.5 4.4 Potential donors 34 26 42 33 44 97 111 110 Number of potential donors(pmp) 17.5 13.4 21.7 16.0 21.3 46.9 53.7 53.2 Non consenting families 16 5 5 10 15 43 49 45 Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable 77 89 78 Cardiopulmonary Arrest Unavailable 7 12 12 9 4 1 2 Medical Contraindications 10 3 17 7 7 14 30 25 Others 0 8 2 9 30 28 29 76

SERGIPE Organ Transplantation Kidney from deceased donor - pmp Kidney from living donor - pmp Northeast Sergipe Liver - pmp (not performed) CORNEA- pmp Number of teams that performed transplantations during the year CORNEA Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY 2 2 2 2 2 1 0 0 LIVER (not performed) PANCREAS (not performed) HEART (not performed) Absolute number of transplants CORNEA 58 59 104 84 130 144 120 129 KIDNEY - total 23 12 18 5 5 2 0 0 living donor 6 3 4 4 0 0 0 0 deceased donor 17 9 14 1 5 2 0 0 LIVER (not performed) PANCREAS (not performed) HEART (not performed) Number of transplants pmp CORNEA 29.9 30.4 53.6 40.6 62.9 69.6 58.0 62.4 KIDNEY - total 11.9 6.2 9.3 2.4 2.4 1.0 0.0 0.0 living donor 3.1 1.5 2.1 1.9 0.0 0.0 0.0 0.0 deceased donor 8.8 4.6 7.2 0.5 2.4 1.0 0.0 0.0 LIVER (not performed) PANCREAS (not performed) HEART (not performed) 77

TOCANTINS Population 1,383,445 (0.7%) Capital City: Palmas 228,332 Area (Km²) 277,620.91 Estimated annual need and number of transplants Cornea Kidney Liver Heart Estimated demand 125 83 35 8 Performed transplants 0 0 0 0 Number of Mortality per year All Causes 5,604 5,878 6,084 6,479 6,659 6,642 Unavailable Unavailable External Causes 946 954 1,051 1,185 1,211 1,236 Unavailable Unavailable Neurological Causes 81 80 93 123 126 131 Unavailable Unavailable Population (census IBGE) 1,243,627 1,243,627 1,243,627 1,383,445 1,383,445 1,383,445 1,383,445 1,383,445 HOSPITALS % Nº Total 63 (1.0) State s capital 11 Country side 52 Nº of beds 2,858 (0.6) Nº of ICU beds 190 (0.5) Hospitals over 80 beds 6 Teaching hospitals 0 Medical schools 6 (2.7) Neurosurgery services 3 (0.7) Number of CIHDOTTS Number of OPOs Source: http://cnes.datasus.gov.br 14/01/2015 http://emec.mec.gov.br/ 26/01/2015 Notified potential donors - pmp CNCDO:Donilda Moreira Rodrigues Phone: (63) 8107-3855 / 3218-3230 E-mail: transplantesto@yahoo.com.br ORGAN DONATION Effective donors: - pmp North Tocantins Number of effective donors Number of effective donors (pmp) Potential donors Number of potential donors(pmp) Non consenting families Percentage of rejection of interviews Unavailable Unavailable Unavailable Unavailable Unavailable Cardiopulmonary Arrest Medical Contraindications Others 78

Kidney from deceased donor - pmp (not performed) TOCANTINS Organ Transplantation Kidney from living donor - pmp (not performed) North Tocantins Liver - pmp (not performed) CORNEA- pmp (not performed) Number of teams that performed transplantations during the year CORNEA (not performed) Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable KIDNEY (not performed) LIVER (not performed) PANCREAS (not performed) HEART (not performed) Absolute number of transplants CORNEA (not performed) KIDNEY (not performed) living donor deceased donor LIVER (not performed) PANCREAS (not performed) HEART (not performed) Number of transplants pmp CORNEA (not performed) KIDNEY (not performed) living donor deceased donor LIVER (not performed) PANCREAS (not performed) HEART (not performed) 79

DATA PER TRANSPLANT CENTRE The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2013, name of person responsible for the team and record of the results ABTO History 80 City Name of the centre Performed Follow-up RBT - Evolution Person responsible 2014 Alagoas (3) AL Maceió Santa Casa de Misericordia de Maceió 21 13 José Wanderley Neto 3 Ceará (21) CE Fortaleza Hospital de Messejana 309 150 João David S Neto. Juan Alberto C Mejia 21 Distrito Federal (25) DF Brasília Instituto de Cardiologia do DF 96 96 Fernando Antibas Atik 25 Espírito Santo (7) ES Cariacica Hospital Meridional 34 14 Melchior Luiz Lima 7 Goiás (0) GO Goiânia Hospital Santa Genoveva 18 7 Wilson Luiz da Silveira 0 Minas Gerais (39) MG Belo Horizonte Hospital Clínicas UFMG 182 187 Maria Consolação Vieira Moreira 32 Belo Horizonte Hospital Felício Rocho 44 27 Marconi de Oliveira Ruas 7 Mato Grosso do Sul (0) MS Campo Grande Sociedade Beneficente, - Santa Casa 13 João Jasbik Neto 0 Pernambuco (25) PE Recife IMIP - Instituto de Medicina Integral Prof, Fernando Figueira 52 42 Carlos Roberto Ribeiro de Moraes 16 Recife Instituto do Heart de Pernambuco 144 55 Carlos Moraes. Fernando Moraes. Deuzeny Tenório Marques de Sá 9 Paraná (32) PR Campina Grande do Sul Sociedade Hospitalar Angelina Caron 84 23 Ricardo Alexandre Schneider 11 Curitiba Hospital Pequeno Príncipe 17 7 Fábio Saíd Sallum. Rita C R Silva 3 Curitiba Santa Casa de Misericórdia de Curitiba 171 87 Francisco Diniz Affonso da Costa 14 Londrina Santa Casa de Londrina 41 9 Arnaldo Akio Okino 3 Pato Branco Policlínica Pato Branco 16 4 Paulo Roberto Giublin 1 Rio de Janeiro (12) RJ Rio de Janeiro Hospital Pró-cardíaco 6 Alexandre Siciliano Colafranceschi 3 Rio de Janeiro Instituto Nacional de Cardiologia 51 28 Alexandre Siciliano Colafranceschi 9 Rio Grande do Norte (0) RN Natal Hospital do Heart de Natal 7 Marcelo Matos Cascudo 0 Rio Grande do Sul (9) RS Porto Alegre Fundação Universitária de Cardiologia 202 51 Ivo Abrahão Nesralla 5 Porto Alegre Hospital Clínicas Porto Alegre 27 7 Nadine Clausell 2 Porto Alegre Santa Casa de Misericordia 53 7 Fernando Antônio Lucchese 2 Santa Catarina (4) SC Frederico Jose Di Giovanni. Frederico Blumenau Hospital Santa Isabel 27 13 Jose Di Giovanni 4 São Paulo (134) SP Campinas UNICAMP - Univ, Estadual de Campinas 63 58 Orlando Petrucci Jr 5 Piracicaba Hospital dos Fornecedores de Cana 6 1 Marcus Vinicius Ferraz de Arruda 1 São José do Rio Preto FAMERP-FUNFARME-Hosp,Base 86 45 Marcelo J F Soares. Daniel F Villafanha 0 São Jose do Rio Preto FAMERP-FUNFARME-Hosp,Base 1 2 Ulisses A, Croti 0 São Paulo Hospital Beneficência Portuguesa 156 132 José Pedro da Silva 6 São Paulo Hospital Beneficência Portuguesa 4 1 Noedir Antonio Groppo Stolf 2 São Paulo Hospital do Heart -Assoc,Sanat,Sírio 6 3 Ênio Buffolo 1 São Paulo Hospital do Heart -Assoc,Sanat,Sírio 18 1 Jarbas Jakson Dinkhuysen 0 São Paulo Hospital do Heart -Assoc,Sanat,Sírio 1 1 Marcelo B Jatene 0 São Paulo Hospital Israelita Albert Einstein 23 13 Ênio Buffolo 0 São Paulo Hospital Israelita Albert Einstein 29 21 Fabio Biscegli Jatene 0 São Paulo Hospital Israelita Albert Einstein 20 18 Fernando Bacal 17 São Paulo Hospital Santa Catarina 1 João Nelson Rodrigues Branco 0 São Paulo Hospital Sírio-Libanês 13 10 Fabio Biscegli Jatene 9 São Paulo INCOR - Instituto do Heart 402 550 Fabio Biscegli Jatene 44 São Paulo INCOR - Instituto do Heart 160 75 Marcelo Jatene 24 São Paulo Instituto Dante Pazzanese Cardiologia 332 341 Paulo Chaccur 22 São Paulo UNIFESP - Hospital São Paulo/HKIDNEY 122 0 Walter José Gomes 1 Sorocaba Hospital Unimed Sorocaba 20 10 João Augusto Ferraz Sampaio 2 NI- Number of patients in follow-up was not informed Teams which informed 100% of the results of 2014 Transplants performed by the transplantation centre between 01/01/2014 and 31/12/2014. survival rates Follow up Patients with functional grafts, in follow-up at the transplantation centre

The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2014 (living donor / deceased), name of person responsible for the team and record of the results ABTO History Perfomed 2014 RBT - City Name of the centre Performed Follow-up Person responsible Living Deceased Total Evolution Acre (4) Rio Branco Fundação Hospital do Acre 4 4 Isamu Komatsu Lima 0 4 4 Amazonas (3) Manaus Fundação Hospitalar Adriano Jorge 3 Tercio Genzini 0 3 3 Bahia (53) Salvador Hospital São Rafael 111 15 Jorge Luiz Andrade Bastos 0 19 19 Salvador Real Soc, Portuguesa Beneficência 302 303 Jorge Luiz Andrade Bastos 0 34 34 Ceará (195) CE Fortaleza Hospital Geral de Fortaleza 186 124 Ivelise Regina Canito 0 43 43 Fortaleza Hospital São Carlos 37 31 José Huygens Parente Garcia 0 17 17 Fortaleza Hospital Univ, Walter Cantídio UFC 1018 746 José Huygens Parente Garcia 3 132 135 Distrito Federal(54) DF Brasília Hospital Brasília 16 13 Renato Ayroza Cury 0 6 6 Brasília Instituto de Cardiologia do DF 130 130 André Luis Watanabe 0 48 48 Espírito Santo (40) ES Cariacica Hospital Meridional 225 146 Gustavo Peixoto Soares Miguel 0 40 40 Serra Vitoria Apart Hospital 9 10 Vinicius Gomes da Silveira 0 0 0 Minas Gerais (91) Belo Horizonte Hospital Clínicas UFMG 878 Agnaldo Soares Lima 0 43 43 Belo Horizonte Hospital Felício Rocho 120 23 Silvério Leonardo Macedo Garcia 0 29 29 Belo Horizonte Hospital Lifecenter 9 7 Agnaldo Soares Lima 0 0 0 Belo Horizonte Hospital Mater Dei 27 13 Marcus E,V, Martins Costa 0 0 0 Montes Claros Irmandade N,Sra,Mercês 61 68 Luiz Fernando Veloso 0 19 19 Pará (0) PA Belem Hospital Porto Dias 1 1 Paulo Cardoso Soares 0 0 0 Paraíba (1) PB João Pessoa Hospital Unimed - Joao Pessoa 55 Cassio Virgilio C, de Oliveira 0 1 1 Pernambuco (115) PE AC AM BA MG Recife Hospital Jaime da Fonte 688 202 Cláudio Moura Lacerda 3 72 75 Recife Hospital Univ, Osvaldo Cruz 177 77 Cláudio Moura Lacerda 0 3 3 Recife Paraná (99) IMIP - Instituto de Medicina Integral Prof, Fernando Figueira 105 95 Cláudio Moura Lacerda 0 37 37 PR Campina Grande do Sul Soci Hospitalar Angelina Caron 152 47 João Eduardo Nicoluzzi 0 32 32 Curitiba Hosp, Clínicas Universidade Federal 476 525 Julio Cezar Uili Coelho 0 10 10 Curitiba Hospital N, Sra, das Graças 91 69 Julio C, U, Coelho. Eduardo J, B, Ramos 0 22 22 Curitiba Hospital Pequeno Príncipe 278 211 Julio Cesar Wiederkehr 4 3 7 Curitiba Hospital São Vicente de Curitiba 98 33 Marcial Carlos Ribeiro 0 28 28 Curitiba Santa Casa de Misericórdia 9 João Eduardo Nicoluzzi 0 0 0 Rio de Janeiro (188) RJ Itaperuna Hospital São José do Avaí 30 Renan Catharina Tinoco 0 2 2 Rio de Janeiro Centro Estadual de Transplantes 152 290 Lucio Pacheco 2 74 76 Rio de Janeiro Gavea Transplantes/Clín São Vicente 41 1 Silvio Martins 0 0 0 Rio de Janeiro Hospital Adventista Silvestre 210 150 Eduardo Fernandes 15 58 73 Rio de Janeiro Hospital da Criança 25 12 Lucio Pacheco 5 3 8 Rio de Janeiro Hospital Geral de Bonsucesso 498 383 0 0 0 Rio de Janeiro Hospital Quinta D'or 35 15 Lucio Pacheco 0 14 14 Rio de Janeiro Hospital Servidores do Estadual 5 6 0 0 0 Rio de Janeiro Hosp Univ, Clementino Fraga Filho 449 300 Rodrigo Martinez 0 15 15 NI- Number of patients in follow-up was not informed 2014 Transplants performed by the transplantation centre between 01/01/2014 and 31/12/2014. Follow up Patients with functional grafts, in follow-up at the transplantation centre Teams which informed 100% of the results of survival rates 81

The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2014 (living donor / deceased), name of person responsible for the team and record of the results ABTO History Perfomed 2014 RBT - City Name of the centre Performed Follow-up Person responsible Living Deceased Total Evolution Rio Grande do Norte(2) RN Natal Hospital do Heart de Natal 5 Alexandre Borges de Medeiros 0 2 2 Rio Grande do Sul (142) RS Caxias do Sul Hospital Geral de Caxias do Sul 3 0 Rafael Omar Pratavieira Giovanardi 0 0 0 Passo Fundo Hospital São Vicente de Paulo 222 98 Paulo Roberto Reichert 1 11 12 Porto Alegre Hospital Clínicas Porto Alegre 280 86 Cleber Dario Pinto Kruel 1 29 30 Porto Alegre Hospital Clínicas Porto Alegre 166 67 Sandra Maria Gonçalves Vieira 4 4 8 Porto Alegre Santa Casa de Misericordia 24 3 Antonio Nocchi Kalil. Cristina Targa Ferreira 3 0 3 Porto Alegre Santa Casa de Misericordia 1103 607 Maria Lucia Zanotelli. Guido P, C, Cantisani 1 82 83 Porto Alegre Santa Casa de Misericordia 71 46 Paulo Roberto Ott Fontes 0 6 6 Santa Catarina (113) SC Blumenau Hospital Santa Isabel 851 359 Marcelo Augusto Scheidemantel Nogara 0 95 95 Florianópolis Hospital Universitário 43 30 Mauro Rafael da Igreja 0 16 16 Joinville Hospital Municipal São José 13 13 Christian Evangelista Garcia 0 2 2 São Paulo (655) SP Botucatu Hospital Clínicas Fac, Medicina 13 6 Juan Carlos Llanos 0 0 0 Campinas UNICAMP - Univ, Estadual 683 244 Ilka de Fatima Santana Ferreira Boin 0 45 45 Ribeirão Preto Hospital das Clínicas da FMRP-USP 277 157 Orlando de Castro E Silva Jr, 0 30 30 São José do Rio Preto FAMERP-FUNFARME-Hosp,Base 442 182 Renato Ferreira da Silva 0 36 36 São José dos Campos Santa Casa Irmandade 132 133 Jorge Marcelo Padilla Mancero 0 36 36 São Paulo Hospital Alemão Oswaldo Cruz 101 6 Ben-Hur Ferraz Neto 0 3 3 São Paulo Hospital Alemão Oswaldo Cruz 36 9 Luiz Augusto Carneiro D' Albuquerque 0 4 4 São Paulo Hospital Alemão Oswaldo Cruz 70 4 Mauricio Fernando Almeida Barros 0 3 3 São Paulo Hospital Alemão Oswaldo Cruz 29 1 Sergio Mies 0 0 0 São Paulo Hospital Alemão Oswaldo Cruz 34 28 Tercio Genzini 0 1 1 São Paulo Hospital Beneficência Portuguesa 1 1 Andre Ibrahim David 0 1 1 São Paulo Hospital Beneficência Portuguesa 96 57 Ben-Hur Ferraz Neto 0 14 14 São Paulo Hospital Beneficência Portuguesa 4 3 Jorge Marcelo Padilla Mancero 0 4 4 São Paulo Hospital Beneficência Portuguesa 256 Luiz Augusto Carneiro D Albuquerque 0 0 0 São Paulo Hospital Beneficência Portuguesa 318 267 Marcelo Perosa de Miranda. Tercio Genzini 0 0 0 São Paulo Hospital Clínicas FMUSP 1351 686 Luiz Augusto Carneiro D'Albuquerque 5 100 105 São Paulo Hospital de Transplantes Euryclides de Jesus Zerbini 53 50 Adriano Miziara Gonzalez 0 12 12 São Paulo Hospital de Transplantes Euryclides de Jesus Zerbini 149 150 Carlos Eduardo Sandoli Baia 0 20 20 São Paulo Hospital do Câncer - A C Camargo 602 321 Eduardo Antunes da Fonseca 29 6 35 São Paulo Hospital Israelita Albert Einstein 1119 895 Marcio Dias de Almeida. Marcelo Bruno Rezende 0 125 125 São Paulo Hospital Nove de Julho 1 1 Carlos Eduardo Sandoli Baia 0 1 1 São Paulo Hospital Nove de Julho 16 4 Luiz Augusto Carneiro D'Albuquerque 0 1 1 São Paulo Hospital Samaritano - São Paulo 1 1 Andre Ibrahim David 0 0 0 São Paulo Hospital Samaritano - São Paulo 4 Marco Tulio Meniconi 0 1 1 São Paulo Hospital Sírio-Libanês 7 Luiz Augusto Carneiro D'Albuquerque 1 1 2 São Paulo Hospital Sírio-Libanês 362 169 Paulo Chap Chap 41 2 43 São Paulo Instituto da Criança Pedro de Alcântara 597 230 Uenis Tannuri 27 13 40 SÃO PAULO Insti, Dante Pazzanese Cardiologia 105 Sergio Mies 0 0 0 São Paulo Santa Casa de Misericordia 243 90 Paulo Celso Bosco Massarollo. Adriana Zuolo Coppini 0 6 6 São Paulo Sociedade Assistencial Bandeirantes 333 126 Tercio Genzini 5 54 59 São Paulo UNIFESP - Hospital São Paulo/ HKIDNEY 305 180 Adriano Miziara Gonzalez 0 27 27 Sorocaba Hospital Unimed Sorocaba 79 21 Ben-Hur Ferraz Neto 0 1 1 NI- Number of patients in follow-up was not informed Teams which informed 100% of the results of 2014 Transplants performed by the transplantation centre between 01/01/2014 and 31/12/2014. survival rates Follow up Patients with functional grafts, in follow-up at the transplantation centre 82

The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2014 (living donor / deceased), name of person responsible for the team and record of the results ABTO City Name of the centre History Realizado 2014 Pan Followup, Evolução Person responsible Kidney Kidney RBT- Pan/ após Pânc Performed Isolado Total Ceará (5) Fortaleza Hospital Geral de Fortaleza 39 20 Ronaldo de Matos Esmeraldo 5 0 0 5 Person Performed responsible Fortaleza Hosp, Univ, Walter Cantídio UFC 5 5 Gleydson Cesar de Oliveira Borges 0 0 0 0 Goiás (3) Goiâna Hospital Santa Genoveva 13 7 Braulio Ludovico Martins 3 0 0 3 Minas Gerais (19) Belo Horizonte Hospital Clínicas UFMG 39 32 CE GO MG Marcelo Dias Sanches. Agnaldo Soares Lima 2 0 0 2 Belo Horizonte Hospital Felício Rocho 246 231 Ricardo de Castro Gontijo 15 1 0 16 Belo Horizonte Santa Casa de Misericórdia de Belo Horizonte 4 Janice Sepúlveda Reis 1 0 0 1 Pernambuco (5) PE Recife IMIP - Instituto de Medicina Integral Prof, Fernando Figueira 11 11 Ruy de Lima Cavalcanti Neto 5 0 0 5 Paraná (21) PR Campina Grande do Sul Sociedade Hospitalar Angelina Caron 184 50 João Eduardo Nicoluzzi 19 0 2 21 Santa Casa de Misericórdia de Curitiba 16 João Eduardo Nicoluzzi 0 0 0 0 RS Curitiba Rio Grande do Sul (0) Porto Alegre Hospital Clínicas Porto Alegre 29 20 Roberto Ceratti Manfro 0 0 0 0 Porto Alegre Hospital São Lucas da PUC - 54 53 Marcelo Junges Hartmann 0 0 0 0 Porto Alegre Santa Casa de Misericordia 100 Valter Duro Garcia 0 0 0 0 Santa Catarina (7) SC Blumenau Hospital Santa Isabel 53 56 Luis Claudio Francalacci 5 2 0 7 São Paulo (66) SP Botucatu Hospital Clínicas Fac, Medicina 11 4 Leonardo Pelafsky 0 0 0 0 Ribeirão Preto Hospital Clínicas da FMRP-USP 8 6 José Sebastião Dos Santos 1 0 0 1 São José do Rio Preto FAMERP-FUNFARME-Hosp,Base 23 15 Paulo Cesar Arroyo Jr, 3 0 0 3 São Paulo Hospital Alemão Oswaldo Cruz 17 4 Emil Sabbaga 0 0 0 0 São Paulo Hospital Alemão Oswaldo Cruz 8 4 Irene de Lourdes Noronha 0 0 0 0 sao paulo Hospital Alemão Oswaldo Cruz 3 2 Joao Carlos Campagnari 0 0 0 0 São Paulo Hospital Alemão Oswaldo Cruz 5 3 Luiz Estevam Ianhez 0 0 0 0 São Paulo Hospital Alemão Oswaldo Cruz 39 51 Marcelo Perosa de Miranda 0 0 0 0 São Paulo Hospital Beneficência Portuguesa 54 34 Irene de Lourdes Noronha 2 0 0 2 São Paulo Hospital Beneficência Portuguesa 291 149 Tercio Genzini. Marcelo Perosa de Miranda 0 0 0 0 São Paulo Hospital Clínicas FMUSP 17 12 Luiz Augusto Carneiro D'Albuquerque 0 0 0 0 São Paulo Hospital Clínicas FMUSP 102 64 William Carlos Nahas 6 0 1 7 São Paulo Hospital de Transplantes Euryclides de Jesus Zerbini 1 Jose Medina Pestana 0 0 0 0 São Paulo Hospital Israelita Albert Einstein 162 7 Alvaro Pacheco E Silva Filho 1 0 0 1 São Paulo Santa Casa de Misericordia 8 2 Alcides Augusto Salzedas Netto 0 0 0 0 São Paulo Soc, Assistencial Bandeirantes 99 13 Marcelo Perosa de Miranda 12 14 1 27 São Paulo UNIFESP - Hospital São Paulo/ HKIDNEY 495 251 Jose Medina Pestana 23 1 1 25 NI- Number of patients in follow-up was not informed 2014 Transplants performed by the transplantation centre between 01/01/2014 and 31/12/2014. Follow up Patients with functional grafts, in follow-up at the transplantation centre Teams which informed 100% of the results of survival rates 83

The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2014 (living donor / deceased), name of person responsible for the team and record of the results ABTO 84 History Perfomed 2014 RBT - City Name of the centre Performed Follow-up Person responsible Living Deceased Total Evolution Acre (8) Rio Branco Fundação Hospital do Acre 60 62 Jarinne Camilo Landim Nasserala 3 5 8 Alagoas (26) AL Arapiraca Centro Hospitalar Manoel André - CHAMA 196 96 Maria do Carmo Teixeira 8 2 10 Maceió Fundação Hospital da Agro-Indústria do Açúcar e do Álcool de Alagoas 67 50 Fernando Melro Ressurreição 0 3 3 Maceió Hospital Memorial Arthur Ramos 3 Fernando Melro Resurreição 1 1 2 Maceió Santa Casa de Misericordia de Maceió 76 30 José D F Vaz. Arnon F Campos 5 6 11 Amazonas (22) AM Manaus Hospital Santa Júlia 424 365 Edson Sarkis Goncalves 10 12 22 Bahia (82) BA Itabuna Santa Casa de Misericordia de Itabuna 101 Neide Vinhático Pontes 1 17 18 Salvador Complexo Hospitalar Ana Neri-UFBA 215 220 Ricardo José Costa Mattoso 14 38 52 Salvador Hospital São Rafael 227 223 Paulo Benigno P, Batista 4 5 9 Salvador Real Soc, Espanhola de Beneficência 371 Ricardo José Costa Mattoso 0 1 1 Salvador Real Soc, Portuguesa de Beneficência 276 200 Ivo Coelho Silva 0 2 2 Ceará (283) CE Crato Fundação Leandro Bezerra de Menezes 199 217 Francisco Gilberto Pinheiro Rodrigues 1 10 11 Fortaleza Hospital Geral de Fortaleza 1765 1695 Ronaldo de Matos Esmeraldo 5 164 169 Fortaleza Hospital Monte Klinikum 6 José Anastácio Dias Neto 4 2 6 Fortaleza Hospital São Carlos 1 João B G Cerqueira. Regina C F G Garcia 1 0 1 Fortaleza Hospital Univ, Walter Cantídio UFC 1246 1200 Claudia M C de Oliveira. Paula F C B C Fernandes 2 94 96 Fortaleza Unimed de Fortaleza 5 Ronaldo Esmeraldo Matos 0 0 0 Distrito Federal (100) DF Brasília Hospital de Base do Distrito Federal 859 670 Maria Cristina S, de Gusmao Lobo 4 28 32 ia Hospital Regional Asa Norte HRAN 25 Sérgio Cavechia 0 0 0 Brasília Hospital Santa Lúcia - Brasília 37 4 Evandro Reis da Silva 1 0 1 ia Hospital Univ, Brasília 202 177 Giuseppe C Gatto. Romulo Maroccolo Filho 2 32 34 Brasília Instituto de Cardiologia do DF 48 48 Helen Souto Siqueira 3 30 33 Espírito Santo (88) ES Cachoeiro do Itapemirim Hospital Evangélico Cach, Itapemirim 25 Sérgio Damião S, Moraes 0 0 0 Cariacica Hospital Meridional 508 344 Lauro Vasconcellos 12 29 41 Serra Vitoria Apart Hospital 32 32 Paulo Anecio Paste 0 0 0 Vila Velha Hospital Evangélico de Vila Velha 488 640 Jose Nilton Amaral Torres 17 30 47 Vitória Hospital Univ, Cassiano Antonio de Moraes 200 199 Lauro Vasconcellos. Gustavo Lucio G Souza 0 0 0 Goias (65) GO Goiânia Hospital Geral de Goiânia 10 4 Alexandre Savio Oliveira de Freitas 0 2 2 Goiania Hospital Santa Genoveva 274 494 Bráulio Ludovico Martins 13 9 22 Goiania Santa Casa de Misericordia de Goiânia 53 24 Ramon Ramos Filho 9 9 18 Goiânia Santa Casa de Misericordia de Goiânia 760 325 Silvia Marçal Botelho 0 23 23 Maranhão (34) MA Imperatriz Hospital Santa Monica 5 5 Antonio Dantas Silva Junior 4 0 4 São Luis Hospital Univ, da UFMA 441 300 Teresa Cristina Alves Ferreira 12 18 30 Minas Gerais (588) MG Belo Horizonte Associação Evangélica Beneficente 267 159 Lilian Pires Freitas do Carmo 7 29 36 Belo Horizonte Fund Benjamin Guimarães - Hosp da Baleia 80 77 Cristiane Nahas Camargos 5 9 14 Belo Horizonte Hospital Clínicas UFMG 657 865 Fernando Lucas Junior 3 12 15 Belo Horizonte Hospital Felício Rocho 1390 Sandra Simone Vilaça 30 72 102 Belo Horizonte Hospital Mater Dei 39 36 Euler Pace Lasmar. Marcus E,V, M Costa 6 0 6 Belo Horizonte Hospital São Francisco de Assis 619 8 Geraldo Majella M,De Paula 4 3 7 Belo Horizonte Hospital Universitário São Jose 417 559 Euler Pace Lasmar. Marcus Faria Lasmar 40 35 75 Belo Horizonte Hospital Vera Cruz 176 541 Eduardo Roberto da Silveira 0 0 0 Belo Horizonte Santa Casa de Misericórdia 458 404 Andre Barreto Pereira 28 56 84 NI- Number of patients in follow-up was not informed 2014 Transplants performed by the transplantation centre between 01/01/2014 and 31/12/2014. Follow up Patients with functional grafts, in follow-up at the transplantation centre AC Teams which informed 100% of the results of survival rates

The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2014 (living donor / deceased), name of person responsible for the team and record of the results ABTO History Perfomed 2014 RBT - City Name of the centre Performed Follow-up Person responsible Living Deceased Total Evolution Divinópolis Hospital São João de Deus 151 107 Vania Cristina Ferreira 0 5 5 Ipatinga Hospital Márcio Cunha 346 228 Carlos Alberto Chalabi Calazans 21 19 40 Juiz de Fora Hospital Dr, João Felício 176 151 Adriano Morone Braga 0 0 0 Juiz de Fora Santa Casa de Misericórdia de Juiz de Fora 493 225 Sebastião Ferreira 24 53 77 Montes Claros Irmandade N,Sra,Mercês de Montes Claros 545 555 Geraldo Sergio Goncalves Meira 9 40 49 Nova Lima Biocor - Hosp, Doenças Cardiovasculares 138 224 Hélcio Antonio Tavares Filho 2 2 4 Pouso Alegre Hospital Clínicas Samuel Libanio 146 147 Yara Garcia Lorena 1 29 30 Uberaba Hosp Clínicas Fac, Med,Triângulo Mineiro 171 67 Vilmar Paiva Marques 1 3 4 Uberlândia Hospital de Clínicas de Uberlândia - FAEPU 304 Eduardo Henrique M, Braga 2 14 16 Uberlândia Hospital Santa Catarina - Uberlândia 233 151 Marcus Vinicius P, Netto 3 21 24 Mato Grosso do Sul (0) MS Campo Grande Sociedade Benef,- Santa Casa 599 Jose Carlos Martins Costa 0 0 0 Campo Grande Sociedade Benef,- Santa Casa 65 45 Mirian Sandri de Oliveira Trentin 0 0 0 Pará (50) PA Belém Hospital Ofir Loyola 495 485 Jose Ricardo Tuma da Ponte 2 35 37 Belém Hospital Saúde da Mulher 5 Silvia Regina da Cruz Migone 0 2 2 Redenção Hospital Regional Público do Araguaia 26 26 Juliano Sacramento Mundim 11 0 11 Paraíba (39) PB Campina Grande Hospital Antonio Targino 213 173 Rafael Fábio Maciel. Ana Valeria Lustosa Benicio Moraes 22 17 39 João Pessoa Hospital São Vicente de Paulo 26 Washington Ciro da Silva 0 0 0 João Pessoa Hospital Unimed - Joao Pessoa 11 11 Cristianne da Silva Alexandre 0 0 0 Pernambuco (279) PE Caruaru Casa de Saude Santa Efigenia 326 259 Jose Abilio Alves de Oliveira Neto. Willna Lôla Mendes Vilar 0 20 20 Recife Hospital Clínicas UF Pernambuco 94 Alexandre de Souza Guedes 5 0 5 Recife Hospital Esperança 29 6 Francisco Leandro Araujo Junior 0 0 0 Recife Hospital Jaime da Fonte 2 José Aureliano Carneiro Pires 1 0 1 Recife Hospital Memorial São José 10 Mario Henrique de Oliviera Junior 0 0 0 Recife IMIP - Instituto de Medicina Integral Prof, Fernando Figueira 873 680 Luis Gonzaga de Negreiros Filho 7 160 167 Recife Real Hosp, Português Benef, Pernambuco 786 239 Frederico Castelo Branco Cavalcanti 13 73 86 Piaui (35) PI Teresina Casa de Saúde Mat,Teresina - Casamater 384 108 Avelar Alves da Silva 9 11 20 Teresina Hospital Getúlio Vargas 58 62 Celina Teresa C Branco Couto de Sousa 4 11 15 Teresina Hospital Santa Maria - Teresina 157 Luis Carlos Feitosa Tajra 0 0 0 Paraná (432) PR Campina Grande do Sul Sociedade Hospitalar Angelina Caron 197 42 Carlos Gustavo Marmanillo 17 30 47 Campina Grande do Sul Sociedade Hospitalar Angelina Caron 142 84 Fabiola Pedron Peres da Costa. João Eduardo Nicoluzzi 16 27 43 Cascavel Hospital N, Sra, Salete 169 169 Hi Kyung Ann 8 5 13 Curitiba Hospital da Cruz Vermelha eira 296 170 Ronaldo Moreno de Carvalho 18 3 21 Curitiba Hospital Pequeno Príncipe 300 120 Antonio E Silveira. Mariana F M Cunha 3 18 21 Curitiba Hospital São Vicente de Curitiba 128 110 Luciana Soares Percegona 11 19 30 Curitiba Hospital Univ, Cajuru 358 331 Alexandre Tortoza Bignelli 23 32 55 Curitiba Hospital Universitário Evangélico 1217 750 Fabiana L C Contieri. Alexandre T Bignelli 26 33 59 Curitiba Santa Casa de Misericórdia de Curitiba 569 396 Sérgio G Marks. Fabiola P Peres da Costa 11 9 20 Londrina Hospital Evangélico de Londrina 267 800 6 8 14 Londrina Santa Casa de Londrina 184 90 Getúlio M, Amaral 4 9 13 Maringa Associacao Beneficente Bom Samaritano 116 71 Adaelson A, Silva 12 29 41 Maringá Santa Casa de Misericordia de Maringá 174 105 Sérgio Seiji Yamada 5 11 16 Pato Branco Policlínica Pato Branco 577 288 Magnus Engel. Jorge Ramos. Daniel Emygdio Nascimento 18 21 39 Umuarama Assoc, Benef, de Saude do Noroeste do Paraná - NOROSPAR 98 124 NI- Number of patients in follow-up was not informed 2014 Transplants performed by the transplantation centre between 01/01/2014 and 31/12/2014. Follow up Patients with functional grafts, in follow-up at the transplantation centre Sandra Mara Oliver Martins Aguilar. Henrique Gorla Neto 0 0 0 Teams which informed 100% of the results of survival rates 85

The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2014 (living donor / deceased), name of person responsible for the team and record of the results ABTO 86 History Perfomed 2014 RBT - City Name of the centre Performed Follow-up Person responsible Living Deceased Total Evolution Rio de Janeiro (468) RJ Campos de Goytacazes Hosp, Dr,Beda - Instituto Med,Nuclear de Campos 80 57 João Carlos Borromeu Piraciaba 0 0 0 Campos de Goytacazes Hospital Escola Álvaro Alvim 45 36 Luiz Eduardo Castro de Oliveira 0 0 0 Itaperuna Hospital São José do Avaí 22 Victor Maurílio Pinto Bastos 0 0 0 Niterói Hospital de Clínicas Niterói 117 117 Alan Castro Azevedo E Silva 5 5 10 Niterói Hospital de Clínicas Niterói 26 15 Paulo Alexandre Menezes 6 0 6 Niterói Hospital de Clínicas Niterói 54 Renato Torres Gonçalves 0 0 0 Niterói Hospital Univ, Antonio Pedro 228 164 Jocemir R, Lugon 0 22 22 Rio de Janeiro Centro Estadual de Transplantes 349 449 Deise R,B,Monteiro Carvalho 12 196 208 Rio de Janeiro Gavea Transplantes/ Clínica São Vicente 4 0 0 0 Rio de Janeiro Hospital Adventista Silvestre 159 160 Pedro Tulio Rocha 42 2 44 Rio de Janeiro Hospital da Criança no Rio de Janeiro 9 Regina de Novaes 0 8 8 Rio de Janeiro Hospital Geral de Bonsucesso 1858 2217 Alvaro Modesto Borela 16 117 133 Rio de Janeiro Hospital Quinta D'or 12 11 Elizabeth Maccariello 1 1 2 Rio de Janeiro Hospital São Vicente de Paulo 143 114 Deise R,B,Monteiro Carvalho 2 0 2 Rio de Janeiro Hospital Servidores do Est, Rio de Janeiro 66 686 Aderbal de Sousa Cypriano Neves 0 0 0 Rio de Janeiro Hospital Univ, Clementino Fraga Filho 959 Renato Torres Gonçalves 2 0 2 Rio de Janeiro Hospital Univ, Pedro Ernesto 768 613 Jose Cavaliere Sampaio 8 23 31 Rio Grande do Norte (69) RN Natal Hospital do Heart de Natal 68 47 Kellen Micheline Alves Henrique Costa 0 3 3 Natal Hospital Univ, Onofre Lopes 442 420 Jose Bruno de Almeida 9 57 66 Rio Grande do Sul (555) RS Caxias do Sul Hospital N, Sra, Pompéia 189 1 Luciana do Amaral Leonardelli 0 8 8 Ijuí Associação Hospital de Caridade de Ijuí 91 61 Maria Leocádia Bernardes do Amaral Padilha 4 5 9 Lageado Hospital Bruno Born 37 14 Ernany Vicente Bender Júnior 0 9 9 Passo Fundo Hospital São Vicente de Paulo - Passo Fundo 181 Péricles Serafin Sarturi 3 9 12 Pelotas Hospital Universitario Sao Francisco de Paula 6 5 Franklin Correa Barcellos 1 2 3 Porto Alegre Hospital Clínicas Porto Alegre 1468 1090 Roberto Ceratti Manfro 14 115 129 Porto Alegre Hospital Mae de Deus - AESC 28 21 Rodrigo Fontanive Franco 3 5 8 Porto Alegre Hospital São Lucas da PUC - Porto Alegre 1105 390 Moacir Traesel. David Saitovitch. Leonardo Viliano Kroth 11 95 106 Porto Alegre Santa Casa de Misericordia de Porto Alegre 3091 1400 Valter Duro Garcia. Clotilde Druck Garcia 38 212 250 Santa Maria Hospital Univ, Santa Maria 249 155 Luiz Alberto Michet da Silva 5 16 21 Rondônia (11) RO Porto Velho Hospital de Base Dr, Ary Pinheiro 11 11 Alessandro Correa Prudente Dos Santos 1 10 11 Santa Catarina (293) SC Blumenau Hospital Santa Isabel 866 965 Denise R, Pedroso 9 95 104 Chapecó Hospital Reg, Lenoir Vargas Ferreira 220 187 Antonio Cesar Mosqueta 6 20 26 Florianópolis Hospital de Caridade 287 227 Luciane Terezinha Ramlow 3 28 31 Florianópolis Hospital Governador Celso Ramos 211 189 Carla Wood Schmitz 3 21 24 Joinville Hospital Dona Helena - Joinville 4 3 Jose Aluisio Vieira. Hercilio A Luz Filho 0 0 0 Joinville Hospital Municipal São José 1037 720 Luciane M Deboni. Hercilio A Luz Filho 12 79 91 Joinville Hospital Municipal São José 68 Osmar Sérgio Hausen 0 0 0 Joinville Hospital Reg,Hans Dieter Schmidt 165 19 Hercilio A Luz Filho. Luciane M Deboni 0 17 17 Sergipe (0) SE Aracaju Hospital São Lucas 58 23 Manoel Pacheco de Andrade Júnior 0 0 0 Aracaju Hospital São Lucas 52 Ricardo Jose Vianna de Bragança 0 0 0 São Paulo (2,112) SP Bauru Associação Hospitalar de Bauru 105 80 Tereza M, S, Faifer 0 0 0 Botucatu Hospital Clínicas Fac, Medicina de Botucatu 918 609 M, Fernanda C, Carvalho 23 96 119 Campinas UNICAMP - Univ, Estadual de Campinas 1771 1330 Marilda Mazzali 22 97 119 Marilia Santa Casa de Misericordia de Marília 458 163 Jose Cicero Guilhen 2 20 22 Piracicaba Hospital dos Fornecedores de Cana 1 1 José Eduardo Vergueiro Neves Jr, 0 0 0 Presidente Prudente Santa Casa de Misericordia 194 77 Haroldo Pedrini 0 7 7 Ribeirão Preto Hospital das Clínicas da FMRP-USP 926 485 Sílvio Tucci Jr, 6 44 50 Ribeirão Preto Hospital São Francisco 244 139 Maria Estela Papini Nardin 0 0 0 NI- Number of patients in follow-up was not informed 2014 Transplants performed by the transplantation centre between 01/01/2014 and 31/12/2014. Follow up Patients with functional grafts, in follow-up at the transplantation centre Teams which informed 100% of the results of survival rates

The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2014 (living donor / deceased), name of person responsible for the team and record of the results ABTO History Perfomed 2014 RBT - City Name of the centre Performed Follow-up Person responsible Living Deceased Total Evolution Ribeirão Preto Santa Casa de Ribeirão Preto 105 52 Gilberto Saber. Luciana Tanajura Santamaria Saber 6 12 18 São Bernardo do Campo Fundação do ABC Hosp, Univ, MEC/MPAS 42 36 Ronaldo Roberto Bergamo 0 0 0 São José do Rio Preto FAMERP-FUNFARME-Hosp,Base S,J,R,Preto 682 250 Mario Abbud Filho. Horácio Jose Ramalho 7 45 52 São José do Rio Preto Instituto Urologia e Nefrologia 663 Mário Abbud Filho 8 27 35 São Paulo Hospital Alemão Oswaldo Cruz 404 100 Flavio Jota de Paula 0 0 0 São Paulo Hospital Alemão Oswaldo Cruz 13 6 Irene de Lourdes Noronha 0 1 1 Sao Paulo Hospital Alemão Oswaldo Cruz 34 1 Joao Carlos Campagnari 5 0 5 Sao Paulo Hospital Alemão Oswaldo Cruz 8 Jose Osmar Medina Pestana 1 0 1 Sao Paulo Hospital Alemão Oswaldo Cruz 13 3 Luiz Estevam Ianhez 1 0 1 São Paulo Hospital Alemão Oswaldo Cruz 36 3 Pedro Renato Chocair 0 4 4 São Paulo Hospital Beneficência Portuguesa 410 771 Anita Saldanha 29 2 31 São Paulo Hospital Beneficência Portuguesa 41 34 Irene de Lourdes Noronha 14 16 30 Sao Paulo Hospital Beneficência Portuguesa 87 52 Irina Antunes 0 0 0 São Paulo Hospital Beneficência Portuguesa 786 770 João Carlos Campagnari 12 2 14 São Paulo Hospital Beneficência Portuguesa 13 11 Luiz Estevam Ianhez 0 1 1 São Paulo Hospital Clínicas FMUSP 2934 1307 William Carlos Nahas 75 180 255 São Paulo Hospital de Transplantes Euryclides de Jesus Zerbini 377 302 Jose Medina Pestana 0 59 59 São Paulo Hospital Israelita Albert Einstein 1016 916 Alvaro Pacheco Silva E Filho 41 62 103 São Paulo Hospital Israelita Albert Einstein 6 2 Irene de Lourdes Noronha 1 0 1 São Paulo Hospital Nove de Julho 1 1 Irene de Lourdes Noronha 0 0 0 São Paulo Hospital Nove de Julho 1 1 Joao Carlos Campagnari 0 0 0 São Paulo Hospital Nove de Julho 10 10 Zita Maria Leme Brito 0 2 2 São Paulo Hospital Samaritano - São Paulo 222 225 Jose Carlos C, Baptista-Silva 8 48 56 São Paulo Hospital Samaritano - São Paulo 187 187 Patricia Malafronte 29 22 51 São Paulo Hospital Santa Cruz 45 35 João Américo da Fonseca. Geraldo de Campos Freire 4 0 4 São Paulo Hospital Santa Marcelina 873 818 Auro Buffani Claudino 14 11 25 São Paulo Hospital Servidor Público Fco M, Oliveira 175 126 Savina Adriana Bobbio 0 0 0 São Paulo Hospital Sírio-Libanês 271 142 Elias David-Neto 6 3 9 São Paulo Hospital Sírio-Libanês 13 Paulo Cesar Ayrosa Galvão 1 0 1 São Paulo Instituto Dante Pazzanese Cardiologia 434 510 João Moreira 6 28 34 São Paulo Santa Casa de Misericordia de São Paulo 138 30 Vanda Benini 1 0 1 São Paulo Santa Casa de Misericordia de São Paulo 268 339 Yvoty Alves Santos Sens 8 15 23 São Paulo Sociedade Assistencial Bandeirantes 129 26 Luiz Estevam Ianhez 26 15 41 São Paulo Sociedade Assistencial Bandeirantes 475 431 Paulo Sergio Luconi 14 16 30 São Paulo UNIFESP - Hospital São Paulo/HKIDNEY 11020 6495 Jose Medina Pestana 222 669 891 Sorocaba Fund Sao Paulo - Hospital Santa Lucinda 109 114 Francisco Antonio Fernandes 2 14 16 History Perfomed 2014 RBT - City Name of the centre Performed Follow-up Person responsible Living Deceased Total Evolution Ceará (11) CE Fortaleza Hospital de Messejana 27 27 Antero Gomes Neto 0 11 11 Distrito Federal (0) DF Brasília Instituto de Cardiologia do DF 2 2 Claudio Ribeiro da Cunha 0 0 0 Minas Gerais (2) MG Belo Horizonte Hospital Clínicas UFMG 21 5 Nilson Figueiredo Amaral 0 1 1 Rio Grande do Sul (22) RS Porto Alegre Hospital Clínicas Porto Alegre 10 5 Amarílio Vieira de Macedo Neto 0 2 2 Porto Alegre Santa Casa de Misericordia 472 Jose de Jesus Peixoto Camargo 1 19 20 São Paulo (33) SP São Paulo Hospital Israelita Albert Einstein 26 23 Paulo Manuel Pêgo Fernandes 0 5 5 São Paulo INCOR - Instituto do Heart 241 118 Paulo Manuel Pêgo Fernandes 0 28 28 NI- Number of patients in follow-up was not informed 2014 Transplants performed by the transplantation centre between 01/01/2014 and 31/12/2014. Follow up Patients with functional grafts, in follow-up at the transplantation centre Teams which informed 100% of the results of survival rates 87

The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2014, name of person responsible for the team and record of the results ABTO THE SUM OF CORNEAL TRANSPLANTS FOR SOME TEAMS MAY NOT CONFER WITH THE TOTAL SENT BY THE CENTRAL STATE City Name of centre RBT - Evolution Person responsible Acre (25) (number of performed transplants not informed) Alagoas (90) (number of performed transplants not informed) Amazonas (187) (number of performed transplants not informed) Bahia (332) (number of performed transplants not informed) Ceará (786) Fortaleza Clinica Neusa Rocha Marineuza Rocha Memória 60 Distrito Federal (351) DF Brasília Instituto de Cardiologia do DF Renata Leal Barbosa Bettarello 35 Espírito Santo (308)(number of performed transplants not informed) ES Goiás (735) GO Goiânia Fundação Banco de Olhos de Goiás Zander Campos da Silva 429 Maranhão (107) (number of performed transplants not informed) MA Minas Gerais (1419) MG Alfenas Santa Casa de Misericordia de Passos Patrick Jones Figueiredo 15 Belo Horizonte Associação Evangélica Beneficente Gustavo Heleno Albuquerque Temponi 26 Belo Horizonte Bio Visão - Centro Esp, Microcir, Ocular Renato Cruz Laender 14 Belo Horizonte Centro de Oftalmologia Avançada Eduardo Adam França Alves 52 Belo Horizonte Centro de Oftalmologia Avançada Marcelo Mendes F, Lemos 8 Belo Horizonte Centro de Oftalmologia Avançada Ronaldo Mendonca Badaro 1 Belo Horizonte Centro Oftalmológico de Minas Gerais Bruno Castelar 3 Belo Horizonte Centro Oftalmológico de Minas Gerais Carlos Gustavo Queiroz 116 Belo Horizonte Centro Oftalmológico de Minas Gerais Guilherme Hermeto de Almeida Cunha 15 Belo Horizonte Centro Oftalmológico de Minas Gerais Rafael Canhestro Neves. Anna Christina Higino Rocha 100 Belo Horizonte Centro Oftalmológico de Minas Gerais Reinaldo de Oliveira Sieiro. Patrícia Dias Fernandes 1 Belo Horizonte Centro Oftalmológico de Minas Gerais Sandro Coscarelli 7 Belo Horizonte Centro Oftalmológico de Minas Gerais Sérgio S Guimarães. Fernando M M Malheiros 10 Belo Horizonte Clínica de Olhos Ennio Coscarelli Sandro Antonini Coscarelli. Umberto Antonini Rizzuto 133 Belo Horizonte Clínica de Olhos Paulo Ferrrara Paulo Ferrara. Henrique Vizibelli 16 Belo Horizonte Clínica Fernando Trindade Fernando Cançado Trindade 3 Belo Horizonte Fundação Hilton Rocha Wagner Gomes Dias 93 Belo Horizonte Hospital Clínicas UFMG Joel Edmur Boteon 69 Belo Horizonte Hospital de Olhos de Minas Gerais Leonardo Romano Tiburcio 28 Belo Horizonte Hospital Universitário São Jose Bruno Lovaglio Cançado Trindade 10 Belo Horizonte Instituto da Visão Márcio Nehemy Lúcio Galvão Dantas. Márcio Nehemy 3 Belo Horizonte Instituto de Olhos de B, Horizonte Guilherme K, Munhoz 16 Belo Horizonte Instituto Mineiro de Olhos - IMOL Marcelo Miranda. Evandro Ribeiro Diniz 7 Belo Horizonte Instituto Vizibelli Henrique Vizibelli Chaves 4 Belo Horizonte Núcleo de Oftalmologia Especializada Frederico Pereira. Marcelo Mendes. João Ângelo Mirando Siqueira. Guilherme Mourão Soares da Rocha 14 Belo Horizonte Núcleo de Oftalmologia Especializada Joel Edmur Boteon. Eduardo Adan França Alves 27 Belo Horizonte Núcleo de Oftalmologia Especializada Marco Tanure. Gustavo F C Almeida. Roberto Márcio de Oliveira Santos 19 Belo Horizonte Núcleo de Oftalmologia Especializada Patrícia Dias. Rogério A, Tácia 8 Belo Horizonte Oftalmoclínica Rui Marinho Rui Menezes Marinho 1 Belo Horizonte Santa Casa de Misericórdia de Belo Horizonte Gilberto Guimarães Freitas 110 Belo Horizonte Santa Casa de Misericórdia de Belo Horizonte Umberto Antonini Rizzuto 8 Carango Casa de Caridade de Carango Claudio Luiz. Fabio Morando 4 Cataguases Hospital de Cataguases Arlex Brisceno 3 Cataguases Hospital de Cataguases Marcelo de Souza Bogado 9 Contagem Instituto Mineiro de Olhos - IMOL Lúcio Galvão Dantas 37 Governador Valadares Beneficência Social Bom Samaritano Guilherme F Pascoal. Victor F Masson. Poliana D Pires 5 Governador Valadares Hospital de olhos de Governador Valadares Celso Resende Costa 22 Ipatinga Hospital de Olhos Vale do Aço Altair Rosa 10 Juiz de Fora Santa Casa de Misericórdia de Juiz de Fora Dayana Kneipp 55 Montes Claros Irmandade N,Sra,Mercês de Montes Claros Bruno Picanço 18 Montes Claros Irmandade N,Sra,Mercês de Montes Claros Luciano Solia Nasser 2 Pouso Alegre Fund de Ensino Superior do Vale do Sapucaí Carlos Augusto Tiburzino Rezende 3 Pouso Alegre Fund de Ensino Superior do Vale do Sapucaí Carlos Henrique de Toledo Magalhães 3 Pouso Alegre Hospital Clínicas Samuel Libanio Carlos Henrique de Toledo Magalhães 4 Uberaba Hospital Clínicas Fac, Med,Triângulo Mineiro Hélio Massa. Helia Soares Angotti 32 Uberaba Oftalmocentro Helia Soares Angotti 11 Uberlandia Centro Oftalmologico de Uberlandia Jose Marcos S, Goncalves 4 Uberlândia Hospital de Clínicas de Uberlândia - FAEPU Flávio Jaime Rocha 53 Uberlandia Hospital de Olhos Central Flávio Jaime Rocha. Hamilton Barreiros 14 Uberlândia Hospital Santa Catarina - Uberlândia Lauro Panucci. Guilherme Ferreira Lima 4 Uberlândia ISO - Instituto de Saúde Ocular Mário José Carvalho 33 AC AL AM BA CE performed 2014 88

The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2014, name of person responsible for the team and record of the results ABTO THE SUM OF CORNEAL TRANSPLANTS FOR SOME TEAMS MAY NOT CONFER WITH THE TOTAL SENT BY THE CENTRAL STATE performed City Name of centre RBT - Evolution Person responsible 2014 Mato Grosso do Sul (139) (number of performed transplants not informed) MS Mato Grosso (116) (number of performed transplants not informed) MT Pará (212) (number of performed transplants not informed) PA Paraíba (140) (number of performed transplants not informed) PB Pernambuco (759) (number of performed transplants not informed) PE Piaui (195) (number of performed transplants not informed) PI Paraná (811) PR Cascavel Hospital de Olhos de Cascavel Selma Miyazaki. Darci Dacome 56 Cascavel Instituto da Visao de Cascavel Norisvaldo Cesar Bressanim 105 Curitiba Santa Casa de Misericórdia de Curitiba Francisco Grupenmacher 29 Londrina Hospital de Olhos de Londrina Nobuaqui Hasegawa 84 Rio de Janeiro (301) (number of performed transplants not informed) RJ Rio Grande do Norte (159) (number of performed transplants not informed) RN Rio Grande do Sul (710) RS Caxias do Sul Hospital Geral de Caxias do Sul Eduardo Della Giustina 17 Caxias do Sul Hospital N, Sra, Pompéia Roberto Conte 25 Passo Fundo Hospital São Vicente de Paulo - Passo Fundo Eduardo Ventura 54 Porto Alegre Hospital Banco de Olhos de Porto Alegre Roberto Freda 13 Porto Alegre Hospital Clínicas Porto Alegre Sérgio Kwitko 215 Porto Alegre Santa Casa de Misericordia de Porto Alegre Ítalo Mundialino Marcon 85 Rondônia (23) (number of performed transplants not informed) RO Santa Catarina (729) (number of performed transplants not informed) SC Sergipe (129) (number of performed transplants not informed) SE São Paulo (4273) SP Campinas UNICAMP - Univ, Estadual de Campinas Rosane Silvestre de Castro 73 São José do Rio Preto FAMERP-FUNFARME-Hosp,Base S,J,R,Preto Marta Ferrari Teixeira 38 São José do Rio Preto FAMERP-FUNFARME-Hosp,Base S,J,R,Preto Renata Tiemi Hashiwabuchi 17 São José dos Campos Centro Oftalmologico Dr,Syogi Shinzato Syogi Shinzato 6 São Paulo Clínica de Olhos Dr, Moacir Cunha Marcelo Cunha 7 São paulo Hospital Alemão Oswaldo Cruz Edson Kasuo Ando 6 São Paulo Hospital Israelita Albert Einstein Claudio Luiz Lottenberg 29 São Paulo Hospital Israelita Albert Einstein Jose Alvaro Pereira Gomes 1 São Paulo Hospital Israelita Albert Einstein Luciene Barbosa de Sousa 5 São Paulo Hospital Israelita Albert Einstein Marcelo Carvalho Cunha 7 São Paulo Hospital Israelita Albert Einstein Samir Bechara 1 Sao Paulo Hospital Israelita Albert Einstein Wallace Chamom A Siqueira 1 São Paulo Hospital Nove de Julho Maria Aparecida Mesa Munarin 3 São Paulo UNIFESP - Hospital São Paulo/HKIDNEY Denise de Freitas 317 Sorocaba Hospital Oftalmológico de Sorocaba Nicolas Cesario Pereira 1696 Name of the centre City state Total Bahia (2) Hospital Geral do Estado Salvador BA 1 Hospital Universitário Professor Edgard Santos Salvador BA 1 Mato Grosso (1) HPS Municipal Cuiaba MT 1 Minas Gerais (1) Hospital João XXIII Belo Horizonte MG 1 Paraná (2) Hospital Universitário Regional do Norte do Paraná Londrina PR 2 Rio Grande do Sul (20) Hospital Pronto Socorro Canoas RS 1 Hospital Pronto Socorro Porto Alegre RS 19 Santa Catarina (2) Hospital Regional Alto Vale Rio do Sul SC 1 Hospital Univ, Polydoro Ernani de São Thiago Florianópolis SC 1 89

The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2014, name of person responsible for the team and record of the results ABTO performed 2014 City Name of centre RBT - Evolution person responsible Bahia (54) Salvador Hospital São Rafael Marco Aurélio Salvino de Araújo 4 27 31 Salvador Hospital Univ, Prof, Edgard Santos Marco Aurélio Salvino de Araújo 2 21 23 Ceará (62) CE Fortaleza Hospital Monte Klinikum Edilson Diogenes Pinheiro Júnior 0 7 7 Fortaleza Hospital Univ, Walter Cantídio UFC Fernando Barroso Duarte 4 48 52 Fortaleza Unimed de Fortaleza Diana Jorge Pires 0 3 3 Distrito Federal (56) DF Brasília Hospital Brasília Alexandre Vinaud Hirayama 0 9 9 Brasília Hospital Brasília Fernando Sergio Blumm Ferreira 0 8 8 Brasília Hospital Brasília Jorge Vaz Pinto Neto 0 6 6 Brasília Instituto de Cardiologia do DF Gustavo Bettarello 0 33 33 Espírito Santo (34) ES Vitria Hospital Santa Rita de Cassia Edgar de Barros Nascimento 0 34 34 Minas Gerais (113) MG Belo Horizonte Núcleo de Hematologia e Transpl, Medula Óssea Wellington Morais de Azevedo 12 23 35 Belo Horizonte Santa Casa de Misericórdia Wellington Morais de Azevedo 18 25 43 Juiz de Fora Hospital Monte Sinai Abrahão Elias Hallack Neto 0 11 11 Juiz de Fora Hospital Univ, UFJF - Juiz de Fora Angelo Atalla 6 18 24 Pernambuco (214) PE Recife Hospital Memorial São José Patricia Markman 2 6 8 Recife IMIP - Instituto de Medicina Integral Prof, Fernando Figueira Mariana Coutinho D M Cahu 14 29 43 Recife Real Hosp, Português Benef, Luis Fábio Barbosa Botelho 65 98 163 Paraná (198) PR Curitiba Hospital de Clínicas Universidade Federal do Paraná Mariester Malvezzi 75 4 79 Curitiba Hospital Erasto Gaertner Johnny F, C, Camargo 5 17 22 Curitiba Hospital N, Sra, das Graças Ricardo Pasquini 47 4 51 Curitiba Hospital Pequeno Príncipe 8 2 10 Foz do Iguaçu União Oeste Paranaense de Est, e Combate Cancer Ademar Dantas da Cunha Júnior 0 19 19 Londrina Hospital Univ, de Londrina Leticia Navarro Gordan Ferreira Martins 1 16 17 Rio de Janeiro (185) RJ Niterói Hospital de Clínicas Niterói Ricardo de Sá Bigni 11 51 62 Rio de janeiro Hemorio - RJ Sergio de Souza Oliveira 0 7 7 Rio de Janeiro Hospital Unimed Rio Angelo Maiolino 0 20 20 Rio de Janeiro Hospital Univ, Clementino Fraga Filho Angelo Maiolino 0 8 8 Rio de Janeiro Hospital Univ, Pedro Ernesto Cristiana Souza 0 16 16 Rio de Janeiro Inst, Nac, de Câncer/Fund, Ary Frauzino Luis Fernando da Silva Bouzas 30 42 72 Rio Grande do Sul (86) RS Porto Alegre Hospital Clínicas Porto Alegre Lauro José Gregianin 7 6 13 Porto Alegre Hospital Clínicas Porto Alegre Lucia Mariano da Rocha Silla 41 32 73 Santa Catarina (87) SC Florianópolis Cepon de Santa Catarina Marco Antonio Silva Rotolo 0 87 87 São Paulo (924) SP Barretos Fundação Pio XII - Hospital de Câncer de Barretos Eduardo José de Alencar Paton 25 47 72 Campinas UNICAMP - Univ, Estadual de Campinas Cármino Antonio de Souza 22 18 40 Jaú Hospital Amaral Carvalho Vergílio Antonio R,Colturato 116 83 199 São Paulo Grupo de Apoio ao Adolescente e a Criança com Câncer - GRAACC Victor Gottardello Zecchin. Valéria Cortez Ginani 4 6 10 BA Allogeneic Autologous Total 90

The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2014, name of person responsible for the team and record of the results ABTO City Name of centre RBT - Evolution person responsible performed 2014 Allogeneic Autologous São Paulo Hospital Alemão Oswaldo Cruz Ana Rita Araujo 1 1 2 São Paulo Hospital Alemão Oswaldo Cruz Celso Mitsushi Massumoto 2 1 3 São Paulo Hospital Alemão Oswaldo Cruz Fábio Rodrigues Kerbauy 2 7 9 São Paulo Hospital Alemão Oswaldo Cruz Jacques Tabacof 0 3 3 São Paulo Hospital Alemão Oswaldo Cruz José Salvador R, de Oliveira 1 0 1 São Paulo Hospital Alemão Oswaldo Cruz Mariana de Mattos Nascimento 2 0 2 São Paulo Hospital Alemão Oswaldo Cruz Roberto Luiz Silva 3 0 3 São Paulo Hospital Clínicas FMUSP Maria Cristina Martins de Almeida Macedo 29 89 118 São Paulo Hospital do Câncer - A C Camargo Leila Maria Magalhães Pessoa de Melo 35 61 96 São Paulo Hospital Inglês Ltda Rosaura Saboya 0 69 69 São Paulo Hospital Israelita Albert Einstein Nelson Hamershlak. Ana Fernanda Yamazaki Centrone 35 17 52 São Paulo Hospital Santa Marcelina José Salvador R, de Oliveira 33 34 67 São Paulo Hospital São Camilo - Pompéia Frederico Luiz Dulley 4 8 12 São Paulo Hospital São Camilo - Pompéia Roberto Luiz da Silva 1 1 2 São Paulo IBCC - Instituto eiro do Controle do Câncer Roberto Luiz da Silva 42 23 65 São Paulo Santa Casa de Misericordia José Carlos Barros 9 56 65 São Paulo UNIFESP - Hospital São Paulo/HKIDNEY José Salvador R, de Oliveira 20 14 34 Total 91

The number of transplants performed per team, city and state, including: total number of registrations in the system, patients in follow-up, transplants performed in 2013, name of person responsible for the team and record of the results ABTO List of bone transplants performed in 2013 informed by the banks and list of transplant centres linked to each bank Rio de Janeiro (811) BANCO DE TECIDOS MÚSCULO ESQUELÉTICOS INTO - coordenador: Rafael Augusto Dantas Prinz 811 e-mail:banco_tecidos@into,saude,gov.br - (21) 2134-5264 Consultório Odontológico Brasília DF 2 Hospital Santa Lúcia Brasília DF 15 Hospital Meridional Cariacica ES 10 Hospital Evangélico de Vila Velha Vila Velha ES 42 Hospital Ortopédico de Goiânia Goiânia GO 11 Consultório Odontológico Belo Horizonte MG 3 Hospital Universitário São José Belo Horizonte MG 5 Hospital de Clínicas da Universidade Federal de Uberlandia Uberlândia MG 42 Hospital Unimed de Campo Grande Campo Grande MS 6 Hospital São Lucas FAG Cascavel PR 29 Consultório Odontológico Curitiba PR 45 Hospital Infantil Pequeno Príncipe Curitiba PR 53 Hospital Marcelino Champagnat Curitiba PR 8 Hospital Novo Mundo Curitiba PR 5 Hospital Santa Casa de Misericórdia de Curitiba Curitiba PR 2 Hospital Vita Batel Curitiba PR 6 Hospital XV Curitiba PR 33 Hospital da Cruz Vermelha Curitiba PR 8 Hospital da Providência Curitiba PR 31 Hospital Evangélico de Curitiba Curitiba PR 2 Instituto Kopp Curitiba PR 3 Hospital Universitário Cajuru Curitiba PR 6 Hospital do Trabalhador Curitiba PR 4 Hospital Estadual de Londrina Londrina PR 5 Hospital Evangélico de Londrina Londrina PR 13 Santa Casa de Londrina Londrina PR 7 Hospital Universitário da Regional do Norte do Paraná Londrina PR 7 Hospital Santa Casa de Misericórdia de Maringá Maringá PR 54 Hospital Estadual Dona Lindu Paraíba do Sul RJ 5 Casa de Saúde Santa Lúcia Rio de Janeiro RJ 1 Casa de Saúde São José Rio de Janeiro RJ 1 Consultório Odontológico Rio de Janeiro RJ 31 Hospital Badim Rio de Janeiro RJ 1 Hospital Copa D Or Rio de Janeiro RJ 38 Hospital Espanhol Rio de Janeiro RJ 1 Hospital Estadual da Criança Rio de Janeiro RJ 34 Hospital Quinta D Or Rio de Janeiro RJ 1 Instituto de Odontologia da Puc Rio de Janeiro RJ 2 Instituto Nacional de Traumatologia e Ortopedia INTO Rio de Janeiro RJ 93 Consultório Odontológico Natal RN 3 Hospital São Vicente de Paulo de Passo Fundo Passo Fundo RS 2 Hospital Santo Antonio Blumenau SC 8 Hospital da Caridade Florianópolis SC 44 Hospital Governador Celso Ramos Florianópolis SC 33 Hospital Infantil Joana de Gusmão Florianópolis SC 5 Hospital Infantil de Joinville Joinville SC 7 Consultório Odontológico Joinville SC 4 Centro Hospitalar Unimed Joinville SC 2 Hospital Sírio Libanês São Paulo SP 3 Hospital São Paulo São Paulo SP 1 City Total 92

Pernambuco (5) Banco Multitecidos IMIP / - coordenador: Cláudio Marques e-mail:bmt@imip,org.br- (81) 2122-4196 Instituto de Medicina Integral Professor Fernando Figueira Recife PE 5 Rio Grande do Sul (726) Associação Hospitalar Beneficente São Vicente de Paulo - coordenador: Francisco José dos Santos Neto 726 e-mail: btecidos@hsvp,com.br - (54) 3316-4017 Associação Hospitalar Beneficente São Vicente de Paulo Passo Fundo RS 46 Associação Hospitalar Beneficente São Vicente de Paulo Cruz Alta RS 04 Associação Hospitalar de Proteção à Infância Dr, Raul Carneiro Curitiba PR 01 Hospital da City de Passo Fundo Passo Fundo RS 70 Hospital Dr, Bartholomeu Tacchini Bento Gonçalves RS 02 Pio Sodalício Damas de Caridade de Caxias do Sul Caxias do Sul RS 29 São Paulo (20,139) UNIOSS LTDA - coordenador: Karla Bachega 15,530 e-mail: unioss@unioss,com.br - (14) 3454-0444 Hospital Ortopedico Goiania GO 34 Hospital São Lucas Cascavel PR 3 Hospital Clinicas da UFPR Curitiba PR 2 Hospital da XV Curitiba PR 2 Hospital Evangelico Curitiba PR 7 HPP - Hosp Pequeno Principe Curitiba PR 189 Hospital Envagelico Londrina PR 5 Santa Casa de Londrina Londrina PR 3 Centro Medico Campinas Campinas SP 5 HC - Unicamp Campinas SP 10 ABHU Hospital Universitario-UNIMAR Marília SP 3 Santa Casa de Marilia Marília SP 18 Banco de Tecidosdo Hospital Das Clínicas - FMUSP - Alberto Tesconi Croci 1,931 e-mail: banco,tecidos@usp.br - (11) 3083-4029 Centro Médico Campinas Campinas SP 48 AACD São Paulo SP 1 H Sírio Libanês São Paulo SP 12 HAOC São Paulo SP 13 Hcor São Paulo SP 37 HIAE São Paulo SP 28 Hosp 9 De Julho São Paulo SP 24 Hospital Santa Marcelina São Paulo SP 2 Hospital Vera Cruz São Paulo SP 7 Instituto De Ortopedia E Traumatologia Hcfmusp São Paulo SP 171 Samaritano São Paulo SP 3 Unimed Sorocaba Sorocaba SP 6 Banco de Tecidos Músculo-Esqueléticos da Santa Casa de Misericórdia de São Paulo 2,678 coordenador: Emerson Kiyoshi Honda e-mail: banco,tecidos@santacasasp,org.br- (11) 2176-1600 Monte Tabor Italo eiro São Rafael Salvador BA 38 Ortopédico De Goiania Goiania GO 1 Universitário São Jose Belo Horizonte MG 10 Villa da Serra Nova Lima MG 7 Evangélico de Curitiba Curitiba PR 2 Santa Casa de Maringá Maringá PR 6 Vera Cruz Campinas SP 2 Base de São José do Rio Preto São José do Rio Preto SP 10 AACD São Paulo SP 2 AC Camargo São Paulo SP 16 Albert Einstein São Paulo SP 4 Alemão Oswaldo Cruz São Paulo SP 36 Hospital São Luiz São Paulo SP 1 Nove De Julho São Paulo SP 5 Santa Casa de São Paulo São Paulo SP 73 Sírio Libanes São Paulo SP 5 City Total 5 93

Regions State City Laboratory Responsible North (3) AM Manaus Lab, de HLA da Fund, Hosp, de Hematologia e Hemoterapia William Sérgio do Sacramento do Amazonas PA Belém Lab de Imunogenética da Fundação Centro de Hemoterapia e Kennie Kelly dos Santos Amazonas Hematologia do Pará RO Porto Velho NATIVIDA - Núcleo de Atend, em Triagem Neonatal Georgia Daniela Marcusso Marques Northeast (10) BA Salvador Lab, de Imunogenética da Univ, Federal da Bahia Eliane Pereira Menezes BA Salvador Lab, e Imunogenética e Transplantes Grupo de Apoio A Tâmara Peixinho Criança Com Cancer - Bahia CE Fortaleza Lab, de Histocompatibilidade do Centro de Pesquisas em Sílvia Fernandes Doenças Hepato Renais do Ceará CE Fortaleza Lab de Histocompatibilidade do Hosp Geral de Fortaleza Valéria Pombo MA São Luís LEGH Hosp, Univ, Federal do Maranhão Emygdia R R B P L Mesquita PE Recife HEMOPE - Fund de Hematologia e Hemoterapia de PE Isa Maria Teixeira Leão PE Recife HLA DIAGNOSTICO LTDA Glauco Henrique Willcox PI Teresina LIB - Fundação Universidade Federal do Piauí Semiramis Jamil H do Monte RN Natal HLAVIDA - Serviços de Hemoterapia LTDA Renata Gomes Alves RN Natal Lab de Histocompatibilidade do Hemocentro do RN Dalton Andrea L A da Cunha Fernandes Barbosa Cunha Southeast (22) ES Vitória LIG Instituto de Imunogenética S/S LTDA Márcia Biccas MG Belo Horizonte Imunolab Imunologia de Transplantes Ltda Evaldo Nascimento MG Belo Horizonte Simile - Instituto de Imunologia Aplicada Ltda Carla Regina S C da Ronda MG Poços de Caldas Imunogen - Probio Diagnósticos Ltda Jordana Braga MG Uberlandia Laboratório de Imunologia e Transplantes Fernando Vinhal RJ Rio de Janeiro JRM Investigações Imunológicas LTDA Maria Elisa Hue Moraes RJ Rio de Janeiro Lab, de HLA - Inst Estadual de Hematologia - HEMORIO Shirley Lopes de Castilho RJ Rio de Janeiro Laboratório de HLA - Universidade do Estado do RJ Luis Cristovão M Sobrino Porto SP Barretos Lab, de Ánalises Clínicas/Patalogia Clínica - Fund Pio XII Rafael Formenton Cita SP Bauru Laboratório de HLA - Instituto Lauro de Souza Lima Elaine Valim Camarinha Marcos SP Bauru Lab de Imunogenética - Hosp de Reabilitação de Anomalias Elza Araújo Torres Craniofaciais - USP SP Campinas Lab, de Imunogenética e Transplantes - UNICAMP Maria Helena Stangler Kraemer SP Campinas Lab, de HLA - Fund de Desenvolvimento da UNICAMP Silvia Barbosa Dutra Marques SP Jaú Lab, de Histocompatibilidade - Fundação Dr, Amaral Carvalho Marcia Romero Martinez SP Marilia LIM-Laboratório de Imunologia de Marilia ltda Marcelo Ortega Ruiz SP Ribeirão Preto Lab, de HLA - Fundação Hemocentro de Ribeirão Preto Neifi Hassan Saloum Deghaide SP São J, do Rio Preto Instituto de Urologia e Nefrologia Mário Abbud Filho SP São J, do Rio Preto Lab, de Imunogenética Molecular -Fund, Fac, Reg, Medicina Luiz Carlos de Mattos SP São Paulo Lab, de HLA - Irmandade Santa Casa de Misericórdia Carmen Silvia Vieitas Vergueiro SP São Paulo Lab, de Imunogenética -Assoc, Fundo de Incentivo à Pesquisa Maria Gerbase de Lima SP São Paulo Lab, de Imunologia / HLA - FUNDACAO ZERBINI Jorge Kalil SP São Paulo Lab, de Técnicas Especiais - Hospital Albert Einstein Margareth Torres South (10) PR Curitiba Laboratório de Imunogenética - Hospital de Clínicas da Universidade Monica Evelise Silveira Federal do Paraná PR Curitiba Laboratório de Imunogenética -Associação Paranaense de Cristina Q C von Glehn Cultura - APC PR Curitiba LIGH - FUNDAÇÃO DA UNIVERSIDADE FEDERAL DO PARANÁ Maria da Graça Bicalho PR Londrina Lab, de Histocompatibilidade - Universidade Estadual de Marlene da Silva Bardi Londrina - HEMOCENTRO REGIONAL DE LONDRINA PR Maringá Histogene - Laboratório de Histocompatibilidade e Genética L Erika Noda Noguti PR Maringá LIG - Univ, Estadual de Maringá Ana Maria Sell RS Porto Alegre Laboratório de Imunologia de Transplantes - Irmandade da Jorge Neumann Santa Casa de Misericórdia RS Porto Alegre Qualimune Laboratório de Imunogénetica LTDA Jorge Neumann RS Porto Alegre Serviço de Imunologia - Hospital de Clinicas de Porto Alegre Luiz Fernando Job Jobim SC Florianópolis Lab, de Imunogenética - Fund Apoio ao HEMOSC/CEPON Leila Chirliane Dalmolin Pereira Midwest (4) DF Brasília Laboratório de Histocompatibilidade - Fundação Hemocentro Hugo Mundim GO Aparecida de HLAGYN - Lab, de Imunologia de Transplantes de Goiás Ltda Fernando Vinhal Goiânia MS Campo Grande Biomolecular - Lab, Biologia Molecular e Histocompatibi Zuleica Aparecida C Ascenço MT Cuiabá HGU - Associação de proteção a maternidade e a infância Flavia Galindo Silvestre 94

Sistema Nacional de Transplantes (SNT) Heder Murari Borba Phone: (61) 3315-9212 Central Nacional de Transplantes (CNT) Evelyn Heinzen Phone(61) 3345-8465 / 3363-1314 List of National and State Coordination Transplant e-mail: snt@saude.gov.br e-mail: cnncdo@saude.gov.br Acre Regiane Clélia Ferrari Phone/Fax: (68) 3227-6399 / (68) 9985-2061 E-mail: cncdoacre@ac.gov.br e cncdoacre@gmail.com Alagoas Kelly Karina de Araújo Brandão Phone/Fax: (82) 3376-8186 / (82) 3315-7440 E-mail: doevida@saúde.al.gov.br Goiás Dr. Luciano Leão Bernardino da Costa Phone/Fax: (62) 3201 6270 / 3201 6721 / 3201 6722 / 9614 7990 E-mail: centraltransplantes.go@saude.gov.br Maranhão Dra. Silvana dos Santos Oliveira Phone: (98) 2109-1276 / 2109-1212 E-mail: ctx@huufma.br Mato Grosso Fabiana Regina de Souza Molina Phone: (65) 3324-0747 / 3623-9004 / 3623-9188 Fax: (65) 3623-9004 E-mail: contran@ses.mt.gov.br Amapá Eduardo Monteiro Cardoso Phone: (96) 3212-6281/Fax: (96) 3212-6282 E-mail: cncdo@saúde.ap.gov.br Amazonas Dra. Leny Nascimento da Motta Passos Phone/ Fax: (92) 3664-2616 / (92) 8802-6801 E-mail: cncdo.am@saúde.gov.br Bahia Dr. Eraldo Salustiano de Moura Email: sesab.transplante@saude.ba.gov.br Central de Notificação Captação e Doação de òrgãos - CNCDO América Carolina Melo Sodré Phone: (71) 3356-6776/ 3117-0130/9956-0527 E-mail: transplantes.ba@gmail.com OPO-HGE Dra Ana Paula Baptista Phone:(71)31175838 / (71)33564687 E-mail: gadhgebahia@hotmail.com OPO-HGRS Dra Barbara Kraychet Phone:(71)33874572 / (71)33873424 (FAX) OPO HOSPITAL GERAL ERNESTO SIMÕES FILHO Dra Ana Paula Baptista/ Dra Barbara Phone: (71)31171730 / (71)31171785 OPO EXTREMO The South Humberto Martins Phone: (73)31122867 OPO-FEIRA DE SANTANA André Guimarães Phone:(75)36023300 / (75)36023333 OPO The South (Ilheus/ITABUNA) Dr José Mesquita Phone:(73)32141600 / (73)21025107 OPO-VITÓRIA DA CONQUISTA Dra Edney Matos Phone:(77)34274584 Ceará Dra. Eliana Régia Barbosa de Almeida Phone: (85) 3252-1886 / 3101-5238 E-mail: cncdo@saúde.ce.gov.br Distrito Federal Dra. Daniela Ferreira Salomão Phone: (61) 3315-1664 / (61) 3315-1755 E-mail: centraldetransplantedf@gmail.com Espírito Santo Rosemery Gueis Nunes Erlacher Phone: (27) 3235-1028/Fax: (27) 3137-2411 E-mail: cncdo@saúde.es.gov.br Mato Grosso do Sul Claire Carmem Miozzo Phone: (67) 3312-1456 / 3321-8877 / 3312-1400 E-mail: cet@saúde.ms.gov.br Minas Gerais Dr. Charles Simão Filho Phone: (31) 3219-9200 / 0800 2837 183 E-mail: mgtransplantes@saúde.mg.gov.br CNCDO Metropolitano - Belo Horizonte Omar Lopes Cançado Júnior Phone: (31) 3219 9200 / (31) 3219 9211 E-mail: mgtransplantes@saúde.mg.gov.br CNCDO Leste - Governador Valadares Dr. Célio Ferreira Magalhães Phone: (33) 3271 1909 / 9954-1569 (plantão) E-mail: mgtx.gva@saúde.mg.gov.br CNCDO Oeste - Uberlândia Dr. Thonson Marques Palma Phone/Fax: (34) 3218-2323/ 3212-1780 E-mail: mgtx@hc.ufu.br CNCDO Sul - Pouso Alegre Pablo Giardelli M. Mesquita Phone/Fax: (35) 3422-0334 / 2345 R. 277 E-mail: cncdosul@yahoo.com.br CNCDO Norte/The Northeast - Montes Claros Dra. Sonia Rodrigues Cruz Phone: (38) 3229-2097/Fax: (38) 3213-3676 E-mail: cncdonone@ig.com.br CNCDO Zona da Mata - Juiz de Fora Dr. Joseph Fredric Whitaker Phone: (32) 3229-2392 E-mail: mgtxjf@hotmail.com Pará Dra. Ana Cristina Simões Beltrão Phone/Fax: (91) 4006-4284 E-mail: cncdo.transplantes@gmail.com Paraíba Dra. Gyanna Lys de Melo Moreira Montenegro Phone/Fax: (83) 3244-6192 / 3225-6409 / 8845-3516 E-mail: transplante@gmail.com Paraná Dra. Arlene Terezinha Cagol Garcia Badoch Phone/Fax: (41) 3304-1900/ 1909 E-mail: sesatran@sesa.pr.gov.br COPOTT - Cascavel Rosimeri Lima Tome Phone: (45) 3321-5505 / 5506 E-mail: crtcascavel@hotmail.com COPOTT - Londrina Ogle Beatriz Bacchi de Souza Phone: (43) 3379-6078/Fax 3344-5339 E-mail: transplante.17rs@sesa.pr.gov.br COPOTT - Maringá Gislaine Fusco Duarte 95

List of National and State Coordination Transplant 96 Phone/Fax: (44) 3227-3274 / 3249 E-mail: cncomaringa@sesa.pr.gov.br Pernambuco Noemy Gomes Phone: (81) ) 3181-6207/ 6206/ 6209 E-mail: transplantespe@saúde.gov.br Instituto de Medicina Integral de Pernambuco - IMIP Petrus Moura de Andrade Lima Phone:(81) 2122-4110 / 8652-9134 Real Hospital Português De Beneficência Em Pernambuco André Bezerra Pereira do Rêgo Phone:(81) 3416-1878 / 9976-0147 Casa de Saúde Santa Efigênia Albiégio Carlos Tavares Phone:(81) 9927-6594 Hospital Dom Malam Tatiana Cerqueira da Cunha Cavalcanti Phone:(87) 3202-7000 / 8835-2136 Piauí Dra. Maria de Lourdes de Freitas Veras Phone/Fax: (86) 3221-7553 /3216-3553 E-mail: cncdopi@saúde.pi.gov.br Rio de Janeiro Rodrigo Alves Sarlo Phone: (21) 2333-7535 / 7543 / 7550 / 7544 / 7545 / 7548 / 7552 E-mail: transplantes@saúde.rj.gov.br Rio Grande do Norte Artenise Revoredo Phone: (84) 3232-7620 / 8839-8452 E-mail: cncdo@rn.gov.br Rio Grande do Sul Dra. Rosana Reis Nothen Phone/Fax: (51) 3353-3030 E-mail: centraldetransplantes@saúde.rs.gov.br OPO I ISCMPA Dra. Fernanda Bonow Phone/Fax: (51) 3213.7320 / (51) 3213.7325 E-mail: febonow@gmail.com OPO II PUC Dr. Leonardo Kroth Phone/Fax: (51) 3320-3261 E-mail: opo2@pucrs.br OPO III POMPÉIA Dra. Margarete Ronsani Phone/Fax: (54) 3220.8023 E-mail: opo3@pompeia.org.br OPO IV SÃO VICENTE PAULO Dr. Cassiano Crusius Phone/Fax: (54) 3316.4000 / (54) 3316.8374 E-mail: opo4@hsvp.com.br OPO V STA CASA RIO GRANDE Dr. Newton Primo Phone/Fax: (53) 3233.7100 / (53) 3233.7188 E-mail: opo@santacasarg.com.br OPO VI BRUNO BORN Dra. Graziela Denardim Phone/Fax: (51) 3714.7500 E-mail: opo6@hbb.com.br OPO VII INSTITUTO CARDIOLOGIA Dr. Leonardo Dias E-mail: ldcezar@hotmail.com Rondônia Edcléia Gonçalves da Silva Phone: (69) 3216-5738 / 3216-5747 E-mail: gcetro@gmail.com / alessandro.prudente01@gmail.com Roraima Dr. Douglas Henrique Teixeira Phone: 95-2121-0560/2121-0620 E-mail: direcaogeral.hgr@gmail.com / marisa.pedrosi@gmail.com Santa Catarina Dr. Joel de Andrade Phone: (48) 3212-1612 / 3212-1613 / 0800-6437474 E-mail: getra@saúde.sc.gov.br / cncdoinfo@saúde.sc.gov.br / Sergipe Benito Oliveira Fernandez Phone: (79) 3259-2899 / 3216-2870 E-mail: transplante@saúde.se.gov.br São Paulo - CNCDO I Dr. Agenor Spallini Ferraz Phone: (11) 3064-1649 / 3088-5094 E-mail: ctrans@saúde.sp.gov.br CNCDO II - Interior Dr. Agenor Spallini Ferraz Phone: 16) 3607-4262/4261/4263 E-mail: cncdo2@fmrp.usp.br OPO / HC Dr. Leonardo Borges de Barros e Silva Phone/Fax: (11) 2661-8004 / 2661-6543 E-mail: spot.ichc@hc.fm.usp.br OPO / Santa Casa de São Paulo Dr. Reginaldo Carlos Boni Phone: (11) 2176-7185/7391/5185 E-mail: opo@santacasasp.org.br / caporgao@santacasasp.org.br OPO / Dante Pazzanese Dr. Antonio Flavio de Almeida Sanchez Phone: (11) 5085-6015/Fax: (11) 5571-8601 E-mail: spot@dantepazzanese.org.br OPO / EPM Dr. Diogo Medeiros Phone/Fax: (11) 5572-8749 / 5081-2183 E-mail: opoepm@hrim.com.br OPO / Campinas Dr. Luis Antonio Costa Sardinha Phone: (19) 3521-8000/ 3521-7259 E-mail: captacao@hc.unicamp.br OPO / São José do Rio Preto Dr. João Fernando Picollo de Oliveira Phone: (17) 3227-7030 Fax: (17) 3227-7033 E-mail: captacaodeorgaos@hospitaldebase.com.br OPO / Botucatu Dr. Reginaldo Carlos Boni Phone: (14) 3811-6386 / 3813-3344 E-mail: spot.botucatu@fmb.unesp.br OPO / Sorocaba Dr. Frederico Augusto Pinho Rocha Phone: (15) 3232-4049 / 3332-9100 R: 9283 E-mail: chs-opo-sorocaba@saúde.sp.gov.br OPO / Ribeirão Preto Dr. Jeová Nina Rocha Phone: (16) 3602-2777/ 3633-2189 E-mail: oporibeirao@yahoo.com.br OPO / Marília Phone: (14) 3402-1748 / 1744 R: 1005 E-mail: spotmarilia@famema.br Tocantins Donilda Moreira Rodrigues Phone: (63) 8107-3855 / 3218-3230 E-mail: transplanteto@yahoo.com.br

Schedule sending data 2015 Visit : www.abto.org.br/rbt and update periodically their data according to a schedule for data collection ian Transplant Registry in 2015 Limit Date PERIOD 10/02/2015 January 10/03/2015 February 08/04/2015 March 28/04/2015 Publication do RBT 1st quarter 2015 08/05/2015 April 10/06/2015 May 08/07/2015 June 28/07/2015 Publication do RBT 1st half of 2015 10/08/2015 July 10/09/2015 August 08/10/2015 September 28/10/2015 Publication do RBT 3rd Quarter 2015 10/11/2015 October 10/12/2015 November 08/01/2016 December 09/02/2016 Publication do RBT Annual 2015

Associação eira de Transplante de Órgãos Av, Paulista. 2001-17º andar - cj, 1704 / 1707 São Paulo - SP CEP 01311-030 Phone 11 3283-1753 / 3262-3353 E-mail: abto@abto,org.br www,abto,org.br