Schedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK

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1 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK Laboratory locations: Frimley Park Hospital Portsmouth Road Frimley Camberley GU16 7UJ Contact: Elaine Inglis Tel: +44 (0) / Elaine.Inglis1@nhs.net Website: below s covered by the organisation and their relevant activities details Activity code Address Frimley Park Hospital Portsmouth Road Frimley Camberley GU16 7UJ Local contact Elaine Inglis Chemistry St Peter s Hospital Guildford Road Lyne Chertsey KT16 0PZ As above Chemistry Royal Surrey County Hospital Guildford GU2 7XX As above Chemistry, SAS Service for Peptide Hormones SAS Trace Elements Centre 15 Frederick Sanger Road Guildford Surrey GU2 7YD As above SAS Service for Trace Elements Bowel Cancer Screening Centre Surrey Research Park 20 Priestley Road Guildford Surrey GU2 7YS As above Bowel screening BCSC Assessment Manager: GD1 Page 1 of 17

2 DETAIL OF ACCREDITATION clinical diagnosis Quantification of: Siemens Advia 2400 / 1800 Generic SOPs: BIO-SPS-SOP-003 BIO--SOP-001 BIO-A-SOP-13 BIO--SOP-001 BIO--SOP-003 BIO-A-SOP-54 BIO--SOP-002 Instruments: Advia serial no CA Advia serial no CA Advia serial no CA Advia serial no CA Advia serial no CA Advia serial no CA Advia serial no CA Albumin BCG dye binding BIO-SPS-ED-00102,, Alkaline Phosphatase Modified IFCC BIO-SPS-ED-00104,, Assessment Manager: GD1 Page 2 of 17

3 clinical diagnosis Quantification of: Siemens Advia 2400 / 1800 Alpha 1 antitrypsin PEG enhanced BIO-SPS-ED ALT Modified IFCC BIO-SPS-ED-00104,, Lithium heparin, EDTA Ammonia Enzymatic BIO-SPS-ED Serum, urine, lithium heparin Amylase Ethylidene blocked-pnpg7 BIO-SPS-ED-00107,, Apo A1 PEG enhanced BIO-SPS-ED Apo B PEG enhanced BIO-SPS-ED AST Modified IFCC BIO-SPS-ED-00110,, Bicarbonate Enzymatic BIO-SPS-ED-00191,, EDTA Bile acids Enzymatic BIO-SPS-ED-00167,, Bilirubin (Direct) Vanadate oxidation BIO-SPS-ED-00111,, Assessment Manager: GD1 Page 3 of 17

4 clinical diagnosis Quantification of: Siemens Advia 2400 / 1800 Bilirubin (Total) Vanadate oxidation BIO-SPS-ED-00112,, Serum, urine, lithium heparin Calcium Arsenazo III BIO-SPS-ED-00291,, Serum Carbamazepine Enzyme multiplied immunoassay technique (EMIT) BIO-SPS-ED Serum, urine, sweat ( only), lithium heparin Chloride Indirect ISE BIO-SPS-ED-00116,, Cholesterol Enzymatic BIO-SPS-ED BIO-SPS-ED-025,, C-Reactive Protein Latex enhanced BIO-SPS-ED-00122,, Creatine Kinase NAC activated IFCC BIO-SPS-ED-00120,, Serum,urine, lithium heparin, EDTA Creatinine Enzymatic BIO-SPS-ED-00121,, Digoxin Latex enhanced BIO-SPS-ED Assessment Manager: GD1 Page 4 of 17

5 clinical diagnosis Quantification of: Siemens Advia 2400 / 1800, EDTA Ethanol Enzymatic BIO-SPS-ED-00166, Gamma Glutamyl Transferase Modified IFCC BIO-SPS-ED-00127,, Fluoride oxalate, urine, CSF, serum, lithium heparin, EDTA Glucose Hexokinase BIO-SPS-ED BIO-SPS-ED-00128,,, EDTA HDL Elimination / catalase BIO-SPS-ED-00119,,, EDTA hscrp Latex enhanced BIO-SPS-ED Iron Ferrozine BIO-SPS-ED-00130,, Fluoride oxalate, lithium heparin, EDTA Lactate Lactate oxidase, colourimetric BIO-SPS-ED LDH Enzymatic (pyruvate -> lactate) BIO-SPS-ED-00131,, Lipase Colourimetric rate BIO-SPS-ED Assessment Manager: GD1 Page 5 of 17

6 clinical diagnosis Quantification of: Siemens Advia 2400 / 1800, EDTA, sodium citrate Lipoprotein (a) Latex enhanced BIO--ED Serum, EDTA Lithium Spectrophotometric BSC ED 00154, Magnesium Xylidyl blue BIO-SPS-ED-00132,, Urine Microalbumin PEG enhanced BIO-SPS-ED-00133, Serum, fluoride oxalate, lithium heparin, EDTA, sodium citrate Paracetamol Enzymatic BIO-SPS-ED-00185,, Serum Phenytoin Enzyme multiplied immunoassay technique (EMIT) BIO-SPS-ED Serum, urine, lithium heparin Phosphate Phosphomolybdate/UV BIO-SPS-ED BIO-SPS-ED-00135,, Serum, urine, lithium heparin Potassium Indirect ISE BIO-SPS-ED-0012,, Serum Salicylate Enzymatic BIO-SPS-ED-00156,, Assessment Manager: GD1 Page 6 of 17

7 clinical diagnosis Quantification of: Siemens Advia 2400 / 1800 Serum, urine, lithium heparin Sodium Indirect ISE BIO-SPS-ED-00136,, Serum Theophylline Enzyme multiplied immunoassay technique (EMIT) BIO-SPS-ED Total Protein Biuret BIO-SPS-ED BIO-SPS-ED-00138,, Urine, CSF Total Protein (urine) Dye binding BIO-SPS-ED-00140,,, EDTA Transferrin PEG enhanced BIO-SPS-ED-00141,, Triglyceride Trinder BIO-SPS-ED-00142,, Serum, urine, lithium heparin Urea Urease with GLDH BIO-SPS-ED-00144,, Serum, urine, lithium heparin Uric acid Uricase / peroxidase BIO-SPS-ED-00145,,, EDTA AKI,, Assessment Manager: GD1 Page 7 of 17

8 clinical diagnosis Quantification of: Siemens Advia 2400 / 1800, EDTA egfr,, Globulin,, Adjusted calcium,, Cholesterol:HDL ratio,, Non-HDL cholesterol,, LDL cholesterol (calculated),, Iron saturation,, Urine 24h urine excretion (may be used for any urine analyte),, Urine Urine protein:creatinine ratio urine,, Assessment Manager: GD1 Page 8 of 17

9 clinical diagnosis Quantification of: Siemens Advia 2400 / 1800 Urine Urine albumin:creatinine ratio (microalbumin), Urine Creatinine clearance,, Urine Calcium:creatinine clearance ratio,, Quantification of: Advia Centaur XP BIO-SPS-SOP-012 BIO-SPS-SOP-017 BIO-A-SOP-9 BIO--SOP-004 Instruments: Centaur XP-1 serial no 8323 Centaur XP-2 serial no 7520 Centaur XP-3 serial no 4823 Centaur XP-1 serial no 9864 Serum 25 Hydroxy Vitamin D Competitive immunoassay BIO-SPS-ED Serum Alpha-fetoprotein Two site sandwich immunoassay BIO-SPS-ED EDTA BNP Two site sandwich immunoassay BIO-SPS-ED-00201,, Assessment Manager: GD1 Page 9 of 17

10 clinical diagnosis Quantification of: Advia Centaur XP Serum CA 125 Two site sandwich immunoassay BIO-SPS-ED Serum CA 15-3 Two step sandwich immunoassay BIO-SPS-ED Serum CA199 Two step sandwich immunoassay BIO-SPS-ED Serum Carbamazepine Competitive immunoassay BIO-SPS-ED Serum CEA Two-step sandwich immunoassay BIO-SPS-ED Serum Cortisol Competitive immunoassay BIO-SPS-ED Serum DHEAS Competitive immunoassay BIO-SPS-ED Serum Digoxin Competitive immunoassay BIO-SPS-ED-00208,,,,,,, EDTA Ferritin Two-site sandwich immunoassay BIO-SPS-ED-00210, Serum Folate Competitive immunoassay BIO-SPS-ED Serum FSH Two-site sandwich immunoassay BIO-SPS-ED-00212,, EDTA Gentamicin Competitive immunoassay BIO-SPS-ED-00215, Assessment Manager: GD1 Page 10 of 17

11 clinical diagnosis Quantification of: Advia Centaur XP Serum HCG (Non-Downs) (Non Tumour Marker) Two-site sandwich immunoassay BIO-SPS-ED-00216, EDTA Homocysteine Competitive immunoassay BIO-SPS-ED Serum LH Two-site sandwich immunoassay BIO-SPS-ED Serum Oestradiol Competitive immunoassay BIO-SPS-ED Serum Phenytoin Competitive immunoassay BIO-SPS-ED Serum Progesterone Competitive immunoassay BIO-SPS-ED Serum Prolactin Two-site sandwich immunoassay BIO-SPS-ED Serum PSA (Total) Two-site sandwich immunoassay BIO-SPS-ED EDTA PTH Two-site sandwich immunoassay BIO-SPS-ED Serum SHBG Sandwich immunoassay BIO-SPS-ED Serum T3 (Free) Competitive immunoassay BIO-SPS-ED Serum T4 (Free) Competitive immunoassay BIO-SPS-ED-00214,,,,,,,, Assessment Manager: GD1 Page 11 of 17

12 clinical diagnosis Quantification of: Advia Centaur XP Serum Testosterone Competitive immunoassay BIO-SPS-ED Serum Theophylline Competitive immunoassay BIO-SPS-ED Serum Troponin I Three site sandwich immunoassay BIO-SPS-ED Serum TSH Two-site sandwich immunoassay BIO-SPS-ED Serum Valproate Competitive immunoassay BIO-SPS-ED-00263,, EDTA Vancomycin Competitive immunoassay BIO-SPS-ED-00226,, EDTA Vitamin B12 Competitive immunoassay BIO-SPS-ED-00227, Serum Macroprolactin PEG precipitation followed by twosite sandwich immunoassay BIO-SPS-SOP-015, Serum Free androgen index BIO-/A-SOP-001 using Clinisys Serum Free testosterone BIO-/A-SOP-001 using Clinisys Serum Post-PEG prolactin BIO-/A-SOP-001 using Clinisys Lithium heparin whole blood Ammonia Solid phase dye binding on the Menarini Ammonia Checker II BIO-/-SOP-003,, Assessment Manager: GD1 Page 12 of 17

13 clinical diagnosis Faeces Calprotectin Accusay ELISA on Stratec Gemini, BIO--SOP-002 Sweat Chloride Titration on the Sherwood 926s chloride meter BIO--SOP-020 EDTA whole blood HbA1c Ion exchange HPLC on the Tosoh G8 BIO--SOP-054 Serum, Urine Osmolality Freezing point depression on the Advanced Instruments Micro- Osmometer BIO-SPS-SOP-014 Lithium heparin whole blood Troponin T Sandwich immunoassay on the Roche Cobas h232 BIO--SOP-005,, Urine Urinalysis of: Leukocytes Nitrites Urobilinogen Protein ph Blood Specific Gravity Ketones Bilirubin Glucose Siemens 10SG urinalysis strips with Cliniteck 50 BIO-SPS-SOP-016 CSF Xanthochromia Spectrophotometric using the Uvikon XL spectrophotometer BIO-SPS-SOP-021, Serum, Lithium Heparin Insulin Mercodia Iso-insulin Enzyme Linked Immunosorbent Assay (ELISA), PEP--SOP Assessment Manager: GD1 Page 13 of 17

14 clinical diagnosis Serum, Lithium Heparin Insulin Mercodia Insulin Enzyme Linked Immunosorbent Assay (ELISA), PEP--SOP Serum, Lithium Heparin C-Peptide Mercodia ELISA, PEP--SOP Serum, Lithium Heparin Proinsulin Mercodia ELISA, PEP--SOP Serum Growth Hormone IDS isys, chemiluminescence, PEP--SOP Serum Insulin like Growth factor - I IDS isys, chemiluminescence, PEP--SOP Serum Insulin like Growth factor - II In -house competitive radioimmunoassay (RIA), PEP--SOP Serum IGF-BP3 IDS isys, chemiluminescence, PEP--SOP Serum IgG Insulin Antibodies Biomerica Isletest ELISA, PEP--SOP Serum, urine Sulphonylurea Liquid chromatography tandem mass spectrometry, PEP--SOP Serum Gastrin MP Biomedicals RIA, PEP--SOP Serum β Hydroxybutyrate Spectrophotometric using the GENESYS 10 spectrophotometer, PEP--SOP Serum IGF-BP1 Medix Biochemica ELISA, PEP--SOP Serum IGF-BP2 Mediagnost ELISA, PEP--SOP Assessment Manager: GD1 Page 14 of 17

15 clinical diagnosis Serum Erythropoietin Siemens Immulite 2000, chemiluminescence, PEP--SOP Serum Thyroglobulin Siemens Immulite 2000, chemiluminescence, PEP--SOP Serum Thyroglobulin Antibodies Siemens Immulite 2000, chemiluminescence, PEP--SOP Whole Blood (EDTA) Immunosuppressants (Tacrolimus, Sirolimus, Ciclosporin) Liquid chromatography tandem mass spectrometry, PEP--SOP Inductively coupled mass spectrometry (ICP-MS) Thermo icap-q All trace element matrices Multi-elemental analysis of blood, serum and urine by ICP-MS TRACE--SOP-48 All trace element matrices Preparation of standards for icap ICP-MS TRACE--SOP-53 Serum,, water, dialysate Aluminium TRACE--SOP-20 Blood, serum,, urine, solid samples Arsenic TRACE--SOP-33, TRACE- -SOP-11 Blood, serum,, urine, solid samples Cadmium TRACE--SOP-14, TRACE- -SOP-11 Blood, serum,, urine, hip fluids/aspirates, solid samples Chromium TRACE--SOP-18, TRACE- -SOP-11 Assessment Manager: GD1 Page 15 of 17

16 clinical diagnosis Blood, serum,, urine, hip fluids/aspirates, solid samples Cobalt TRACE--SOP-18, TRACE- -SOP-11 Serum,, urine, solid samples Copper TRACE--SOP-16, TRACE- -SOP-11 Serum,, urine Gold TRACE--SOP-27 Urine, solid samples Iron TRACE--SOP-25, TRACE- -SOP-11 Blood, urine, solid samples Lead TRACE--SOP-14, TRACE- -SOP-11 Blood, Magnesium TRACE--SOP-24 Red cells - calculated Magnesium TRACE--SOP-24 Blood, serum,, urine Manganese TRACE--SOP-14 Blood, serum,, urine, solid samples Mercury TRACE--SOP-23, TRACE- -SOP-11 Blood, serum,, urine Molybdenum TRACE--SOP-21 Blood, serum,, urine Antimony, Bismuth, Nickel, Platinum, Vanadium TRACE--SOP-15 Serum,, urine Selenium TRACE--SOP-17 Blood, serum,, urine Silver TRACE--SOP-19 Blood, serum,, urine Thallium TRACE--SOP-22 Serum,, urine Zinc TRACE--SOP-16 Blood, serum,, urine, solid samples Semi-quantitative analysis of all elements from atomic numbers 3 to 85 TRACE--SOP-48, TRACE- -SOP-11 Assessment Manager: GD1 Page 16 of 17

17 clinical diagnosis Faeces Occult Blood Guaiac Hema Screen card BCSP--SOP-17 BCSC END Assessment Manager: GD1 Page 17 of 17

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