Molecular Targeted Therapy of Cancer

PRELIMINARY PROGRAM 9 th Latin American Medical Education Workshop on Molecular Targeted Therapy of Cancer Santiago, Chile November 4-5, 2011

9 th Latin American Medical Education Workshop on Molecular Targeted Therapy of Cancer Aim of the meeting The International Education Initiative on Molecular Targeted Therapy of Cancer (MTTC) was initiated in 2001 with the aim of developing content for high quality medical education for oncologists. Based on the presentations of the first International Workshop on MTTC in Paris in 2002, an educational core curriculum has been developed, directed by the members of the International Education Council. This 9 th Latin American Workshop on MTTC is an activity within the International Medical Educational Initiative on MTTC in Latin America, which began with the 1 st Latin American Workshop on MTTC in Bariloche, Argentina (2003) and was followed by further workshops in Cancun, Mexico (2004), Trancoso, Brazil (2005), Pucón, Chile (2006), Rio de Janeiro, Brazil (2007), Buenos Aires, Argentina (2008), Quito, Ecuador (2009) and Lima, Peru (2010). A distinguished group of Latin American oncology experts from different disciplines will be giving educational presentations on the basic mode of action and clinical application of various targeted therapies. Learning objectives The objectives of this workshop are: To understand the basics of signal transduction, angiogenesis and antibody-based therapy with regard to cancer therapy To understand the benefit of targeted therapy of cancer To relate the latest developments in the fields of signal transduction, angiogenesis, and antibody-based therapy with regard to targeted cancer therapy This workshop is designed to foster extensive discussion of the presented data. 1

Target audience Oncologists, radiation-oncologists, surgeons, pathologists. Accreditation The 9 th Latin American MTTC Workshop (Santiago, Chile - November 4-5, 2011) will be submitted for CME accreditation by European Society for Medical Oncology (ESMO). All Serono Symposia International Foundation programs are organized solely to promote the exchange and dissemination of scientific and medical information. No forms of promotional activities are permitted. All Serono Symposia International Foundation programs are made possible thanks to the unrestricted Educational grant received from: Centre d Esclerosi Multiple de Catalunya, ComtecMed, Congrex Sweden, Congrex Switzerland, Cryo-Save, Datanalysis, Esaote, European Society of Endocrinology, Fundación IVI, ISFP International Society for Fertility Preservation, ISMH International Society of Men s Health, K.I.T.E., Merck Serono, Ministry of Health of the State of Israel, University of Catania, Vall d'hebron University Hospital. 2

Scientific Organizer Carlos Vallejos Chairman of the Latin American Education Council Instituto Nacional de Enfermedades Neoplàsticas Lima, Peru Scientific Secretariat Serono Symposia International Foundation Salita di San Nicola da Tolentino, 1/b 00187 Rome, Italy Senior Project Manager: Francesca Pellegrino T +39-(0)6-420 413 511 F +39-(0)6-420 413 677 E-mail: info@seronosymposia.org Serono Symposia International Foundation is a Swiss Foundation with headquarters in 14, rue du Rhône, 1204 Geneva, Switzerland Organizing Secretariat Meridiano Congress International Via Mentana, 2/B 00185 Rome, Italy Senior Project Manager: Debora Urbinelli T +39 (0)6 88 595 232 F +39 (0)6 88595 234 E-mail: d.urbinelli@meridiano.it 3

Latin American Education Council José Luis Aguilar Ponce Instituto Nacional de Cancerología Mexico City, México Carlos Canela Clinica Santa Sofia Caracas, Venezuela Andrés Felipe Cardona Institute of Oncology Fundación Santa Fe de Bogotá Bogotá, Colombia Bernardo Garicochea Hospital São Lucas Porto Alegre, Brazil Jorge León Chong Oncosalud and Instituto Oncologico Miraflores Lima, Peru Hernán Lupera Hospital Metropolitano Quito, Ecuador Clarissa Mathias Núcleo de Oncologia da Bahia and Hospital Português Salvador de Bahia, Brasil Elizabeth Mickiewicz Instituto Angel H. Roffo Universidad de Buenos Aires Buenos Aires, Argentina José Miguel Reyes Clinica Las Condes Santiago, Chile 4

Rachel Riechelmann Instituto do Cancer do Estado de São Paulo Oncology Department São Paulo, Brazil Carlos Silva Hospital Britanico de Buenos Aires Buenos Aires, Argentina Carlos Vallejos Chairman of the Latin American Education Council Instituto Nacional de Enfermedades Neoplàsticas Lima, Peru 5

Scientific Program November 4-5, 2011 Friday - November 4, 2011 09.00 Registration Welcome and Introduction Chairmen: C. Vallejos, Peru - J.M. Reyes, Chile 10.00 Welcome Address J.M. Reyes, Chile 10.05 Introduction to the Medical Education Initiative on Molecular Targeted Therapy of Cancer C. Vallejos, Peru 10.15 Clinical implications of molecular targeted therapies of cancer: where are we today? C. Baldotto, Brazil Session I Chairmen: W.E. Berdel, Germany - C.Silva, Argentina 10.40 Targets in the neoplastic cell, focus in cell receptors and signal transductions: role of epigenetics B. Garicochea, Brazil 11.00 Targets of the cell enviroment: role of angiogenesis inhibition in cancer W.E. Berdel, Germany 11.20 Discussion 11.40 Coffee Break 12.00 Targeting the immune system: what s new C. Silva, Argentina 12.20 New concepts in old targets: focusing on mechanism of resistance H. Lupera, Ecuador 12.40 Discussion 13.00 Lunch Break Biological Targets in the treatment of cancer 6

Session II Chairmen: S. Siena, Italy - L. Contreras, Chile 14.00 Advances in molecular diagnosis L. Contreras, Chile 14.20 Clinical biomarkers in solid tumors S. Siena, Italy 14.40 Clinical biomarkers in hematologyc malignancies J. León Chong, Peru 15.00 Discussion The changing approach in treating cancer 15.30 End of the first day 7

Saturday - November 5, 2011 Session III Clinical Applications: from the lab to the clinic Chairmen: C. Vallejos, Peru - J.M. Reyes, Chile 09.00 Molecular Treatment of NET Speaker to be confirmed 09.20 Molecular Treatment of Colorectal Cancer R. Riechelmann, Brazil 09.40 Molecular Treatment of Lung Cancer C. Mathias, Brazil 10.00 Discussion 10.30 Coffee Break 11.00 Molecular Treatment of Head & Neck Cancer C. Canela, Venezuela 11.20 Molecular Treatment of Breast Cancer E. Mickiewicz, Argentina 11.40 Molecular Treatment of Melanoma G. Cinat, Argentina 12.00 Discussion 12.30 Personalized medicine S. Siena, Italy 13.00 Closing remarks 13.10 End of the workshop 13.10-14.10 Lunch 8

Workshop Faculty Clarissa Baldotto Instituto Nacional de Câncer Rio de Janeiro, Brazil Wolfgang E. Berdel Department of Medicine University Hospital Muenster Muenster, Germany Carlos Canela Clinica Santa Sofia Caracas, Venezuela Gabriela Cinat Instituto de Oncología Angel Roffo Universidad de Buenos Aires Fundación CIDEA Buenos Aires, Argentina Luis Contreras Clinica Las Condes Las Condes, Santiago,Chile Bernardo Garicochea Hospital São Lucas Porto Alegre, Brazil Jorge León Chong Oncosalud and Instituto Oncologico Miraflores Lima, Peru Hernán Lupera Hospital Metropolitano Quito, Ecuador Clarissa Mathias Núcleo de Oncologia da Bahia and Hospital Português Salvador de Bahia, Brasil 9

Elizabeth Mickiewicz Instituto Angel H. Roffo Universidad de Buenos Aires Buenos Aires, Argentina José Miguel Reyes Clinica Las Condes Santiago, Chile Rachel Riechelmann Instituto do Cancer do Estado de São Paulo Oncology Department São Paulo, Brazil Salvatore Siena Divisione Oncologia Falck Dipartimento Oncologico Ospedale Niguarda Ca' Granda Milan, Italy Carlos Silva Hospital Britanico de Buenos Aires Buenos Aires, Argentina Carlos Vallejos Chairman of the Latin American Education Council Instituto Nacional de Enfermedades Neoplàsticas Lima, Peru 10

General Information Venue The workshop will take place at the: Crowne Plaza Santiago Av. Libertador Bernardo O'Higgins 136 Santiago, Chile Language The official language of this conference will be English. Simultaneous translation will be provided: From English to Spanish and vice versa From English to Portuguese and vice versa Registration fee The registration fee is A 200,00. Registration fee for ESMO members is A 100,00. This fee includes: Workshop coffee breaks and luncheons Workshop dinners Workshop material Certificate of attendance The workshop will start on Friday, November 4 at 10.00 and will close on Saturday, November 5 at 13.00 If you require special assistance (wheelchair, auxiliary aids) or special dietary requirements, please, contact us at info@seronosymposia.org. Hotel accommodation See the enclosed hotel accommodation form. 11

Location Santiago is the capital and largest city of Chile. Chile's steady economic growth has transformed Santiago into one of Latin America's most modern metropolitan areas, with extensive suburban development, and impressive high-rise architecture. Santiago is the industrial and financial center of Chile, it is the regional headquarters to many multinationals. Some international institutions, such as ECLAC (Economic Commission for Latin America and the Caribbean), have their offices in Santiago. The city has a diverse, cosmopolitan culture. Personal data treatment - Informative document In compliance with the article 13 of Italian Legislative Decree n. 196, 30 June 2003, we inform you that your personal data will be processed, with or without the use of electronic or automated means, via suitable tools that will guarantee security and confidentiality. Personal data from you supplied will be communicated to Continuing Medical Education Accreditation Authorities, to agencies that will take care of the whole accreditation process and agencies that will take care of the logistics of the event; should we not receive the below requested data, we will not be able to process your registration to the event. At anytime you may exercise your rights as laid down in the art. 7 of Italian Legislative Decree n. 196, 30 June 2003 of the Italian Law, by contacting the Data Controller Serono Symposia International Foundation (Salita di San Nicola da Tolentino, 1/b - 00187 Rome - Italy) in the person of Data Processor, Michèle Piraux. 12

Mail to: Meridiano Congress International Att: Debora Urbinelli Via Mentana, 2/B 00185 Rome Italy

Registration Form Serono Symposia International Foundation 9 th Latin American Medical Education Workshop on Molecular Targeted Therapy of Cancer Santiago, Chile - November 4-5, 2011 Last Name First Name Academic Title Institution Department Address City State/Country Postal Code Office Telephone Number(s) Mobile Telephone Number(s) Fax Number Registration fee E-mail The registration fee is A 200,00. Registration fee for ESMO members is A 100,00. Payment Payment by Bank Transfer headed to: Meridiano viaggi e turismo S.p.A." BANCA INTERMOBILIARE S.p.A FILIALE DI ROMA - VIA DONIZETTI, 14-00198 ROME - ITALY Account number: 000000003808 IBAN: IT11 C030 4303 2000 0000 0003 808 - SWIFT: BIMTITTTXXX Payment by Credit Card Charge to the following Credit Card (Credit Card commission Fee 3,5%): MasterCard/EuroCard Visa Card Number Exp. Date Card Holder Name (PLEASE PRINT) Card Holder s Signature Date ONLY REGISTRATION FORMS ACCOMPANIED WITH PAYMENT CAN BE PROCESSED Mail to: Debora Urbinelli c/o Meridiano Congress International Via Mentana, 2/B 00185 Rome, Italy T +39 06 88 595 232 F +39 06 88595 234 E-mail: d.urbinelli@meridiano.it All completed Registrations Forms will be acknowledged by mail or fax. Cancellations received in writing before October 5, 2011, 50% refund. After this date no refund will be provided. FOR ANY ACCOMODATION NEED PLEASE CONTACT MERIDIANO CONGRESS INTERNATIONAL

Mail to: Meridiano Congress International Att: Debora Urbinelli Via Mentana, 2/B 00185 Rome Italy

Hotel Accommodation Form Serono Symposia International Foundation 9 th Latin American Medical Education Workshop on Molecular Targeted Therapy of Cancer Santiago, Chile - November 4-5, 2011 Last Name First Name Academic Title Institution Department Address City State/Country Postal Code Office Telephone Number(s) Mobile Telephone Number(s) Fax Number E-mail For hotel reservation, please return the completed form with full prepayment of the requested nights. Hotel Reservation forms without prepayment cannot be processed. DEADLINE FOR RESERVATIONS: September 16, 2011. Accommodation will be subject to availability and requests will be processed on first-come first-served basis. Crowne Plaza Santiago (meeting venue) Double room for single use Breakfast included... 225,00 Double room Breakfast included............... 240,00 Check in Check out (N of nights: ) Rates include city taxes. Payment Payment by Bank Transfer headed to: Meridiano viaggi e turismo S.p.A. BANCA INTERMOBILIARE S.p.A FILIALE DI ROMA - VIA DONIZETTI, 14-00198 ROME - ITALY Account number: 000000003808 IBAN: IT11 C030 4303 2000 0000 0003 808 - SWIFT: BIMTITTTXXX Payment by Credit Card Charge to the following Credit Card (Credit Card commission Fee 3,5%): MasterCard/EuroCard Visa Card Number Exp. Date Card Holder Name (PLEASE PRINT) Card Holder s Signature Date Mail to: Debora Urbinelli c/o Meridiano Congress International Via Mentana, 2/B 00185 Rome, Italy T +39 06 88 595 232 F +39 06 88595 234 E-mail: d.urbinelli@meridiano.it Once you confirm rooms to Meridiano full penalty will be applied in case of cancellation.