IN CHILDREN & ADOLESCENTS

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1 st Under the auspices of the: Hellenic Ministry of Health and Social Solidarity Athens University Medical School International Conference on IN CHILDREN & ADOLESCENTS www.fhchildren2012.com Organized by: The Lipid Clinic and Laboratory for Metabolic Diseases, 1 st Department of Paediatrics, Athens University Medical School In Collaboration with the: Hellenic College of Pαediatricians Hellenic Society of Pαediatric Cardiology Hellenic Cardiological Society Hellenic Heart Foundation Hellenic Society of Lipidiology Atherosclerosis and Vascular Disease Hellenic Society of Atherosclerosis Northern Greece Society of Atherosclerosis 8-9 June 2012 - Athens, Greece Athenaeum Intercontinental Hotel Conference Secretariat www.free-spirit.gr Preliminary Program

Invitation Dear Colleagues, It is both a pleasure and a privilege for me to welcome you, on behalf of the Organizing Committee, to the 1 st International Conference on Familial Hypercholesterolaemia in Children & Adolescents, in Athens, Greece, 8-9 June 2012. Holding the inaugurating Conference in Greece is an extremely opportune circumstance, I believe, since the birthplace of Hippocrates, the father of modern medicine, provides the best setting for the works of the event, which we all hope it will evolve into a major scientific institution worldwide. To that end, the role and contribution of internationally renowned scientists that constitute the faculty of the Conference is of invaluable importance, as you can easily understand from just a brief glance at the scientific program. Furthermore, the topics to be discussed cover the whole spectrum of FH, starting with the genetics and clinical presentation of the condition, overviewing nutritional and drug treatment approaches and, last but not least, enumerating current and future strategies and perspectives in both treatment and prevention. At the same time, we will have the opportunity to exchange views and ideas on the issue of FH in children and adolescents at an idyllic site, right by the waterfront of the Saronic Gulf. A site located right in the middle between the Parthenon and the magnificent Acropolis museum on one part, and Cape Sounion and the Temple of Poseidon on the other. Two gems of antiquity that show in the most persuasive manner why the 5 th century b.c. was considered as the golden age of the city-state of Athens, which, in turn, is considered as the birthplace of western civilization. With these words and a warm welcome to Greece, we look forward to seeing you all in Athens in 2012, another benchmark year for the ancient Greek spirit, since it is an Olympic Games year! For the Organizing Committee Euridiki Drogari President

Scientific Committee Barbir Mahmoud (UK) Benlian Pascale (FRANCE) Cariolou Marios (CYPRUS) Deanfield John (UK) Defesche Joep (The NETHERLANDS) Descamps Olivier (BELGIUM) Drogari Euridiki (GREECE) Efthimiadis Apostolos (GREECE) Elisaf Moses (GREECE) Hadjic Nedim (UK) Hobbs Helen (USA) Humphries Steve (UK) Kafatos Antonios (GREECE) Karvounis Haralambos (GREECE) Lekakis John (GREECE) Manolopoulos Evangelos (GREECE) Ose Leiv (NORWAY) Parcharidis George (GREECE) Pitsavos Christos (GREECE) Plat Jogchem (The NETHERLANDS) Richter Dimitrios (GREECE) Stefanadis Christodoulos (GREECE) Soutar Anne (UK) Stein Evan (USA) Steinhagen-Thiessen Elisabeth (GERMANY) Toutouzas Pavlos (GREECE) Tsitouris George (GREECE) Wade-Martins Richard (UK) Wiegman Albert (The NETHERLANDS) Zampelas Antonios (GREECE) Zannis Vassilios (USA) Organizing Committee Chair: Euridiki Drogari (GREECE) Athyros Vassilios (GREECE) Bakoula Chryssa (GREECE) Chrousos George (GREECE) Hadjic Nedim (UK) Hassapidou Maria (GREECE) Hobbs Helen (USA) Humphries Steve (UK) Ifanti Georgia (GREECE) Kolovou Genovefa (GREECE) Milionis Charalambos (GREECE) Papagiannis John (GREECE) Paphitis Christos (GREECE) Rallidis Loukianos (GREECE) Stamatelopoulos Kimon (GREECE) Stein Evan (USA) Tavridou Anna (GREECE) Vlachos Antonios (GREECE) Wiegman Albert (The NETHERLANDS) Zannis Vassilios (USA)

Scientific Program Friday, June 8 th 2012 08:00-09:00 Registrations 09:00-11:30 GENETICS OF FH Moderators: Zannis Vassilis (USA) Cariolou Marios (CYPRUS) Genetics of lipids and cardiovascular disease: getting to the heart of the matter Hobbs Helen (USA) Old and new genes causing FH Soutar Anne (UK) Need for molecular diagnosis of FH Humphries Steve (UK) Correlation genotype / phenotype in FH Defesche Joep (The NETHERLANDS) 11:30-12:00 Coffee Break 12:00-13:15 Poster Session 13:15-15:15 Break - Light Lunch 15:15-16:30 Poster Session 16:30-18:00 CLINICAL PRESENTATION Moderators: Lekakis John (GREECE) Richter Dimitrios (GREECE) Natural history of FH Drogari Euridiki (GREECE) Structural and functional changes in the arterial wall before and after treatment for FH in adolescents Deanfield John (UK) 18:00-18:30 Coffee Break 18:30-19:45 Satellite Symposium 19:45-20:30 Opening Ceremony 21:30 Welcome Reception

Scientific Program Saturday, June 9 th 2012 08:45-10:00 TREATMENT WITH NUTRITION Moderators: Kafatos Antonios (GREECE) Ηassapidou Maria (GREECE) Nutritional approach and guidelines for FH paediatric population Zampelas Antonios (GREECE) The role of sterols/stanols in the treatment of children and adolescents with FH Plat Jogchem (The NETHERLANDS) 10:00-10:30 Coffee Break 10:30-13:45 DRUG TREATMENT: THE INTERNATIONAL EXPERIENCE Moderators: Parcharidis Georgios (GREECE) Karvounis Haralambos (GREECE) Drug treatment: the Norwegian experience Ose Leiv (NORWAY) Drug treatment: the Dutch experience Wiegman Albert (The NETHERLANDS) Drug treatment: the Belgian experience Descamps Olivier (BELGIUM) Drug treatment for children and adolescents with FH-present and future Stein Evan (USA) Pharmacogenomics of statin effects in children and adults with FH Manolopoulos Evangelos (GREECE) 13:45-14:45 Satellite Symposium 14:45-16:15 Break - Light Lunch 16:15-18:30 TREATMENT/ADVANCES AND CHALLENGES Moderators: Elisaf Moses (GREECE) Pitsavos Christos (GREECE) LDL - Apheresis in FH: the German experience Steinhagen - Thiessen Elisabeth (GERMANY) LDL - Apheresis in FH: the British experience Barbir Mahmoud (UK) Liver Transplantation Hadzic Nedim (UK) Gene Therapy Wade-Martins Richard (UK) 18:30-19:00 Coffee Break 19:00-19:45 PREVENTION Moderators: Chrousos Georgios(GREECE) Bakoula Chryssa (GREECE) Earlier is the better: adulthood phenotype in grown-up genetically defined FH children treated since early childhood Benlian Pascale (FRANCE) 19:45-21:00 Satellite Symposium 21:30 Official Dinner

General Information Conference Venue - Date Athenaeum Intercontinental Hotel, Athens June, 8-9, 2012 Official Language The official language of the Conference is English. Registration Fees REGISTRATION TYPE Delegates Trainees Dieticians/Nurses Students Until 31 st January 2012 From 1 st February 2012 until 30 th April 2012 1 st May 2012 On-Site 290 240 370 300 490 370 130 130 130 FREE (The abovementioned prices include all legal taxes) Registration fees cover: Access to the scientific sessions and exhibition area Conference material (bag, book of abstracts, certificate of attendance) Coffee breaks and light lunches during the Conference Welcome Reception (Friday, June 8 th ) Official Dinner (Saturday, June 9 th )

General Information Abstract Submission Deadline for abstracts: January 31 st, 2012 Abstracts on Familial Hypercholesterolaemia in children and adolescents are invited from all participants for poster presentation All abstracts should be submitted in English through the electronic form in the conference website. Please, do not use other means of submission (e.g. mail, e-mail) The text must contain 250 words maximum The title of the abstract must be written in capital letters, with maximum length 1-2 lines Abstract texts should have the following structure: introduction, purpose, methods, results and conclusion The names of the authors must be in the nominative case, first the surname and then the first name and the name of the presenter should be underlined. Please provide e-mail and phone number for communication with the presenter All received abstracts will be evaluated by the Scientifc Committee After the submission of the abstract no change can be made by the author A confirmation of receipt will be sent to your e- mail address. For any inquiries, please contact Mrs. Maria Schismenou (Tel:+30 210 6048260, E- mail: mschismenou@free-spirit.gr) Corresponding authors will be informed by Friday, March 30 th 2012, whether their abstracts have been accepted or not The dimensions of the posters should be 1,50m height x 0,80m width and they will be displayed and presented during the conference The posters will be presented in an interactive poster session. The authors will be asked to discuss their findings in small groups during the poster session and to answer the attendees questions Please ensure that your poster is readable from about 2-3 meters distance A registration fee of 290 applies for every approved abstract. Please note that this fee is applicable for each approved abstract separately, even if submitted by the same author Payment details about the 1 st International Conference on Familial Hypercholesterolaemia in children and adolescents : CYPRUS BANK IBAN: GR72 0730 1760 0000 0003 5109 018 SWIFT CODE: BCYPGRAA NAME:I.VOUTSAS-A. MASTORAS LTD It is important to send a copy of the receipt of your payment to mschismenou@free-spirit.gr or Fax: +30 210 6047457

General Information Accommodation Packages a) Participants: 780 The cost of the package includes: Three (3) night stay including breakfast at the Conference Hotel b) Accompanying Persons: 160 The cost of the package includes: Three (3) night stay including breakfast at the Conference Hotel Welcome Reception (Friday, June 8 th ) Official Dinner (Saturday, June 9 th ) The packages do not include: Airfare VAT (23%) Registration fees Hotel Information Athenaeum Intercontinental Hotel The Athenaeum Intercontinental has been named Greece s leading hotel time and again. Athens largest guestrooms, award winning fine dining venues and a central location appeal to business and leisure travellers alike. Within a few kilometres are the Acropolis, the Parthenon, the Temple of Apollo, the Plaka and the Lycabettus Hill. Metro and tram stations are also nearby. Syngrou Avenue 89-93, Athens, 11745, Grecce Front Desk: +30 210 9206000, Fax: +30 210 9206500 Web site: http://www.ichotelsgroup.com/intercontinental/en/gb/locations/athens Contact Information Conference Secretariat 12 Thessalonikis Street, GR 15344 Gerakas, Attiki, Greece Tel.: +30 210 6048260, Fax: +30 210 6047457, Web site: www.free-spirit.gr Project Manager: Maria Schismenou, E-mail: mschismenou@free-spirit.gr