Supplementary Figure 1: Clinical Criteria by State.

Supplementary Figure 1: Clinical Criteria by State. Color Code Fibrosis State used to be in this category but is no longer in this category State is newly in this category n Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware DC Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming None indicated 7 AL GA ME MS NV UT WY F0 7 CT FL MA MN NH NY WA F1 0 F2 14 AK CA CO DC IN MD NJ NM NC ND OK PA VA WI F3 21 AZ AR DE ID IA KS KY LA MI MO MT NE OH OR RI SC SD TN TX VT WV F4 1 IL Not in Table 1 HI Decompensated Cirrhosis None Indicated 15 AL AR CA CT GA MO MT NJ NY OR PA SC SD VA WY Eligible 29 AK CO DE DC FL ID IN IA KS LA ME MD MA MI MS NE NV NM NC ND OH OK RI TN TX UT VT WV WI Ineligible 5 AZ IL KY MN WA Not in table 2 HI NH Biopsy Not required 34 AK AZ AR CA CO CT DE FL ID IL IA KY LA MD MA MI MN MT NE NJ NC ND OH OK OR PA RI SC TN TX VA WA WV WI Required 1 SD Unclear 13 AL DC GA IN KS ME MS MO NV NY UT VT WY Not in table 3 HI NH NM Inquires about HIV status Yes 27 AL AK AZ CA CO DE DC FL ID LA MD MA MI MS NE NH NM OH OR RI SC TX VT VA WV WI WY Covered if HIV+ Regardless of Fibrosis Stage Yes 7 CA DE IN NE NJ PA VA Requires pt to be on ARVs, to have controlled VL, or certain CD4 count Yes 6 AZ, DE, DC, FL, NY, OH, Prescriber Restriction None indicated 15 AL AK CA CT DE GA MD MA MO NE NV NH NM NC WY By or in consultati 22 AZ CO DC FL ID IL IN KS KY ME MI MN MS NY ND OK OR UT VT VA WA WV By specialist 12 AR IA LA MT NJ OH PA RI SD TN TX WI Unclear 1 SC Not in table 1 HI

Requires Period of Abstinance Regardless of Abuse History none indicated 28 AL AK AZ AR CA CT DE DC GA IN MD MA MI MO NE NV NJ NY NC OR PA RI TX UT VA WA WI WY 1 month 1 FL 3 months 2 IA WV 6 months 14 CO ID KS KY ME MN MS MT OH OK SC SD TN VT 12 months 3 IL LA ND Requires Period of Abstinance for Persons with a History of Abuse none indicated 43 AL AK AR CA CO CT DE DC FL GA IL IN IA KS KY LA ME MD MA MI MN MS MO MT NV NJ NY NC ND OH OK OR PA SC SD TN TX UT VT VA WA WV WY 3 months 0 6 months 5 AZ ID NE RI WI Drug/EtOH Screen Required none indicated 29 AR CA CT DC GA IN KS MD MA MI MN MT NV NJ NY NC ND OH OK OR PA RI SC SD TN UT WA WV WI Patients with histo 3 ME MS VT Everyone 16 AL AK AZ CO DE FL ID IL IA KY LA MO NE TX VA WY Requires clinical evaluation for substance use disorder None indicated 44 AL AK AZ AR CA CO CT DE DC FL GA ID IL IN IA KS LA ME MD MA MI MN MS MO MT NV NJ NY NC ND OH OK PA RI SC SD TN TX UT VT WA WV WI WY Yes 4 KY NE OR VA 0 Random/Periodic Drug Screening During Treatment None indicated 39 AL AK AR CA CT DE DC FL GA IN IA KS ME MD MA MI MN MS MO MT NE NV NJ NY ND OH OR PA RI SC SD TN TX UT VT VA WA WI WY Everyone 2 KY WV Patients with histo 7 AZ CO ID IL LA NC OK

Drugs Covered - Preferred Daklinza 41 AL AK AZ AR CO CT DE DC FL GA ID IL IN IA KS LA ME MD MA MI MS NE NH NY ND OH OK OR PA RI SC SD TN TX UT VT VA WA WV WI WY Epclusa 18 AL AR CO CT DC ID IL KS LA MA MI MN MT NC UT WA WI WY Harvoni 47 AL AK AZ AR CA CO CT DE DC FL GA ID IL IN IA KS LA ME MD MA MI MN MS MO MT NE NV NH NY NC ND OH OK OR PA RI SC SD TN TX UT VT VA WA WV WI WY Olysio 43 AL AZ AR CO CT DC FL GA ID IL IN IA KS LA ME MD MA MI MN MS MO MT NE NV NH NY NC ND OH OK PA RI SC SD TN TX UT VT VA WA WV WI WY Sovaldi 44 AL AK AZ AR CA CO CT DE DC GA ID IL IN IA KS LA ME MD MA MI MN MS MO MT NE NV NH NY NC ND OH OK OR PA RI SD TN TX UT VT VA WA WV WY Technivie 43 AL AK AZ AR CO CT DE DC FL GA ID IL ILIN IA KS LA ME MD MA MI MN MS MT NE NH NY NC ND OH OK PA RI SC SD TN TX UT VT VA WA WV WI WY Viekira Pak 39 AL AK AZ AR CA CO CT DE DC FL GA ID LA ME MA MI MN MS MO MT NE NV NH NY NC ND OH OK RI SC SD TN TX UT VA WA WV WI WY Viekira XR 8 CT DC MI MN SD UT WI WY Zepatier 39 AL AZ AR CA CO CT DE DC FL GA ID IL IN IA KS LA ME MD MA MI MN MS MT NE NH NY NC ND OK PA RI SD TN UT VA WA WV WI WY Information not av 3 HI KY NJ Key: Bold = preferred Restriction on patients with CKD or ESRD Excluded if CrCl 3 6 AZ MN NJ OH OR TX None indicated 41 AL AK AR CA CO CT DE DC FL GA ID IL IN IA KS KY LA ME MD MA MI MS MO MT NE NV NY NC ND OK PA RI SC SD TN UT VT VA WV WI WY Unclear 1 WA Not in table 3 HI NH NM Patient Contract or Documentation of "Committment" Yes 10 DC IL LA MI MT ND OH OK PA WV None indicated 0 Not in table 41 AL AK AZ AR CA CO CT DE FL GA HI ID IN IA KS KY ME MD MA MN MS MO NE NV NH NJ NM NY NC OR RI SC SD TN TX UT VT VA WA WI WY

Supplementary Table 1: Online Sources of Clinical Criteria. State Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware DC Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky URL for Documents http://medicaid.alabama.gov/content/5.0_resources/5.4_forms_library/5.4.5_pharmacy_forms.aspx http://dhss.alaska.gov/dhcs/pages/pharmacy/medpriorauthoriz.aspx - - > "Infectious Disease" https://www.azahcccs.gov/shared/medicalpolicymanual/ - - > Medical Policy Manual Chapter 300.pdf - - > Page 320-36 HCV Rx Request Sheet: https://arkansas.magellanrx.com/provider/documents/ - - > "Hep C Treatment Form" Prior Auth Criteria: https://arkansas.magellanrx.com/provider/documents/ - - > "Pharmacy" - - > "Memorandum" - - > https://arkansas.magellanrx.com/provider/docs/provider_memos/provmem- 20160608.pdf PDL: https://arkansas.magellanrx.com/provider/docs/rxinfo/pdl.pdf Non- injectable drugs: http://files.medi- cal.ca.gov/pubsdoco/manual/man_query.asp?wsearch=%28%23filename+%2a_%2ao00%2a%2edoc+or+%23filename+%2a_%2ao00%2a%2ezip+or+%23f ilename+%2a_%2ao03%2a%2edoc+or+%23filename+%2a_%2ao03%2a%2ezip+or+%23filename+%2a_%2az00%2a%2edoc+or+%23filename+%2a_%2az 00%2A%2Ezip+OR+%23filename+%2A_%2Az02%2A%2Edoc+OR+%23filename+%2A_%2Az02%2A%2Ezip%29&wFLogo=Part+2+%26%231%3B+Clinics+and +Hospitals+%28CAH%29&wFLogoH=53&wFLogoW=564&wAlt=Part+2+%26%231%3B+Clinics+and+Hospitals+%28CAH%29&wPath=N - - > "Non- Injectable Drugs (non inject)" PDL: https://www.colorado.gov/hcpf/provider- forms#pdl PA: https://www.colorado.gov/hcpf/provider- forms - - > "Pharmacy" PA Form: https://www.ctdssmap.com/ctportal/pharmacyinformation/tabid/65/default.aspx http://www.dmap.state.de.us/information/paforms.html - - > "Hepatitis C Agents" PDL: https://dc.fhsc.com/providers/pdl.asp Patient Contract: https://www.dc- medicaid.com/dcwebportal/providerspecificinformation/providerinformation - - > Cntl - F for hepatitis C - - > https://www.dc- medicaid.com/dcwebportal/documentinformation/getdocument/12835 PA and policies: http://www.dc- pbm.com PDL: http://ahca.myflorida.com/medicaid/prescribed_drug/pharm_thera/fmpdl.shtml Criteria and PA form: http://ahca.myflorida.com/medicaid/prescribed_drug/drug_criteria.shtml PDL: https://dch.georgia.gov/2016- preferred- drug- list - - > "Drug Class" Criteria: https://dch.georgia.gov/prior- authorization- process- and- criteria#h - - > "Hepatitis C" No criteria available. PA form, PDL, Criteria: http://healthandwelfare.idaho.gov/medical/prescriptiondrugs/priorauthorizationforms/tabid/206/default.aspx - - > "Hepatitis C Agents," "Hepatitis C Agents Therapeutic Criteria," and "Preferred Drug List" https://www.illinois.gov/hfs/medicalproviders/pharmacy/pages/criteriaandforms.aspx https://inm.providerportal.catamaranrx.com/providerportal/faces/prelogin.jsp - - > "Preferred Drug List" - - > "Prior authorization forms" http://www.iowamedicaidpdl.com/pa_forms PDL: http://www.kdheks.gov/hcf/pharmacy/pharmacy_druglist_auth_forms.html PA Criteria: http://www.kdheks.gov/hcf/pharmacy/pa_criteria.htm Provider Notice: https://kyportal.magellanmedicaid.com/provider/public/documents.xhtml Commissioner Decisions: http://chfs.ky.gov/dms/pt.htm

Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana PDL: https://kyportal.magellanmedicaid.com/provider/public/home.xhtml HCV PA Checklist, PA Form: http://www.lamedicaid.com/provweb1/forms/forms.htm Criteria: http://www.lamedicaid.com/provweb1/pharmacy/pharmacyindex.htm Criteria and PDL: http://www.mainecarepdl.org/pafiles Criteria and PA Forms: https://dhmh.maryland.gov/pap/pages/hepatitis- C- Therapy.aspx PDL: https://dhmh.maryland.gov/pap/pages/druglist.aspx Criteria: https://masshealthdruglist.ehs.state.ma.us/mhdl/pubtheradetail.do?id=44 PA Form: https://masshealthdruglist.ehs.state.ma.us/mhdl/pubpa.do;jsessionid=29aea3a7402dee49dd97b20ad2210c?category=prior+authorization+forms+for +Pharmacy+Services PA Form and Criteria: https://michigan.fhsc.com/providers/forms.asp Criteria and PA Form: http://www.dhs.state.mn.us/main/idcplg?idcservice=get_dynamic_conversion&revisionselectionmethod=latestreleased&ddocname=dhs16_194008 # PDL: https://medicaid.ms.gov/providers/pharmacy/preferred- drug- list/ PA Form and Criteria (PA form instructions): https://medicaid.ms.gov/providers/pharmacy/pharmacy- resources/ PDL and Criteria: http://dss.mo.gov/mhd/cs/pharmacy/pages/clinedit.htm PA Form: http://manuals.momed.com/manuals/presentation/forms.jsp PDL: https://medicaidprovider.mt.gov/ - > Preferred Drug List PA Form: http://medicaidprovider.mt.gov/forms#240933498- forms- p- - z - - > Prior Authorization Request Hepatitis C Treatment Nebraska Criteria: https://nebraska.fhsc.com/priorauth/clinicalcriteria.asp - - > "Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor" and "Hepatitis C" PDL: https://nebraska.fhsc.com/downloads/pdl/ne_pdl.pdf PA Form: https://nebraska.fhsc.com/priorauth/paforms.asp - > "Hepatitis C" Nevada New Hampshire PDL: https://www.medicaid.nv.gov/providers/rx/pdl.aspx Medicaid services manual (Criteria): http://dhcfp.nv.gov/resources/adminsupport/manuals/msm/c1200/chapter1200/ PA Form: http://www.dhhs.nh.gov/ombp/pharmacy/authorization.htm PDL: http://www.dhhs.nh.gov/ombp/pharmacy/index.htm Pharmacy benefit updates: http://www.wellsense.org/providers/news New Jersey New Mexico New York North Carolina North Dakota Criteria not available on website (https://www.njmmis.com/default.aspx) PA, checklist, and Provider News Bulletin with criteria: http://www.molinahealthcare.com/providers/nm/medicaid/forms/pages/fuf.aspx PA checklist, notifications, and criteria: https://newyork.fhsc.com/providers/pdp_hepatitisc.asp http://www.health.ny.gov/health_care/medicaid/ Criteria: https://www.nctracks.nc.gov/content/public/providers/pharmacy/pa- drugs- criteria- new- format.html Readiness Criteria, PA Forms, and Continuation Forms: https://nctracks.nc.gov/content/public/providers/pharmacy/forms.html PDL: http://dma.ncdhhs.gov/document/preferred- drug- list http://www.hidesigns.com/ndmedicaid PDL: http://www.hidesigns.com/ndmedicaid/pdl/2016.html

Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia PA forms: http://www.hidesigns.com/ndmedicaid/pa- forms.html PA criteria: http://www.hidesigns.com/ndmedicaid/pa- criteria.html https://www.nd.gov/dhs/services/medicalserv/medicaid/provider- pharmacy.html http://pharmacy.medicaid.ohio.gov/ PA form: http://pharmacy.medicaid.ohio.gov/prior- authorization PDL and criteria: http://pharmacy.medicaid.ohio.gov/drug- coverage - > http://pharmacy.medicaid.ohio.gov/sites/default/files/20160413- ohio- pdl.pdf Criteria and PA forms: http://www.okhca.org/providers.aspx?id=16000 PDL: http://www.oregon.gov/oha/healthplan/pages/pdl.aspx PA Criteria: http://www.oregon.gov/oha/healthplan/pages/pharmacy- policy.aspx PDL: https://papdl.com/preferred- drug- list PA: http://www.dhs.pa.gov/provider/pharmacyservices/drugsrequiringclinical priorauthorization/index.htm Bulletins: http://www.dhs.pa.gov/provider/bulletinsearch/index.htm (http://www.dhs.pa.gov/cs/groups/webcontent/documents/bulletin_admin/c_194652.pdf) PA Form, PPS form, Pt contract: http://www.eohhs.ri.gov/providerspartners/generalinformation/providerdirectories/pharmacy/pharmacypriorauthorizationprogram.aspx PDL: http://www.eohhs.ri.gov/providerspartners/generalinformation/providerdirectories/pharmacy/pharmacytherapeuticscommittee.aspx HCV Criteria: http://www.eohhs.ri.gov/providerspartners/generalinformation/providerdirectories/pharmacy.aspx - - > http://www.eohhs.ri.gov/portals/0/uploads/documents/pa22%20policy.pdf PA form: http://southcarolina.fhsc.com/providers/rxdocuments.asp PDL: http://southcarolina.fhsc.com/providers/pdl.asp PA form: http://www.hidesigns.com/sdmedicaid/sdpa.html PA criteria: http://www.hidesigns.com/sdmedicaid/sdpacriteria.html PDL: https://tenncare.magellanhealth.com/tenncare_portal/spring/main?execution=e1s2 PA and criteria: https://tenncare.magellanhealth.com/tenncare_portal/spring/main?execution=e1s4 PA forms: https://tenncare.magellanhealth.com/tenncare_portal/spring/main?execution=e1s6 PA Criteria: https://paxpress.txpa.hidinc.com/apex/f?p=1003:1:952782074022698::no PDL: http://www.txvendordrug.com/formulary/preferred- drugs.shtml PA: https://medicaid.utah.gov/pharmacy/prior- authorization PDL: https://medicaid.utah.gov/pharmacy/preferred- drug- list Criteria: https://medicaid.utah.gov/utah- medicaid- official- publications?p=medicaid%20provider%20manuals/pharmacy/attachments/ PA: http://dvha.vermont.gov/for- providers/pharmacy- prior- authorization- request- forms PDL and criteria: http://dvha.vermont.gov/for- providers/preferred- drug- list- clinical- criteria/view PDL/Criteria: https://www.virginiamedicaidpharmacyservices.com/asp/pdl.asp PA Form: https://www.virginiamedicaidpharmacyservices.com/asp/authorizations.asp Criteria and PA Form: http://www.hca.wa.gov/billers- providers/programs- and- services/pharmacy PDL: http://www.hca.wa.gov/billers- providers/claims- and- billing/professional- rates- and- billing- guides#collapse43 PDL: http://www.dhhr.wv.gov/bms/bms%20pharmacy/pages/preferred- Drug- List.aspx Criteria: http://www.dhhr.wv.gov/bms/bms%20pharmacy/pages/pa- Criteria.aspx PA Form, renewal form, Attachment, Pt consent: http://www.dhhr.wv.gov/bms/bms%20pharmacy/pages/pa- Forms.aspx

Wisconsin Wyoming Criteria, PA Form, Renewal Form (webpage): https://www.forwardhealth.wi.gov/wiportal/subsystem/kw/display.aspx?ia=1&p=1&sa=48&s=3&c=345&nt=hepatitis+c+agents Criteria: https://www.forwardhealth.wi.gov/wiportal/content/provider/updates/pharmacy.htm.spage - > "Revised Prior Authorization Forms and Changes to Pharmacy Policies for Hepatitis C Agents" PA form, instructions, and renewal form: https://www.forwardhealth.wi.gov/wiportal/content/provider/forms/index.htm.spage# - > "Prior Authorization Drug Attachment for Hepatitis C Agents" PDL (quick reference): https://www.forwardhealth.wi.gov/wiportal/content/provider/medicaid/pharmacy/resources.htm.spage# - > "Preferred Drug List Quick Reference" PA form: http://www.wymedicaid.org/pa PDL: http://www.wymedicaid.org/pdl