NATIONAL EPIDEMIOLOGICAL STUDY OF ACUTE MYELOID LEUKEMIA (AML) IN ALGERIA OVER A PERIOD OF 5 YEARS ( )
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1 NATIONAL EPIDEMIOLOGICAL STUDY OF ACUTE MYELOID LEUKEMIA (AML) IN ALGERIA OVER A PERIOD OF 5 YEARS ( ) A multicentric cooperative study of the AML and Myelodysplasia Algerian Work Group Bekadja MA, (National Group Coordinator), Hamladji RM (CPMC, Alger), Belhani M (CHU Benimessous, Alger), Ardjoun FZ (HCA, Alger), Abad MT(CAC Blida), Touhami H (CHU Oran), Ait Ali H (CHU Tizi Ouzou), Zouaoui Z (CHU Sidi Bel Abbes), Sidimansour N (CHU Constantine), Mesli N (CHU Tlemcen), Hamdi S (CHU Sétif), Grifi F (CHU Annaba), Saidi M (CHU Batna), Bachiri A (HMRU Oran) XI ème Congrès Maghrébin d Hématologie. Agadir Mai
2 XI ème Congrès Maghrébin d Hématologie. Agadir Mai
3 1 Première étude nationale, : M. BENAKLI (Revue Algérienne d Hématologie N 00) XI ème Congrès Maghrébin d Hématologie. Agadir Mai
4 1 Groupe Algérien d Etude des LAM / MDS i. Etat des lieux ii. iii. Prise en charge consensuelle diagnostique et thérapeutique Système d information sanitaire (data fiables pour stratégie de soin) 2 Deuxième étude nationale, XI ème Congrès Maghrébin d Hématologie. Agadir Mai
5 XI ème Congrès Maghrébin d Hématologie. Agadir Mai
6 STUDY OBJECTIVE 1 AML epidemiological caracteristics 2 3 AML incidence within the Algerian population Survey Impact XI ème Congrès Maghrébin d Hématologie. Agadir Mai
7 PATIENTS and METHODS Pre-established form Diagnosis of acute leukemia Inclusion age (adults) Data collection & processing Centre (EHU) o Results In relation to geographic data In relation to anthropologic data In relation to pathology XI ème Congrès Maghrébin d Hématologie. Agadir Mai
8 Pre-established form XI ème Congrès Maghrébin d Hématologie. Agadir Mai
9 RESULTS XI ème Congrès Maghrébin d Hématologie. Agadir Mai
10 RESULTS IN RELATION TO GEOGRAPHIC DATA IN RELATION TO ANTHROPOLOGIC DATA IN RELATION TO PATHOLOGY XI ème Congrès Maghrébin d Hématologie. Agadir Mai
11 Blida Sidi Bel Abbes XI ème Congrès Maghrébin d Hématologie. Agadir Mai
12 WEST 19% CENTER 45% EAST 36% XI ème Congrès Maghrébin d Hématologie. Agadir Mai
13 AML distribution according to the place of enrollement CENTER 45% EAST 36% 12% 10% WEST 19% 12% 10% 12% 12% 11% 10% 8% 9% 8% 6% 4% 2% 3% 1% 2% 2% 1% 3% 4% 0% XI ème Congrès Maghrébin d Hématologie. Agadir Mai
14 RESULTS IN RELATION TO GEOGRAPHIC DATA IN RELATION TO ANTHROPOLOGIC DATA IN RELATION TO PATHOLOGY XI ème Congrès Maghrébin d Hématologie. Agadir Mai
15 Clinical characteristics of patients at diagnosis Number of Patients 1426 Median age 44,7 (16-82) Male 41,1 Female 44,6 Sex ratio 1,16 XI ème Congrès Maghrébin d Hématologie. Agadir Mai
16 RESULTS IN RELATION TO GEOGRAPHIC DATA IN RELATION TO ANTHROPOLOGIC DATA IN RELATION TO PATHOLOGY XI ème Congrès Maghrébin d Hématologie. Agadir Mai
17 FREQUENCY OF AML DIAGNOSIS METHODS 80 % MEDIAN RANGE ,6 % White blood cell count (10 9 /L) 7,5 % Hemoglobin (g/l) Platelets (10 9 /L) ,6 % XI ème Congrès Maghrébin d Hématologie. Agadir Mai
18 AML FREQUENCY ACCORDING TO FAB CLASSIFICATION % 40% 36% 35% 30% 25% 20% 15% 13% 9% 14% 14% 10% 5% 2% 4% 1% 7% 0% M0 M1 M2 M3 M4 M5 M6 M7 UnCl AML XI ème Congrès Maghrébin d Hématologie. Agadir Mai
19 AML DISTRIBUTION ACCORDING TO THE YEAR OF DIAGNOSIS ,5% ,9% ,8% 18,2% 20,6% XI ème Congrès Maghrébin d Hématologie. Agadir Mai
20 CRUDE ANNUAL AML INCIDENCE (FOR Hbts) PER DIAGNOSIS YEAR 1,6 1,4 1,2 1 0,8 0,6 0,4 0,2 0 Taux Incidence pour 0,84 0,85 0,91 0,70 0, XI ème Congrès Maghrébin d Hématologie. Agadir Mai
21 AML DISTRIBUTION ACCORDING TO THE AGE-STANDARDIZED INCIDENCE 4,00 3,50 Taux d incidence pour ,38 3,00 2,50 2,00 2,65 3,27 1,50 1,12 1,00 0,50 0,41 0,62 0,96 1,57 0,00 < XI ème Congrès Maghrébin d Hématologie. Agadir Mai
22 DISCUSSION XI ème Congrès Maghrébin d Hématologie. Agadir Mai
23 DIAGNOSTIC METHODS 80% 80% 70% 62% 60% 50% 40% 30% 28% 20% 10% 11% 0,40% 4% 8% 0% Cytochemistry Cytometry Cytogenetics Molecular Biology *M. BENAKLI, revue Algérienne hématologie, N 00 mars 2009 XI ème Congrès Maghrébin d Hématologie. Agadir Mai
24 AML ANNUAL INCIDENCE * Number of Patients Median age 39 (1-92) 44,7 (16-82) Sex ratio 1,08 1,16 Annual Incidence 0,67 / hbts 0,91 / hbts (0,33 on 1995; 0,67 on 2005). Level of incidence has been doubled within the interval of ten years *M. BENAKLI, revue Algérienne hématologie, N 00 mars 2009 XI ème Congrès Maghrébin d Hématologie. Agadir Mai
25 DISTIBUTION OF AML & ALL CASES ACCORDING TO YEAR OF DIAGNOSIS ALL AML XI ème Congrès Maghrébin d Hématologie. Agadir Mai N. Boudjerra, RAH, N 00, Sept 2009
26 DISTRIBUTION OF AML \ ALL RATIO ACCORDING TO THE 2 AGE GROUPS 100% 90% 80% 70% ALL 20 years 52% ALL > 20 years 30% 60% 50% 40% 30% 20% AML 20 years 48% AML > 20 years 70% 10% 0% AML\ALL ratio 0,91 2,36 XI ème Congrès Maghrébin d Hématologie. Agadir Mai N. Boudjerra, RAH, N 00, Sept 2009
27 CONCLUSION XI ème Congrès Maghrébin d Hématologie. Agadir Mai
28 STUDY IMPACT (1) cytochimistry STUDY National data for the registry of ALs Diagnostic means planification Flowcytometry cytogenetics Molecular biology XI ème Congrès Maghrébin d Hématologie. Agadir Mai
29 STUDY IMPACT (2) Young patients (40 years vs 60 years) Supportive care STUDY National data for the registry of ALs Therapeutic strategy adaptation chemotherapy highly-propable casting role of HSCT XI ème Congrès Maghrébin d Hématologie. Agadir Mai
30 Blida Sidi Bel Abbes XI ème Congrès Maghrébin d Hématologie. Agadir Mai
31 Blida Sidi Bel Abbes XI ème Congrès Maghrébin d Hématologie. Agadir Mai
32 Aknowledgement Abdennebi N, Belhadri F, Moussaoui, Boukhemia F, Ait Ameur N, Tensaout F, Ahmed Nacer R, Hamladji RM : Hématologie et GMO CPMC Alger Kaci Z, BouicheL, Bernine S, Ahmidatou, H, Boutbiba, Hadidi, Boutiba, Achoui, Nekkal S, Belhani: CHU Beni Messous Taebi, Attari, Kellouche, Mansour, Sahraoui, Ardjoun FZ : HCA-Ain Naadja Berraf S, Abad MT : CAC Blida Zouani S,Touhami H : CHU Oran Allouda M, Dali N, Ait Ali H: CHU Tizi-Ouzou Zouaoui Z: CHU Sidi-Bel-Abbès Osmani S, Bekadja MA: EHU 1er novembre Oran Himour I, Benhalilou M, Berrahma I, Sidimansour N : CHU Constantine Dali M, Benkhodja FZ, Bentahar I, Amoura A, Hamdi S : CHU Sétif Ouled Diaf, Smaili, Grifi F: CHU Annaba Mesli N: CHU Tlemcen Saidi M: CHU Batna Mehalhal N: EPH Mascara Bachiri A : HMRUO XI ème Congrès Maghrébin d Hématologie. Agadir Mai
33 XI ème Congrès Maghrébin d Hématologie. Agadir Mai
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