Curriculum Vitae. Ramsés Galaz Mendez, PhD WORK EXPERIENCE

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1 Curriculum Vitae Ramsés Galaz Mendez, PhD WORK EXPERIENCE CEO / Owner. GSE Biomedical (GALAZ SCIENCE AND ENGINEERING SA DE CV). A company with the purpose of designing, manufacturing and distributing class I, II and III medical devices to the Latin American market. September 2004 present. COO / Co-founder / shareholder. ZIPTEK LLC (Sarasota, FL) and ZIPTEK MEXICO SA DE CV. An orthopaedic medical device company focusing on designing, producing and worldwide distribution of proprietary technology for knotless and bioabsorbable tissue repair systems in orthopaedic surgery. March 2012 present. Director of Research, Office of Technology Transfer, Graduate Studies, and Continuing Education. Instituto Tecnológico y de Estudios Superiores de Monterrey. Sonora Norte Campus. November 2011 December I coordinated all research and tech transfer activities in the campus (areas include solar biomedical engineering, renewable energy, automation, mechanical design, mining applications) as well as the pursuit of funding through grants and consulting project with local and national industries. 4.1 Million USD in grant funds received during the November 2011-present in numerous projects with companies and CONACYT. Professor, Instituto Tecnológico y de Estudios Superiores de Monterrey. Monterrey Campus (Department of Biomedical Engineering Faculty of Medicine), Mexico City Campus (Department of Biomedical Engineering), Laguna Campus (Biotechnology Department) and Sonora Norte Campus (Department of Mechatronics Engineering). August present. Courses taught at the institution: o Cardiovascular Engineering (videoconference to Monterrey Campus) o Biomechanics (videoconference to Monterrey and Mexico City Campus) o Advanced Biomechanics (videoconference to Monterrey Campus) o Medical Technologies (videoconference to Laguna Campus) o Mechatronics Engineering Project o Applied Mechanics o Computational Finite Element Analysis o Manufacturing Technologies Biomedical Engineering Researcher, Cardiovascular Engineering Laboratory, McGill University and Montreal Heart Institute, September 2002 March 2008, Montreal, Canada. Manufacturing Engineer and Production Supervisor, Cooper Industries, Bussmann Division, August 1999 August 2000, Chicago, Illinois. Supervised 60 team workers and floor supervisor to produce electric line items worth $23M USD in annual sales. Performed Lean Manufacturing, Kaizen, ERP Systems projects within the plant. Outsourced an entire production line to a plant in Cd. Juarez, México.

2 Manufacturing Engineering Consultant, Center for Integrated Manufacturing Systems, ITESM, September 1996 May Monterrey, México. EDUCATION Doctor of Philosophy Biomedical Engineering. McGill University, Montréal, Québec, Canada. Research field in computational modeling of atherosclerotic plaque rupture. Thesis A computational analysis to assess the coronary atherosclerotic plaque vulnerability to rupture due to hemodynamic effects. May Master of Engineering Mechanical Engineering. McGill University, Montréal, Québec, Canada. Thesis: Structural optimization of a coronary stent interacting with a hyperelastic arterial wall. June Bachelor of Science in Mechanical Engineering and Management. Instituto Tecnológico y de Estudios Superiores de Monterrey. México. May Minor in Artificial Intelligent Systems. Center for Artificial Intelligence. Instituto Tecnológico y de Estudios Superiores de Monterrey. México. May Certified Manufacturing Technologist. Society of Manufacturing Engineers. Dearborn, Michigan. September Certified Solidworks Associate (CSWA) Mechanical Design, Dassault Systemes Corporation, Certificate C-EM4FHHGYWW, March 2015 CONFERENCES Galaz R., Mongrain R., Ranga A., El-Khoury N., Tardif J.C., Structural analysis of a coronary stent interacting with an hyperelastic arterial wall, Endocoronary Biomechanics and Restenosis Symposium, Paris, France, Galaz R., Mongrain R., Ranga A., Brunette J., Bertrand O.F., Tardif J.C., FEA Structural Analysis of a Coronary Stent Interacting with an Hyperelastic Wall, Proceedings of the 1 International New Cardiovascular Congress, Québec City, Sept 10-11, Abstract P- 11, p 68, Galaz R., Mongrain R., Ranga A., Brunette J., Bertrand O.F., Tardif J.-C., FEA Structural Analysis of a Coronary Stent Interacting with a Hyperelastic Arterial Wall, Les Dixseptièmes Entretiens du Centre Jacques Cartier, Nano-biointerfaces pour les dispositifs intelligents,oct 7-8, Montréal, Galaz R., Pazos V., Mongrain, R., Leask R., Tardif, J.C., A numerical model of the rupture mechanics of the fibrous cap in atherosclerotic plaques, PACAM IX - Ninth Pan American Congress of Applied Mechanics, Mérida, Yucatán, México, January 2-6, Galaz R., Mongrain R., Pazos V., Leask R., Tardif J.C., Modelling of Hemodynamic Stress Effects on Rupture Mechanics and Fibrous Cap Collagen Architecture of Atherosclerotic

3 Plaques, Book of the Proceedings of The IASTED Conference on Modelling and Simulation, Montreal, 2006 Editor(s): R. Wamkeue 630 pages, ISBN: Galaz R., Mongrain R., Pazos V., Leask R., Tardif J.C., Modelling the stress condition dependant anisotropy and rupture mechanics of atherosclerotic plaques, Proceedings of the 2006 ASME Summer Bioengineering Conference, Amelia Island, Florida, Galaz R., Mongrain R., Pazos V., Leask R., Tardif J.C., Fluid-structure interaction computational modeling of realistically reconstructed atherosclerotic plaques to assess their vulnerability to rupture based on collagen fiber architecture # 6721, Proceedings of the 5th World Congress of Biomechanics, Munich, Germany, Galaz R., Mongrain R., Pazos V., Leask R., Tardif J.-C., Fluid-structure interaction computational modelling of realistically reconstructed atherosclerotic plaques to assess their vulnerability to rupture based on collagen fibre architecture, Journal of Biomechanics Vol. 39, 2006 Supplement 1 [abstract]. Galaz R., Mongrain R., Pazos V., Leask R., Tardif J.C., Transient Fluid Structure Interaction Computational Analyses to Assess Patient Specific Atherosclerotic Plaque Vulnerability, CompMed SSH Symposium on Computer Simulation in Medicine 2007, Montreal, Quebec, Canada, Galaz R., Mongrain R., Pazos V., Leask R., Tardif J.C., Computational sensitivity analyses to assess atherosclerotic plaque vulnerability, 21 st Canadian Congress on Applied Mechanics, Toronto, Ontario, Canada, Galaz R., Mongrain R., Pazos V., Leask R., Tardif J.C., Computational analysis to assess atherosclerotic plaque vulnerability due to hemodynamic effects, Proceedings of the 2007 ASME Summer Bioengineering Conference, Keystone, Colorado, Galaz R., Mongrain R., Leask R., Tardif J.C., Patient-specific coronary plaque vulnerability analyses based on 3D computer models of the mechanical interaction between hemodynamics and plaque constituents., Accepted abstract at the Canadian Cardiovascular Congress 2007, Quebec City, Canada, Galaz R., Mongrain R., Leask R., Tardif J.C., Computational fluid-structure interaction studies to assess the mechanical fatigue vulnerability of patient specific coronary plaques, Congres de la Recherche en Biomécanique Endocoronaire EBR2008, Marseille, France, April Galaz R., Olivas L., Mongrain R., Stent design optimization to minimize longitudinal deformation, Congrés de la Recherche en Biomécanique Endocardiovasculaire EBR 2012, Marseille, France, May Mongrain R., Galaz R., Ranga A., El-Khouri N., Bertrand O.F., Tardif J.C., Structural Analysis of a Coronary Stent Interacting with the Vascular Wall during Angioplasty. Archives of Physiology and Biochemistry, 111, Supp. p. 8, Mongrain R., Galaz R., Bertrand O., Deep wall injury due to atherosclerotic plaque reconfiguration during angioplasty and in-stent restenosis, 5 th World Congress of Biomechanics, Munich, Germany, 2006.

4 Mongrain R., Galaz R., Bulman-Fleming N., Ruzzeh B., Bertrand O.F., Tardif J.-C., Multidisciplinary Design Optimization of Stents, Proceedings of the ASME Summer Bioengineering Conference ISBN , Vail, Colorado, June 22-26, Mongrain R., Galaz R., Ranga A., El-Khoury N., Bertrand O.F., Tardif J.C., Structural analysis of a coronary stent interacting with the vascular wall during angioplasty, XXVIII Congres de la Societé de Biomecanique, Poitiers, France, Pazos V., Mongrain R., Galaz R., Leask R. Tardif J.C., Development of an atherosclerotic phantom with a lipid inclusion, Proceedings of the 5th World Congress of Biomechanics, Munich, Germany Mongrain R., Faik I., Ruzzeh B., Galaz R., Bertrand O., Optimization of drug-eluting stents using numerical simulations, Congres de la Recherche en Biomécanique Endocoronaire EBR2008, Marseille, France, April JOURNAL PUBLICATIONS Brunette J., Mongrain R., Laurier J., Galaz R., Tardif J.C., 3D flow study in a mildly stenotic coronary artery phantom using a whole volume PIV method, Journal of Medical Engineering & Physics, 30(9): , Ranga A., Mongrain R., Galaz R., Biadillah Y., Cartier R., Large displacement 3D structural analysis of an aortic valve model with nonlinear material properties. Journal of Medical Engineering & Technology, 28(3):95-103, Galaz, R., Pagiatakis, C., Gaillard, E. and Mongrain, R. (2013) A parameterized analysis of the mechanical stress for coronary plaque fibrous caps. Journal of Biomedical Science and Engineering, 6, doi: /jbise A006. Pagiatakis C, Galaz R, Tardif JC, Mongrain R. A comparison between the principal stress direction and collagen fiber orientation in coronary atherosclerotic plaque fibrous caps. Medical & Biological Engineering & Computing.June 2015, Volume 53, Issue 6, pp BOOK CHAPTERS Mongrain R., Leask R., Galaz R., Ranga A., Brunette J., J.C. Tardif, O.F. Bertrand, Image Based Biomechanics of Coronary Plaque, Plaque Imaging: Clinical analysis and its applications using MR, CT, Ultrasound and Microscopic., eds J. Suri, C. Yuan, D. Wilson, S. Laxminarayan, IOS Press, Amsterdam, Galaz R., Mongrain R., Pazos V., Leask R., Tardif J.-C., Fluid-structure interaction computational modelling of realistically reconstructed atherosclerotic plaques to assess their vulnerability to rupture based on collagen fibre architecture. Publisher: MEDIMOND, Bologna, Italy. (Book contribution of the Proceedings of the 5th World Congress of Biomechanics)

5 AWARDS Academic excellence teaching award, issued by Instituto Tecnológico y de Estudios Superiores de Monterrey, May 2010 Academic excellence teaching award, issued by Instituto Tecnológico y de Estudios Superiores de Monterrey, May 2012 Distinguished professor award, Biomedical Engineering class of 2015, issued by Instituto Tecnológico y de Estudios Superiores de Monterrey, Campus Monterrey, Dec 2015 GRANTS Fondo Mixto CONACYT Sonora State Government. Issued for TAUVEX S.A. de C.V. Grant proposal title Propuesta para el equipamiento de un laboratorio de diseño de nuevos productos en una empresa manufacturera de dispositivos medicos clase I y II, SON CO Total grant received $92,508 USD. January CONACYT INNOVAPYME 2010, Innovation stimulus program. Issued for TAUVEX S.A. de C.V. Grant proposal title Optimización topológica de tornillos ortopédicos para mejorar su biocompatibilidad. Total grant funds received $163,548 USD. June CONACYT INNOVAPYME 2011, Innovation stimulus program. Issued for TAUVEX S.A. de C.V. Grant proposal title Desarrollo de nuevos dispositivos médicos expandibles utilizados en varios procedimientos en anestesiología regional y obstétrica, cardiología, radiología y medicina del dolor. Total grant funds received $342,213 USD. June CONACYT PROINNOVA 2011, Innovation stimulus program. Issued for TAUVEX S.A. de C.V. Grant proposal title Diseño y desarrollo de un nuevo método e instrumentos de cirugía mínimamente invasiva para reconstrucción y reparación de tejidos. Total grant funds received $276,503 USD. December Fondo Mixto CONACYT Sonora State Government. Issued for TAUVEX S.A. de C.V. Grant proposal title Desarrollo de prototipos y pruebas clínicas de un nuevo dispositivo para la automuestreo de células epiteliales del cérvix para la detección del cáncer cervicouterino y VPH. Total grant funds received $60,000 USD. December CONACYT PROINNOVA 2014, Innovation stimulus program. Issued for GALAZ SCIENCE AND ENGINEERING S.A. de C.V. Grant proposal title Diseño y desarrollo de un sujetador de tubo endotraqueal pediátrico para aplicaciones de terapia intensiva. Total grant funds received $425,925 USD. March CONACYT PROINNOVA 2014, Innovation stimulus program. Issued for GALAZ SCIENCE AND ENGINEERING S.A. de C.V. Grant proposal title Diseño de un implante coronario bifurcado para la prevención del infarto agudo al miocardio. Total grant funds received $522,000 USD. March CONACYT PROINNOVA 2016, Innovation stimulus program. Issued for GALAZ SCIENCE AND ENGINEERING S.A. de C.V. Grant proposal title Diseño, Optimización y Desarrollo de un Implante Endovascular Coronario para la Prevención del Infarto Agudo al Miocardio. Total grant funds received $265,000 USD. March CONACYT INNOVAPYME 2016, Innovation stimulus program. Issued for ZIPTEK MEXICO S.A. de C.V. Grant proposal title Diseño y Desarrollo de un Nuevo Método y Dispositivos

6 para Cirugía Ortopédica con Polímeros Bioabsorbibles. Total grant funds received $200,000 USD. March PATENTS DISPOSITIVO INTRAVAGINAL DE DISEÑO ANATÓMICO Y COLAPSABLE PARA EL AUTOMUESTREO DE CÉLULAS EPITELIALES DEL CÉRVIX. Submitted to the Instituto Mexicano de la Propiedad Industrial. August Registro MX/2009/057823, Expediente de Patente MX/a/2009/ ANATOMICALLY DESIGNED AND COLLAPSIBLE INTRAVAGINAL DEVICE FOR SELF-SAMPLING AND CONTAINMENT OF CERVICAL EPITHELIAL CELLS. Application # PCT/IB2010/ World Intellectual Property Organization (WIPO). August 20, ANATOMICALLY DESIGNED AND COLLAPSIBLE INTRAVAGINAL DEVICE FOR SELF-SAMPLING AND CONTAINMENT OF CERVICAL EPITHELIAL CELLS. Application # US2012/ A1. United States Patent Office. June 21, SURGICAL SUTURE SYSTEM, TISSUE RESTRAINT/SUTURE CAPTURE AND TISSUE ANCHOR. UNITED STATES PATENT AND TRADEMARK OFFICE Patent No. 9,307,979 B1. Issue date: Apr. 12, 2016 SISTEMAS DE SUTURA QUIRÚRGICA, RESTRICCIÓN DE TEJIDO/CAPTURA DE SUTURA Y ANCLAJE DE TEJIDO. Instituto Mexicano de la Propiedad Industrial MX/a/2015/004243, PCT/US2013/ ANATOMICALLY DESIGNED AND COLLAPSIBLE INTRAVAGINAL DEVICE FOR SELF-SAMPLING AND CONTAINMENT OF CERVICAL EPITHELIAL CELLS. US A1. United States Patent Office. June DISPOSITIVO DE ACCESO INTRAVENOSO EXPANDIBLE. Instituto Mexicano de la Propiedad Industrial MX/a/2012/ ENDOPRÓTESIS VASCULAR PARA TRATAR LESIONS BIFURCADAS EN ARTERIAS CORONARIAS. Instituto Mexicano de la Propiedad Industrial MX/2015/ TORNILLO TRANSPEDICULAR PARA LA ALINEACIÓN DE LA COLUMNA. Instituto Mexicano de la Propiedad Industrial MX/2015/ SUJETADOR DE TUBO ENDOTRAQUEAL PARA PACIENTES PEDIÁTRICOS Instituto Mexicano de la Propiedad Industrial MX/2015/003489, PCT Application PCT/MX/2015/ DISPOSITIVO PARA AUTOTOMA DE MUESTRAS DE CÉLULAS EPITELIALES PARA LA DETECCIÓN DE CÁNCER CERVICOUTERINO. Instituto Mexicano de la Propiedad Industrial MX/2015/003513, PCT Application PCT/MX/2015/000013

7 INVITED LECTURES Biomecánica, Congreso Internacional de Ingeniería Mecánica, ITESM, Monterrey, México. October Onceavo Día del Ingeniero Mecánico, Biomecánica, ITESM, Monterrey, México. April Optimización del diseño de prótesis endovasculares, III Congreso Internacional de Ingeniería Biomédica, ITESM, Monterrey, Mexico. April Interacción Fluido Estructura y Biomecánica de Tejidos, III Congreso Internacional de Ingeniería Biomédica, ITESM, Monterrey, Mexico, April Diseño de implantes cardiovasculares, VI Simposium de Ingeniería Biomédica, ITESM, Monterrey, Mexico, March Aplicación de análisis de elemento finito al diseño de dispositivos médicos. VII Congreso Internacional de Ingeniería Biomédica, ITESM, Monterrey, Mexico, March Marco regulatorio del mercado de dispositivos médicos COFEPRIS / FDA. Expo- Manufactura 2012, Cintermex, Monterrey, N.L. Mexico, March 2012 Guest speaker at convocation ceremony for graduating class of December ITESM Campus Sonora Norte. Hermosillo, Sonora, Mexico, December Impactos de la vinculación empresa-academia en el marco del programa de estímulos a la innovación. Consejo Estatal de Ciencia y Tecnología, Hermosillo, Sonora, October Diseño de implantes ortopédicos, IX Simposium de Ingeniería Biomédica, ITESM, Monterrey, Mexico, April 2013 La ingeniería mecánica en el diseño de dispositivos médicos, XXVI Congreso de Ingeniería Mecánica, ITESM, Monterrey, Mexico, November 2013 Quality systems for medical device manufacturing. 2 nd International Conference on Design and Processes for Medical Devices, Monterrey, Mexico March 2014 La Ingeniería Biomédica aplicada en el desarrollo de dispositivos médicos. Congreso de Ingenierías. Universidad La Salle, Cd. Obregón, México, April 2016 AFFILIATIONS President of the Mexican Chapter of the Society of Manufacturing Engineers (SME) Member of the American Society of Mechanical Engineers since Member of the 2011 editorial board of the newspaper EL IMPARCIAL.

8 Member of the Technical Evaluating Committee of CONACYT FOMIX Sonora State Government July 2011 present. External Advisor (Ad-honorem) for the National Institute of Cardiology of Mexico in biomedical engineering technology and medical devices. March 2016-present. Member of the Accredited Evaluators Registry of Conacyt (Registro Conacyt de Evaluadores Acreditados RCEA). September present. RCEA Reviewer at the Journal of Medical Devices (Published by the American Society of Mechanical Engineers - ASME). ISSN

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