Sugita Titanium 2 from Mizuho. Revolutionizing aneurysm management, again.

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1 S U G I TA T I TA N I U M A N E U RY S M C L I P S A N D A P P L I E R S TM

2 Sugita Titanium 2 from Mizuho. Revolutionizing aneurysm management, again. Tomorrow s aneurysm management is available today embodied in the new Sugita Titanium 2 Clip. T2 isn t an old design recast in new material but rather a truly innovative advancement, patiently evolved from the industry s most trusted and acclaimed design. By integrating a new, ultra-slim spring-profile that s 50% thinner, with today s widest blade opening and an exclusive bridge-wire system, Mizuho has given you today what you ve waited years for unprecedented handling and control and a clearer line of sight. T2 the future has just arrived. Sugita Titanium 2 Clip Sugita Titanium 2 Clip Sugita Clip Ultra-Slim Spring Using cutting-edge technology available exclusively to Mizuho, designers reduced the already ultra-low Sugita spring profile by 50%, giving surgeons unprecedented ease of handling and greater visibility of local anatomy. Sugita Clip Delicately Tapered Blade A slim blade design with tapered tip allows a smooth approach into deeper, hard-to-reach surgical sites. The finer blade and distal tip contributes to exposure of vital surrounding structures. Widest Opening Available The industry s widest blade opening provides greater freedom of movement when maneuvering the clip over the aneurysm neck, while the exclusive Sugita bridgewire system prevents twisting. 2

3 Atraumatic Blade Impact The channel-shaped pattern uniformly covers the blade s surface, effectively widening the contact area and improving grip force for a strong, consistent hold. Unique design helps ensure vessel safety by reducing slippage and preserving tissue integrity. MRI Compatibility T2 s Titanium alloy offers excellent biological compatibility, durability and wear resistance for permanent implantation. Independent, third-party tests, using FDA and ASTM standards, prove T2 Clips to be MR-safe to 4 Tesla. A Clip for Every Need To facilitate treatment of complex aneurysms, the T2 Clip is available in a wide variety of blade shapes, lengths and angles. Clip-spring colors match appropriate appliers for fast, accurate instrument identification. 3

4 Quality you expect. Safety you can trust. Every Sugita aneurysm clip, including the new T2, embodies Mizuho s never-ending commitment to product quality and patient safety. From development and manufacturing through inspection and logistics, clips undergo stringent monitoring and control to assure optimal reliability and performance. Individual Lot Numbers Lot numbers, laser etched on each clip, permit long-term traceability throughout the treatment period, and enable detailed clip data to be easily obtained, should the need arise. Closing Force Labeling Every clip label lists individual specifications plus clip closing force. Sugita is the first clip brand to indicate closing force on individual packages. NOTE: All clips are packaged and delivered non-sterile. Please sterilize before using. Blade Holding Force Type Holding force Temporary Fenestrated Mini Mini Temporary Innovative product configurations Clip springs and jaw colors are color coordinated to help accurately match clips with their corresponding appliers/removers. Clip type Applier/Remover type Series Temporary Fenestrated Mini Series Mini Mini Mini Temporary 4

5 Implant: Series Closing Force In accordance with ISO09713, closing force is measured by opening the clip 1.0 mm. A computerized gauge meter measures force 1/3 blade length from the distal tip. Results are indicated on the clip label in both Newtons and grams No No No. 3 Bayonet No No. 5 Sideward No. 6 Sideward No. 7 Sideward Bayonet No No. 9 Slightly No No. 11 Sideward No No. 13 Bayonet No. 14 Bayonet No No. 16 Slightly Bayonet No. 17 Slightly No No No No No. 23 J-Shaped No. 24 J-Shaped No. 25 J-Shaped No Angle No Angle No Angle 5

6 Implant: and Temporary Series Temporary No No. 60 w/curve No. 61 w/curve No. 62 1/ No. 63 1/ No. 64 (4B) Slightly No. 65 Slightly No No. 68 (8B) Slightly No No. 73 1/ No No No. 53 Bayonet No No. 55 Slightly 6

7 Implant: Fenestrated Series Fenestrated Fenestrated No No No No No No No No No No No No No No No No No No. 43 7

8 Implant: Mini and Mini Temporary Series Mini Mini No No No No No. 95 Slim Tip No. 96 Slim Tip No. 97 Slim Tip No. 98 Slim Tip No Sideward No Bayonet No Slim Tip Mini Temporary No No. 86 Sideward No No No. 89 Bayonet 8 Mini No. 99 Slim Tip No No No Slightly No Slightly No No No. 58 Slim Tip

9 Redesigned clip-case simplifies set selection. Mizuho s modular clip-case system is laser-etched with detailed clip drawings that make it easy to organize, select, sterilize and stock a full surgical set. The system conveniently stores multiple clips per compartment and up to fourteen different appliers. Four Individually Modular Clip Cases The new T2 Clip sterilization case houses an entire set of aneurysm clips and appliers, with the room to store up to 120 individual clips and 14 different appliers, which fit securely into the all-encompassing lid with soft silicone brackets. Detailed Drawings for Easy Instrument ID To facilitate selection of the appropriate pattern, individual cases are laser etched with a two-sided clip drawing. Corresponding catalog numbers are also etched inside each cavity for ease of restocking. Convenient Quick-Access Design Clip cases are organized by clip type, allowing for quick access to the desired pattern: /Large Clips Temporary/Mini/ Clips Fenestrated Clips Deflected Fenestrated/Long Clips 9

10 Low-profile appliers and removers to suit every surgical need. Like our T2 Clips, Mizuho appliers and removers feature a slim, low-profile design for optimal visibility during placement or removal. Sugita Titanium 2 Clip Applier Sugita Titanium 2 Clip Applier Mini Diverse Instrument Selection Mizuho offers a full variety of appliers to complement T2 Clips. There are Short (70 mm), (90 mm), and Long (110 mm) lengths available, as well as straight and angled shapes. The slim, ultra-light, perfectly balanced appliers feature meticulously milled jaw grooves to facilitate a sure, no-slip grip and vibration-free release. Uniquely Color Coded for Safety, Ease of Use T2 Clips are fully compatible with Mizuho s familiar line of and Mini Appliers. By color coordinating the applier s jaw with the color of the clip spring, the correct applier/clip combination can be verified at a glance, ensuring proper instrument selection during surgery. (Front view) Removers Clip + Applier Temporary Clip + Applier Fenestrated Clip + Applier Mini Clip + Mini Applier Mini Temporary Clip + Mini Applier (Front view) 30 (Side view) 15 (Side view) (Side view) Laterally angled (Front view) 10

11 Ordering information. Aneurysm Clip Cases Product Code Product Name Sugita Titanium 2 Clip Sterilization Case (Full set) S Sugita Titanium 2 Clip Sterilization Case (/Large clips) T Sugita Titanium 2 Clip Sterilization Case (Mini/Temporary/ clips) F Sugita Titanium 2 Clip Sterilization Case (Fenestrated/Large clips) D Sugita Titanium 2 Clip Sterilization Case (Defected Fenestrated/Long clips) Clips Product Code Description T mm T mm T Bayonet 7mm T mm T Sideward 8mm T Sideward 9mm T Sideward Bayonet 8.5mm T mm T Slightly 9mm T mm T Sideward 12mm T mm T Bayonet 10mm T Bayonet 12mm T mm T Slightly Bayonet 12mm T Slightly 18mm T mm T mm T mm T mm T2 9.0 J-Shaped 6mm T2 9.0 J-Shaped 7.5 mm T2 9.5 J-Shaped 9.0mm T Angle 5mm T Angle 7.5mm T Angle 10mm T mm T2 8.0 L-Shape w/curve 7.5mm T2 8.0 w/curve 10mm T /4 7.5mm T /4 8.6mm T Slightly 8mm T Slightly 11mm T mm T Slightly 9mm T mm T /4 11mm Temporary Clips Product Code Description T2 Temp mm T2 Temp mm T2 Temp Bayonet 7mm T2 Temp mm T2 Temp Slightly 11mm Fenestrated Clips Product Code Description T Fen.3.5 6mm T Fen mm T Fen mm T Fen mm T Fen mm T Fen mm T2 8.5 Fen mm T2 9.0 Fen mm T Fen mm T2 9.5 Fen mm T Fen mm T Fen mm T2 7.5 Fen mm T2 7.5 Fen mm T2 7.5 Fen mm T2 8.5 Fen mm T2 8.5 Fen mm T2 8.5 Fen mm Mini Clips Product Code Description T2 Mini 5.5 4mm T2 Mini 7.0 6mm T2 Mini 6.5 5mm T2 Mini 7.0 5mm T2 Mini 5.5 4mm T2 Mini 7.5 Sideward 7mm T2 Mini 6.0 5mm T2 Mini 7.5 7mm T2 Mini 8.5 Bayonet 5mm T2 Mini 5.5 Slim Tip 4mm T2 Mini 7.0 Slim Tip 6mm T2 Mini 7.0 Slim Tip 6.7mm T2 Mini 8.0 Slim Tip 8.2mm T2 Mini 6.5 Slim Tip 5.2mm T2 Mini 8.0 8mm T2 Mini mm T2 Mini 6.5 Slightly 5.5mm T2 Mini 7.0 Slightly 6.5mm T2 Mini 8.5 Sideward 6mm T2 Mini 10.0 Bayonet 7mm T2 Mini 6.5 Slim Tip 5.5mm Mini Temporary Clips Product Code Description T2 Mini Temp mm T2 Mini Temp mm T2 Mini Temp. 7.0 Slim Tip 6mm Sugita Titanium 2 Aneurysm Clip Appliers and Removers Product Code Description mm º Angled 90mm º Angled 90mm Remover 90mm Mini 90mm Mini 15º Angled 90mm Mini 30º Angled 90mm Mini Remover 90mm mm mm Remover 30º Angled 90mm Laterally Angled 110mm Mini 70mm Mini 110mm Mini Remover 30º Angled 90mm Mini Laterally Angled 110mm 11

12 Mizuho America, Inc CLIP (2547) mizuho.com 133 Brimbal Avenue Beverly, MA T2 01 Rev. 2 7/07 Head Strong TM

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